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Cited by 271Regulation of Appetite and ObesitySleep and Wakefulness ResearchNeurotransmitter Receptor Influence on Behavior

Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour

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Bonnavion, Patricia, Mickelsen, Laura E., Fujita, Akie, de Lecea, Luis, Jackson, Alexander C.·2016·The Journal of Physiology
DOI 10.1113/jp271946PMC PMC5108896
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Abstract

The hypothalamus is among the most phylogenetically conserved regions in the vertebrate brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By integrating signals arising from both the brain and periphery, it governs a litany of behaviourally important functions essential for survival. In particular, the lateral hypothalamic area (LHA) is central to the orchestration of sleep–wake states, feeding, energy balance and motivated behaviour. Underlying these diverse functions is a heterogeneous assembly of cell populations typically defined by neurochemical markers, such as the well‐described neuropeptides hypocretin/orexin and melanin‐concentrating hormone. However, anatomical and functional evidence suggests a rich diversity of other cell populations with complex neurochemical profiles that include neuropeptides, receptors and components of fast neurotransmission. Collectively, the LHA acts as a hub for the integration of diverse central and peripheral signals and, through complex local and long‐range output circuits, coordinates adaptive behavioural responses to the environment. Despite tremendous progress in our understanding of the LHA, defining the identity of functionally discrete LHA cell types, and their roles in driving complex behaviour, remain significant challenges in the field. In this review, we discuss advances in our understanding of the neurochemical and cellular heterogeneity of LHA neurons and the recent application of powerful new techniques, such as opto‐ and chemogenetics, in defining the role of LHA circuits in feeding, reward, arousal and stress. From pioneering work to recent developments, we review how the interrogation of LHA cells and circuits is contributing to a mechanistic understanding of how the LHA coordinates complex behaviour. image

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Cited by

Sorted by citations

Authors
Bonnavion, P., Mickelsen, L. E., Fujita, A., de Lecea, L., & Jackson, A. C.
Affiliations
  • Université Libre de Bruxelles (BE)
  • University of Connecticut (US)
  • Department of Psychiatry and Behavioural Sciences Stanford University School of Medicine Stanford CA 94305 USA
Corresponding author
Jackson, Alexander C.
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
2016-07-19
Volume
594
Issue
22
Pages
6443-6462
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jp271946
PMC
PMC5108896
OpenAlex
W2435054000
Cited by
271
References
12
Citations by year
2026: 32 · 2025: 28 · 2024: 29 · 2023: 37 · 2022: 23 · 2021: 35 · 2020: 28 · 2019: 17 · 2018: 21 · 2017: 19 · 2016: 2
FWCI
2.05
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Funders
  • International Brain Research Organization
  • National Alliance for Research on Schizophrenia and Depression
  • Hilda and Preston Davis Foundation
  • National Institute of Mental Health (R01MH087592061, R00MH097792)
  • National Institute on Aging (R01AG04767102)
  • Klarman Family Foundation
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
lateral hypothalamus, hypothalamic neurons, neuronal cell types, hypocretin/orexin, melanin-concentrating hormone, neuropeptides, sleep-wake regulation, feeding behaviour, energy balance, motivated behavior, reward, arousal, stress, neural circuits, optogenetics, chemogenetics
MeSH terms
Animals, Brain, Humans, Hypothalamic Area, Lateral, Hypothalamic Hormones, Melanins, Neurons, Neuropeptides, Pituitary Hormones

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