The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Alzheimer’s disease and hippocampal adult neurogenesis; exploring shared mechanisms
Open accessAbstract
New neurons incorporate into the granular cell layer of the dentate gyrus throughout life. Neurogenesis is modulated by behavior and plays a major role in hippocampal plasticity. Along with older mature neurons, new neurons structure the dentate gyrus, and determine its function. Recent data suggest that the level of hippocampal neurogenesis is substantial in the human brain, suggesting that neurogenesis may have important implications for human cognition. In support of that, impaired neurogenesis compromises hippocampal function and plays a role in cognitive deficits in Alzheimer's disease mouse models. We review current work suggesting that neuronal differentiation is defective in Alzheimer's disease, leading to dysfunction of the dentate gyrus. Additionally, alterations in critical signals regulating neurogenesis, such as presenilin-1, Notch 1, soluble amyloid precursor protein, CREB, and β-catenin underlie dysfunctional neurogenesis in Alzheimer's disease. Lastly, we discuss the detectability of neurogenesis in the live mouse and human brain, as well as the therapeutic implications of enhancing neurogenesis for the treatment of cognitive deficits and Alzheimer's disease.
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“AD is characterized by progressive memory loss and cognitive dysfunction, and age-dependent decline in neurogenesis may compromise the structure and function of the hippocampus over time, leading to susceptibility to memory impairment (Hollands et al., 2016).”
From Multimodal MRI combined with RNA sequencing reveals pathological signatures in the 9-month-old 3×Tg-AD mouse brain (2026) · cites this paper as Hollands et al., 2016
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Metadata
- Authors
- Hollands, C., Bartolotti, N., & Lazarov, O.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Lazarov, Orly
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2016-05-03
- Volume
- 10
- Pages
- 178-178
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC4853383
- OpenAlex
- W2346727851
- Semantic Scholar
- 39dbd75fcd997404fa79a28cdaa96b3e22410e2e
- Cited by
- 160
- References
- 109
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 12 · 2023: 11 · 2022: 9 · 2021: 13 · 2020: 31 · 2019: 26 · 2018: 29 · 2017: 18 · 2016: 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (R01AG033570, 1RC1AG036208-01 ARR)
- U.S. Department of Defense (10917352)
- Center for Clinical and Translational Science, University of Illinois at Chicago (CCTS-0512-06)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, adult hippocampal neurogenesis, dentate gyrus, neuronal differentiation, presenilin 1, Notch1 signaling, CREB, β-catenin, hippocampal plasticity, cognitive impairment
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