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The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

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Human NK cells display major phenotypic and functional changes over the life span

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Physiological Functions of APP Family ProteinsPreprint

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Immunosenescence and cancer

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Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

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NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies

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T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers

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A Reassessment of IgM Memory Subsets in Humans

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Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease

Chavda, V. K., Singh, K., Patel, V., Mishra, M., & Mishra, A. K. (2022) · Brain Sciences · doi:10.3390/brainsci12010075 · Cited by 29 · see citing works

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29 · see citing works

Accelerated hematopoietic mitotic aging measured by DNA methylation, blood cell lineage, and Parkinson’s disease

Paul, K., Binder, A. M., Horvath, S., Kusters, C. D. J., Yan, Q., Rosario, I. D., Yu, Y., Bronstein, J., & Ritz, B. (2021) · BMC Genomics · doi:10.1186/s12864-021-08009-y · Cited by 25 · see citing works

Reliable Hallmarks and Biomarkers of Senescent Lymphocytes

Сергеевна, М. Ю., Tereshchenko, V., Bogdanova, D. A., & Александрович, Р. С. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115653 · Cited by 28 · see citing works

Impact of probiotics and prebiotics in the modulation of the major events of the aging process: A systematic review of randomized controlled trials

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Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation

Ribeiro, C. T., Gasparotto, J., Petiz, L. L., Brum, P. O., Peixoto, D. O., Kunzler, A., da Rosa, H. T., Bortolin, R. C., Almeida, R. F., Quintans‐Júnior, L. J., et al. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.02.021 · Cited by 24 · see citing works

A Perspective on Roles Played by Immunosenescence in the Pathobiology of Alzheimer's Disease

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Challenges of infectious diseases in older adults: From immunosenescence and inflammaging through antibiotic resistance to management strategies

Mancinetti, F., Marinelli, A., Boccardi, V., & Mecocci, P. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111998 · Cited by 24 · see citing works

A comparison of hippocampal microglial responses in aged and young rodents following dependent and non-dependent binge drinking

Grifasi, I. R., Evans, W. A., Rexha, A. D., Sako, L. W., & Marshall, S. A. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.10.018 · Cited by 21 · see citing works

T and B cell subsets differentially correlate with amyloid deposition and neurocognitive function in patients with amnestic mild cognitive impairment after one year of physical activity

Poinsatte, K., Monson, N. L., Zhang, R., Stowe, A. M., Huebinger, R. M., Cullum, C. M., Monson, N. L., Zhang, R., & Stowe, A. M. (2026) · PubMed · doi:10.22029/eir.2019.1727 · Cited by 20 · see citing works

Peripheral sTREM2-Related Inflammatory Activity Alterations in Early-Stage Alzheimer’s Disease

Weber, G. E., Khrestian, M., Tuason, E. D., Shao, Y. Y., Pillai, J. A., Rao, S. M., Feng, H., Zhou, Y., Cheng, F., DeSilva, T. M., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100771 · Cited by 20 · see citing works

From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction

Luca, F. D., Camporeale, V., Leccese, G., Cuttano, R., Troise, D. E., Infante, B., Stallone, G., Netti, G. S., & Ranieri, E. (2025) · Cells · doi:10.3390/cells14221831 · Cited by 21 · see citing works

Impact of NLRP3 Depletion on Aging-Related Metaflammation, Cognitive Function, and Social Behavior in Mice

Хилажева, Е. Д., Mosiagina, A. I., Panina, Y. A., Belozor, О. S., & Komleva, Y. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316580 · Cited by 19 · see citing works

A possible effect of montelukast on neurological aging examined by the use of register data

Grinde, B., Schirmer, H., Eggen, A. E., Aigner, L., & Engdahl, B. (2020) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-020-01160-8 · Cited by 19 · see citing works

Allo-priming as a universal anti-viral vaccine: protecting elderly from current COVID-19 and any future unknown viral outbreak

Har-Noy, M., & Or, R. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02363-3 · Cited by 20 · see citing works

Effects of exercise on neuroinflammation in age-related neurodegenerative disorders

Su, Y., & Su, Z. (2025) · European journal of medical research · doi:10.1186/s40001-025-03165-3 · Cited by 18 · see citing works

