Cited by 150Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorHypothalamic control of reproductive hormones

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Serotonin and the regulation of mammalian energy balance

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Donovan, Michael H., Tecott, Laurence H.·2013·Frontiers in Neuroscience

DOI 10.3389/fnins.2013.00036PMC PMC3608917

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Abstract

Maintenance of energy balance requires regulation of the amount and timing of food intake. Decades of experiments utilizing pharmacological and later genetic manipulations have demonstrated the importance of serotonin signaling in this regulation. Much progress has been made in recent years in understanding how central nervous system (CNS) serotonin systems acting through a diverse array of serotonin receptors impact feeding behavior and metabolism. Particular attention has been paid to mechanisms through which serotonin impacts energy balance pathways within the hypothalamus. How upstream factors relevant to energy balance regulate the release of hypothalamic serotonin is less clear, but work addressing this issue is underway. Generally, investigation into the central serotonergic regulation of energy balance has had a predominantly "hypothalamocentric" focus, yet non-hypothalamic structures that have been implicated in energy balance regulation also receive serotonergic innervation and express multiple subtypes of serotonin receptors. Moreover, there is a growing appreciation of the diverse mechanisms through which peripheral serotonin impacts energy balance regulation. Clearly, the serotonergic regulation of energy balance is a field characterized by both rapid advances and by an extensive and diverse set of central and peripheral mechanisms yet to be delineated.

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Authors: Donovan, M. H., & Tecott, L. H.
Affiliations: University of California, San Francisco (US)
Corresponding author: Tecott, Laurence H.
ORCID: Donovan, Michael H.
Venue: Frontiers in Neuroscience
Publisher: Frontiers Media SA
Published: 2013
Volume: 7
Pages: 36-36
ISSN: 1662-453X (ISSN-L)
DOI: 10.3389/fnins.2013.00036
PMC: PMC3608917
OpenAlex: W2112809623
Cited by: 150
References: 248
Citations by year: 2026: 6 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 22 · 2020: 16 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 12 · 2015: 11 · 2014: 6 · 2013: 3
FWCI: 5.76
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: serotonin, energy balance, feeding behavior, serotonin receptors, hypothalamus, central serotonergic system, peripheral serotonin, food intake regulation, metabolism

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Serotonin and the regulation of mammalian energy balance

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