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Alzheimer’s disease and hippocampal adult neurogenesis; exploring shared mechanisms
Open accessAbstract
New neurons incorporate into the granular cell layer of the dentate gyrus throughout life. Neurogenesis is modulated by behavior and plays a major role in hippocampal plasticity. Along with older mature neurons, new neurons structure the dentate gyrus, and determine its function. Recent data suggest that the level of hippocampal neurogenesis is substantial in the human brain, suggesting that neurogenesis may have important implications for human cognition. In support of that, impaired neurogenesis compromises hippocampal function and plays a role in cognitive deficits in Alzheimer's disease mouse models. We review current work suggesting that neuronal differentiation is defective in Alzheimer's disease, leading to dysfunction of the dentate gyrus. Additionally, alterations in critical signals regulating neurogenesis, such as presenilin-1, Notch 1, soluble amyloid precursor protein, CREB, and β-catenin underlie dysfunctional neurogenesis in Alzheimer's disease. Lastly, we discuss the detectability of neurogenesis in the live mouse and human brain, as well as the therapeutic implications of enhancing neurogenesis for the treatment of cognitive deficits and Alzheimer's disease.
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“AD is characterized by progressive memory loss and cognitive dysfunction, and age-dependent decline in neurogenesis may compromise the structure and function of the hippocampus over time, leading to susceptibility to memory impairment (Hollands et al., 2016).”
From Multimodal MRI combined with RNA sequencing reveals pathological signatures in the 9-month-old 3×Tg-AD mouse brain (2026) · cites this paper as Hollands et al., 2016
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Cites
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Kopan, R., & Ilagan, M. X. G. (2009) · Cell · doi:10.1016/j.cell.2009.03.045 · Cited by 3,764
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,588
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587
Sato, N., Meijer, L., Skaltsounis, A., Greengard, P., & Brivanlou, A. H. (2003) · Nature Medicine · doi:10.1038/nm979 · Cited by 2,139
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
Wnt signalling regulates adult hippocampal neurogenesis
Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,544
GABA regulates synaptic integration of newly generated neurons in the adult brain
Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,303
Neurogenesis in the adult hippocampus
Kempermann, G., Song, H., & Gage, F. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018812 · Cited by 1,072
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054
Increased hippocampal neurogenesis in Alzheimer's disease
Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2634794100 · Cited by 971
Neurogenesis in the striatum of the adult human brain
Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., Possnert, G., Druid, H., & Frisén, J. (2014) · Cell · doi:10.1016/j.cell.2014.01.044 · Cited by 937
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
Kandel, E. R. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-14 · Cited by 931
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
Lazarov, O., Robinson, J., Tang, Y.-P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M.-Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K., & Sisodia, S. S. (2005) · Cell · doi:10.1016/j.cell.2005.01.015 · Cited by 885
Self-citationPhysical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
Ahlskog, J. E., Geda, Y. E., Graff-Radford, N. R., & Petersen, R. C. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0252 · Cited by 885
Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704
Vitolo, O. V., Sant'Angelo, A., Costanzo, V., Battaglia, F., Arancio, O., & Shelanski, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172504199 · Cited by 534
Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499
Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain
Manganas, L. N., Zhang, X., Li, Y., Hazel, R. D., Smith, S. D. B., Wagshul, M. E., Henn, F. A., Benveniste, H., Djurić, P. M., Enikolopov, G., et al. (2007) · Science · doi:10.1126/science.1147851 · Cited by 495
Age-related memory deficits linked to circuit-specific disruptions in the hippocampus
Yassa, M. A., Mattfeld, A. T., Stark, S. M., & Stark, C. E. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101567108 · Cited by 476
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438
When neurogenesis encounters aging and disease
Lazarov, O., Mattson, M. P., Peterson, D. A., Pimplikar, S. W., & van Praag, H. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.09.003 · Cited by 405
Self-citationPresenilin: Running with Scissors in the Membrane
Selkoe, D. J., & Wolfe, M. S. (2007) · Cell · doi:10.1016/j.cell.2007.10.012 · Cited by 379
