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Cited by 532Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease

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Newcombe, Estella A., Camats-Perna, Judith, Silva, Mallone L., Valmas, Nicholas, Huat, Tee Jong, Medeiros, Rodrigo·2018·Journal of Neuroinflammation
DOI 10.1186/s12974-018-1313-3PMC PMC6154824
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear causative event. This has made the disease difficult to characterize and, thus, diagnose. Although some cases are genetically linked, there are many diseases and lifestyle factors that can lead to an increased risk of developing AD, including traumatic brain injury, diabetes, hypertension, obesity, and other metabolic syndromes, in addition to aging. Identifying common factors and trends between these conditions could enhance our understanding of AD and lead to the development of more effective treatments. Although the immune system is one of the body's key defense mechanisms, chronic inflammation has been increasingly linked with several age-related diseases. Moreover, it is now well accepted that chronic inflammation has an important role in the onset and progression of AD. In this review, the different inflammatory signals associated with AD and its risk factors will be outlined to demonstrate how chronic inflammation may be influencing individual susceptibility to AD. Our goal is to bring attention to potential shared signals presented by the immune system during different conditions that could lead to the development of successful treatments.

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  • Disrupted immune function is a potential link between metabolic and neurodegenerative disease states.

    “Intriguingly, it has been suggested that disrupted immune function is a potential link between these disease states (Pugazhenthi et al., 2017; Newcombe et al., 2018).”

    From Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice (2022) · cites this paper as Newcombe et al., 2018

  • Metabolomic biomarkers such as reduced docosahexaenoic acid (DHA) and elevated homocysteine have demonstrated clinical utility.

    “Despite variability introduced by diet and comorbid conditions, metabolomic biomarkers such as reduced docosahexaenoic acid (DHA) and elevated homocysteine have demonstrated clinical utility133,194, 195, 196, 197, 198, 199.”

    From Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions (2025) · cites this paper as [198]

    The section “The metabolic disorders and AD” (page unavailable) discusses diet, metabolic conditions, and inflammation, but not the clinical utility of metabolomic biomarkers. Searches for docosahexaenoic acid, homocysteine, and metabolomic biomarkers found no passage addressing the claimed markers or their clinical utility. (LLM, conf=0.73)

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Sorted by citations

Authors
Newcombe, E. A., Camats-Perna, J., Silva, M. L., Valmas, N., Huat, T. J., & Medeiros, R.
Affiliations
The University of Queensland (AU)
Corresponding author
  • Newcombe, Estella A.
  • Medeiros, Rodrigo
ORCID
Venue
Journal of Neuroinflammation
Publisher
Springer Science and Business Media LLC
Published
2018-09-24
Volume
15
Issue
1
Pages
276-276
ISSN
1742-2094 (ISSN-L)
DOI
10.1186/s12974-018-1313-3
PMC
PMC6154824
OpenAlex
W2891379852
Cited by
532
References
77
Citations by year
2026: 29 · 2025: 52 · 2024: 80 · 2023: 84 · 2022: 96 · 2021: 95 · 2020: 65 · 2019: 29 · 2018: 1
FWCI
4.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroinflammation (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Health and Medical Research Council (GNT1128436, GNT1129192, GNT1139469)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, chronic inflammation, comorbidities, genetic susceptibility, traumatic brain injury, diabetes mellitus, hypertension, obesity, metabolic syndrome, aging, neuroinflammation, immune system, risk factors, neurodegeneration
MeSH terms
Aging, Alzheimer Disease, Astrocytes, Brain, Humans, Inflammation, Neurons

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