Cited by 191Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

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Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease

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Troncoso-Escudero, Paulina, Parra, Alejandra, Nassif, Melissa, Vidal, Rene L.·2018·Frontiers in Neurology

DOI 10.3389/fneur.2018.00860PMC PMC6232883

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Abstract

Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-derived immune cells. Furthermore, the evidence of the contribution of systemic delivered molecules to the disease pathogenesis, such as the gut microbiota composition, has been increasing during the last years. Under physiological conditions, microglia and astrocytes support the well-being and well-function of the brain through diverse functions, including neurotrophic factor secretion in both intact and injured brain. On the other hand, genes that cause PD are expressed in astrocytes and microglia, shifting their neuroprotective role to a pathogenic one, contributing to disease onset and progression. In addition, growth factors are a subset of molecules that promote cellular survival, differentiation and maturation, which are critical signaling factors promoting the communication between cells, including neurons and blood-derived immune cells. We summarize the potential targeting of astrocytes and microglia and the systemic contribution of the gut microbiota in neuroinflammation process archived in PD.

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Authors: Troncoso-Escudero, P., Parra, A., Nassif, M., & Vidal, R. L.
Affiliations: Universidad Mayor (CL)
ORCID: Troncoso-Escudero, Paulina
Nassif, Melissa
Venue: Frontiers in Neurology
Publisher: Frontiers Media SA
Published: 2018-10-15
Volume: 9
Pages: 860-860
ISSN: 1664-2295 (ISSN-L)
DOI: 10.3389/fneur.2018.00860
PMC: PMC6232883
OpenAlex: W2895971387
Cited by: 191
References: 193
Citations by year: 2026: 12 · 2025: 27 · 2024: 22 · 2023: 38 · 2022: 35 · 2021: 19 · 2020: 32 · 2019: 6
FWCI: 1.35
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Neurology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Universidad de Chile (submittedVersion, cc-by-nc-nd)
Funders: Fondo Nacional de Desarrollo Científico y Tecnológico (1150608, 11160288)
Comisión Nacional de Investigación Científica y Tecnológica (21160843, 21181114)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: Parkinson's disease, neuroinflammation, microglia, astrocytes, gut microbiota, systemic inflammation, disease progression, neuroprotective factors, growth factors, neurotrophic factors, immune cells, therapeutic targeting

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