Cited by 292Stress Responses and CortisolRedox biology and oxidative stressAdrenal Hormones and Disorders

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Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

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Spiers, Jereme G., Chen, Hsiao-Jou Cortina, Sernia, Conrad, Lavidis, Nickolas A.·2015·Frontiers in Neuroscience

DOI 10.3389/fnins.2014.00456PMC PMC4298223

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Abstract

Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.

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Authors: Spiers, J. G., Chen, H.-J. C., Sernia, C., & Lavidis, N. A.
Affiliations: The University of Queensland (AU)
Corresponding author: Spiers, Jereme G.
ORCID: Spiers, Jereme G.
Chen, Hsiao-Jou Cortina
Sernia, Conrad
Venue: Frontiers in Neuroscience
Publisher: Frontiers Media SA
Published: 2015-01-19
Volume: 8
Pages: 456-456
ISSN: 1662-453X (ISSN-L)
DOI: 10.3389/fnins.2014.00456
PMC: PMC4298223
OpenAlex: W1984410984
Cited by: 292
References: 73
Citations by year: 2026: 24 · 2025: 39 · 2024: 23 · 2023: 33 · 2022: 30 · 2021: 39 · 2020: 29 · 2019: 21 · 2018: 17 · 2017: 20 · 2016: 11 · 2015: 6
FWCI: 1.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: hypothalamic-pituitary-adrenal axis, glucocorticoids, oxidative stress, redox systems, hippocampus, stress, adrenal cortex, neuroendocrinology

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Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

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