Rodríguez, J. J., Jones, V. C., Tabuchi, M., Allan, S. M., Knight, E. M., LaFerla, F. M., Oddo, S., & Verkhratsky, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002935 · Cited by 377
Young-Pearse, T. L., Bai, J., Chang, R., Zheng, J. B., LoTurco, J. J., & Selkoe, D. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4701-07.2007 · Cited by 369
Notch in the Vertebrate Nervous System: An Old Dog with New Tricks
Pierfelice, T. J., Alberi, L. A., & Gaiano, N. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.031 · Cited by 365
Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
Brickman, A. M., Khan, U., Provenzano, F. A., Yeung, L., SUZUKI, W. A., Schroeter, H., Wall, M. M., Sloan, R. P., & Small, S. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3850 · Cited by 354
Discovery of a Proneurogenic, Neuroprotective Chemical
Pieper, A. A., Xie, S., Capota, E., Estill, S. J., Zhong, J., Long, J. M., Becker, G. L., Huntington, P. J., Goldman, S. E., Shen, C.-H., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.018 · Cited by 351
Neurogenesis and Alzheimer's disease: At the crossroads
Lazarov, O., & Marr, R. A. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.009 · Cited by 340
Self-citationJagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Keßler, T., Saxe, M., Gage, F. H., Song, H., & Lie, D. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1054-09.2009 · Cited by 336
Demars, M., Hu, Y., Gadadhar, A., & Lazarov, O. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22387 · Cited by 326
Self-citationHippocampal neurogenesis: Learning to remember
Lazarov, O., & Hollands, C. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.006 · Cited by 297
Self-citationOrtega‐Martínez, S. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00046 · Cited by 285
Hattiangady, B., & Shetty, A. K. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.015 · Cited by 258
Associative Learning Elicits the Formation of Multiple-Synapse Boutons
Geinisman, Y., Berry, R. W., Disterhoft, J. F., Power, J., & van der Zee, E. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05568.2001 · Cited by 258
Chenn, A. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.599 · Cited by 253
Caccamo, A., Maldonado, M. A., Bokov, A. F., Majumder, S., & Oddo, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012851108 · Cited by 249
Visual object pattern separation deficits in nondemented older adultsPreprint
Toner, C. K., Pirogovsky, E., Kirwan, C. B., & Gilbert, P. E. (2009) · Learning & Memory · doi:10.1101/lm.1315109 · Cited by 245
Presenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin
Kang, D. E., Soriano, S., Xia, X., Eberhart, C. G., Strooper, B. D., Zheng, H., & Koo, E. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00970-4 · Cited by 236
Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis
Xia, X., Qian, S., Soriano, S., Wu, Y., Fletcher, A. M., Wang, X., Koo, E. H., Wu, X., & Zheng, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191284198 · Cited by 236
Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease
Xia, D., Watanabe, H., Wu, B., Lee, S. H., Li, Y., Tsvetkov, E., Bolshakov, V. Y., Shen, J., & Kelleher, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.010 · Cited by 234
Young-Pearse, T. L., Chen, A. C., Chang, R., Marquez, C., & Selkoe, D. J. (2008) · Neural Development · doi:10.1186/1749-8104-3-15 · Cited by 210
Klusmann, V., Evers, A., Schwarzer, R., Schlattmann, P., Reischies, F. M., Heuser, I., & Dimeo, F. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq053 · Cited by 210
Wang, R., Dineley, K. T., Sweatt, J. D., & Zheng, H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.048 · Cited by 207
Sun, B., Halabisky, B., Zhou, Y., Palop, J. J., Yu, G., Mucke, L., & Gan, L. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.10.003 · Cited by 205
Wen, P. H., Hof, P. R., Chen, X., Gluck, K., Austin, G., Younkin, S. G., Younkin, L. H., DeGasperi, R., Sosa, M. A. G., Robakis, N. K. R. K., et al. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.04.002 · Cited by 193
Shimizu, T., Kagawa, T., Inoue, T., Nonaka, A., Takada, S., Aburatani, H., & Taga, T. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01962-07 · Cited by 191
Stark, S. M., Yassa, M. A., & Stark, C. E. L. (2010) · Learning & Memory · doi:10.1101/lm.1768110 · Cited by 190
Testing the white matter retrogenesis hypothesis of cognitive aging
Brickman, A. M., Meier, I. B., Korgaonkar, M. S., Provenzano, F. A., Grieve, S. M., Siedlecki, K. L., Wasserman, B. T., Williams, L. M., & Zimmerman, M. E. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.001 · Cited by 177
Choi, S. H., Veeraraghavalu, K., Lazarov, O., Marler, S., Ransohoff, R. M., Ramirez, J., & Sisodia, S. S. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.033 · Cited by 176
Self-citationHu, Y., Xu, P., Pigino, G. F., Brady, S. T., Larson, J., & Lazarov, O. (2010) · The FASEB Journal · doi:10.1096/fj.09-136945 · Cited by 176
Self-citationCREB in adult neurogenesis – master and partner in the development of adult‐born neurons?