Immunity orchestrates a bridge in gut-brain axis of neurodegenerative diseases

Cheng, Y., Chen, C., & Zhang, F. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101857 · Cited by 17 · see citing works

Peripherally-sourced myeloid antigen presenting cells increase with advanced aging

Honarpisheh, P., Blixt, F. W., Conesa, M. P. B., Won, W. W., d’Aigle, J., Munshi, Y., Hudobenko, J., Furr, J. W., Mobley, A. S., Lee, J., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.08.023 · Cited by 17 · see citing works

Normal aging, motor neurone disease, and Alzheimer’s disease are characterized by cortical changes in inflammatory cytokines

Tennakoon, A., Katharesan, V., Musgrave, I., Koblar, S. A., Faull, R. L. M., Curtis, M. A., & Johnson, I. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24996 · Cited by 17 · see citing works

A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project

Pirazzini, C., Azevedo, T., Baldelli, L., Bartoletti‐Stella, A., Buonaura, G. C., Molin, A. D., Dimitri, G. M., Doykov, I., Gómez‐Garre, P., Hägg, S., et al. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111426 · Cited by 15 · see citing works

Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders

Palumbo, M. L., Moroni, A. D., Quiroga, S., Castro, M. M., Burgueño, A. L., & Genaro, A. M. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.795 · Cited by 12 · see citing works

Immune cell counts in cerebrospinal fluid predict cognitive function in aging and neurodegenerative disease

Snyder, A., Grant, H. E., Chou, A., Lindbergh, C. A., Kramer, J. H., Miller, B. L., & Elahi, F. M. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12956 · Cited by 13 · see citing works

Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction

Jallah, B. P., & Kuypers, D. R. J. (2024) · Drugs & Aging · doi:10.1007/s40266-024-01100-5 · Cited by 12 · see citing works

Viruses and the Brain—A Relationship Prone to Trouble

Mielcarska, M. B., & Rouse, B. T. (2025) · Viruses · doi:10.3390/v17020203 · Cited by 12 · see citing works

In silico, in vitro and in vivo studies indicate resveratrol analogue as a potential alternative for neuroinflammatory disorders

de Assis, P. M., Fávero, A., Menegasso, J. F., Meinel, R. S., Marion, G. M., Nunes, V. S., Goliatt, P. V. Z. C., da Silva, A. D., Dutra, R. C., & Raposo, N. R. B. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117538 · Cited by 12 · see citing works

Role of Autophagy in HIV-1 and Drug Abuse-Mediated Neuroinflammaging

Sil, S., Thangaraj, A., Oladapo, A., Hu, G., Kutchy, N. A., Liao, K., Buch, S. J., & Periyasamy, P. (2022) · Viruses · doi:10.3390/v15010044 · Cited by 10 · see citing works

Acetylsalicylic acid improves cognitive performance in sleep deprived adult Zebrafish (Danio rerio) model

Bishir, M., Aslam, M., Bhat, A., Ray, B., Elumalai, P., Jyothi Priya, R., Rashan, L. J., Yang, J. P., Chang, S. L., Essa, M. M., et al. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4928 · Cited by 10 · see citing works

Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice

Ma, X., Prokopenko, D., Wang, N., Aikawa, T., Choi, Y., Zhang, C. M., Lei, D., Ren, Y., Kawatani, K., Starling, S. C., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106813 · Cited by 9 · see citing works

Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence

Dema, M. G., Eixarch, H., Hervera, A., Castillo, M., Villar, L. M., Montalbán, X., & Espejo, C. (2025) · Aging Cell · doi:10.1111/acel.14491 · Cited by 9 · see citing works

Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications

Bertoni, G., Ristori, S., & Monti, D. (2026) · Cells · doi:10.3390/cells15080657 · Cited by 9 · see citing works

An evaluation of the recognised systemic inflammatory biomarkers of chronic sub-optimal inflammation provides evidence for inflammageing (IFA) during multiple sclerosis (MS)

Bolton, C. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00225-0 · Cited by 10 · see citing works

Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases

Chen, Y. J., Liao, Y., Tram, V. T. N., Lin, C. H., Liao, K., & Liu, C.-L. (2020) · Life · doi:10.3390/life10100246 · Cited by 9 · see citing works

Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration

Stürzbecher, L., Bartolomaeus, H., Bartolomaeus, T. U. P., Bolz, S., Sekulic, A., Ueffing, M., Clark, S. J., Reichhart, N., Crespo‐Garcia, S., Wilck, N., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1520188 · Cited by 8 · see citing works

CAR Treg therapies for neurodegenerative diseases

Stein, D. N., & Gendelman, H. E. (2026) · iScience · doi:10.1016/j.isci.2026.114988 · Cited by 8 · see citing works

Translational bioinformatics and data science for biomarker discovery in mental health: an analytical review

Bhuvaneshwar, K., & Gusev, Y. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae098 · Cited by 8 · see citing works

Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)

Bolton, C. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00473-w · Cited by 7 · see citing works

Mecanismos moleculares do envelhecimento: revisão da literatura

d’Avila, J. C., Ramos, A. C. B., Dourado, D. R. D. S., Siqueira, R. D. A., Carlos, A. S., & Moreno, A. M. (2020) · Revista Brasileira de Ciências do Envelhecimento Humano · doi:10.5335/rbceh.v17i1.10543 · Cited by 9 · see citing works

Global research trends of immunosenescence: A bibliometric study

Chen, H., Luo, Y., Zhang, X., Luo, R., Bian, Y., Hou, Y., & Liu, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20362 · Cited by 7 · see citing works

Targeting aging hallmarks in brain health within the framework of preventive medicine: mechanistic insights into naringenin’s role in longevity, synaptic function, and cellular homeostasis

Zhi, Y., Xie, S., & Sun, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1680349 · Cited by 6 · see citing works

Immunogenicity and safety of reduced-antigen tetanus, diphtheria and acellular pertussis vaccination in adults treated for obstructive airway diseases

den Steen, P. V., Cheuvart, B., Deraedt, Q., Verelst, L., & Shamarina, D. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2159731 · Cited by 6 · see citing works

Immunization with Neural-Derived Peptides in Neurodegenerative Diseases: A Narrative Review

Monroy, G. R., Pérez, R. M., Ben-Zión, E. W., Alcantar-Garibay, O., Loza-López, E. C., Marion, E. T., Blancarte-Hernández, E., Navarro-Torres, L. K., & Ibarra, A. (2023) · Biomedicines · doi:10.3390/biomedicines11030919 · Cited by 6 · see citing works

Calorie restriction modulates neuro-immune system differently in young and aged rats

Chakraborty, A., Banerjee, S., Mukherjee, B., Poddar, M. K., & Ali, N. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108141 · Cited by 6 · see citing works

Plin2 Coordinates Immune and Metabolic Reprogramming in Lacrimal Gland Aging

Pei, X., Xuan, S., Yang, J., Ba, M., Yang, T., Huang, D., Qi, D., Lu, D., Huang, S., & Li, Z. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.6.79 · Cited by 5 · see citing works

Proteomic signature profiling in the cortex of dairy cattle unravels the physiology of brain aging

Cozzolino, F., Canè, L., Gatto, M. C., Iacobucci, I., Sacchettino, L., Biase, D. D., Napoli, E. D., Paciello, O., Avallone, L., Monti, M., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1277546 · Cited by 5 · see citing works

Immunosenescence as a convergence pathway in neurodegeneration

Mohapatra, L., Mishra, D. K., Tripathi, A. S., & Parida, S. K. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110521 · Cited by 36 · see citing works

Neurosenescence, inflammaging and neuroinflammation in neurodegenerative disorders

Kempuraj, D., Babu, P. R. R., Jayakumar, N., Belur, M. G., Cohan, C. H., Sharma, A., Sanchez-Guerrero, E., Anderson, T., Kong, D., Chinnappan, B., et al. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1756670 · Cited by 5 · see citing works

Immune aging, dysmetabolism, and inflammation in neurological diseases

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Immune Senescence and Inflammaging in Neurological Diseases

Baden, P., Cicco, S. D., Yu, C., & Deleidi, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_143-1

Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition

Benedetto, S. D., & Müller, L. (2019) · Springer eBooks · doi:10.1007/978-3-030-16073-9_14 · Cited by 11 · see citing works