The DOI matches its Crossref record; 247 of the 247 references it cites were found in a registry or an index.
Immune aging, dysmetabolism, and inflammation in neurological diseases
Open accessAbstract
As we age, the immune system undergoes a process of senescence accompanied by the increased production of proinflammatory cytokines, a chronic subclinical condition named as "inflammaging". Emerging evidence from human and experimental models suggest that immune senescence also affects the central nervous system and promotes neuronal dysfunction, especially within susceptible neuronal populations. In this review we discuss the potential role of immune aging, inflammation and metabolic derangement in neurological diseases. The discovery of novel therapeutic strategies targeting age-linked inflammation may promote healthy brain aging and the treatment of neurodegenerative as well as neuropsychiatric disorders.
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“At the systemic level, peripheral inflammaging leads to low-level production of inflammatory mediators in the circulation, including IL-6, TNF-α, and C-reactive protein (CRP), which also contribute to the inflammatory environment in the CNS.36,49,116”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [116]
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Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668
“BCSFB disruption impaired the selectivity of it, leading to increased infiltration of cytokines and leukocytes into the CSF which then activated glial cells in the CNS.144,145 BCSFB acts as a gateway for inflammationresolving leukocyte entry into the CSF during immune responses through the constitutively expressed adh…”
BackgroundInfluentialMrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.011 · Cited by 1,010
Protein misfolding in neurodegenerative diseases: Implications and strategies
Sweeney, P., Park, H., Baumann, M., Dunlop, J., Frydman, J., Kopito, R., McCampbell, A., Leblanc, G., Venkateswaran, A., Nurmi, A., et al. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0077-5 · Cited by 675
The aging clock: circadian rhythms and later life
Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 641
Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease
Newcombe, E. A., Camats-Perna, J., Silva, M. L., Valmas, N., Huat, T. J., & Medeiros, R. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1313-3 · Cited by 532
Metadata
- Authors
- Deleidi, M., Jäggle, M., & Rubino, G.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- University of Tübingen (DE)
- Corresponding author
- Deleidi, Michela
- ORCID
- Deleidi, Michela
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-06-03
- Volume
- 9
- Pages
- 172-172
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC4453474
- OpenAlex
- W1486303545
- Cited by
- 260
- References
- 247
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 18 · 2023: 27 · 2022: 37 · 2021: 23 · 2020: 26 · 2019: 26 · 2018: 28 · 2017: 26 · 2016: 17 · 2015: 5
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DZNE Pub (submittedVersion, other-oa)
- Funders
- European Commission (304108)
- Fritz Thyssen Stiftung
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- immunosenescence, inflammaging, neuroinflammation, neurodegenerative diseases, neuropsychiatric disorders, inflammatory cytokines, brain aging, neuronal dysfunction, anti-inflammatory therapy
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