Merz, K., Herold, S., & Lie, D. C. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07606.x · Cited by 172
Development of Proneurogenic, Neuroprotective Small Molecules
MacMillan, K. S., Naidoo, J., Liang, J., Melito, L. M., Williams, N. S., Morlock, L., Huntington, P. J., Estill, S. J., Longgood, J. C., Becker, G. L., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja108211m · Cited by 170
Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum
Geinisman, Y., Ganeshina, O., Yoshida, R., Berry, R. W., Disterhoft, J. F., & Gallagher, M. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.001 · Cited by 166
Bitner, R. S. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.11.009 · Cited by 163
Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging
Silva-Vargas, V., Crouch, E. E., & Doetsch, F. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.09.004 · Cited by 157
Small-molecule activation of neuronal cell fate
Schneider, J. W., Gao, Z., Li, S., Farooqi, M. S., Tang, T.-S., Борисович, Б. И., Frantz, D. E., & Hsieh, J. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.95 · Cited by 151
Perturbed Neurogenesis in the Adult Hippocampus Associated with Presenilin-1 A246E Mutation
Chevallier, N. L., Soriano, S., Kang, D. E., Masliah, E., Hu, G., & Koo, E. H. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62962-8 · Cited by 145
Hu, Y.-S., Long, N., Pigino, G. F., Brady, S. T., & Lazarov, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064460 · Cited by 141
Self-citationSignaling in adult neurogenesis: from stem cell niche to neuronal networks
Ninkovic, J., & Götz, M. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.006 · Cited by 136
Hamilton, L. K., Aumont, A., Julien, C., Vadnais, A., Calon, F., & Fernandes, K. J. L. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07379.x · Cited by 127
Evidence of Aβ‐ and transgene‐dependent defects in ERK‐CREB signaling in Alzheimer’s models
Ma, Q., Harris‐White, M. E., Ubeda, O. J., Simmons, M., Beech, W. K., Lim, G. P., Teter, B., Frautschy, S. A., & Cole, G. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04869.x · Cited by 113
Essential role of tau phosphorylation in adult hippocampal neurogenesis
Hong, X., Peng, C., Wei, W., Tian, Q., Liu, Y., Yao, X., Zhang, Y., Cao, F., Wang, Q., & Wang, J. (2009) · Hippocampus · doi:10.1002/hipo.20712 · Cited by 112
Baulac, S., LaVoie, M. J., Kimberly, W. T., Strahle, J. M., Wolfe, M. S., Selkoe, D. J., & Xia, W. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00123-2 · Cited by 111
Neely, M. D., Litt, M. J., Tidball, A. M., Li, G. G., Aboud, A. A., Hopkins, C. R., Chamberlin, R., Hong, C. C., Ess, K. C., & Bowman, A. B. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300029t · Cited by 105
Demars, M. P., Bartholomew, A. M., Straková, Z., & Lazarov, O. (2011) · Stem Cell Research & Therapy · doi:10.1186/scrt77 · Cited by 102
Self-citationSmall molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells
Lange, C. M., Mix, E., Frahm, J., Glass, A. S., Müller, J. A., Schmitt, O., Schmöle, A., Klemm, K., Ortinau, S., Hübner, R., et al. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.10.076 · Cited by 100
Herold, S., Jagasia, R., Merz, K., Wassmer, K., & Lie, D. C. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.008 · Cited by 98
Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv mice
Porte, Y., Buhot, M.-C., & Mons, N. E. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.023 · Cited by 94
Neurogenesis in mouse models of Alzheimer's disease
Chuang, T. T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.12.008 · Cited by 88
Tau Protein and Adult Hippocampal Neurogenesis
Fuster-Matanzo, A., Llorens-Martı́n, M., Jurado‐Arjona, J., Ávila, J., & Hernández, F. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00104 · Cited by 85
All in the Family: How the APPs Regulate Neurogenesis
Lazarov, O., & Demars, M. P. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00081 · Cited by 81
Self-citationPresenilin-1 Regulates Neural Progenitor Cell Differentiation in the Adult Brain
Gadadhar, A., Marr, R. A., & Lazarov, O. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4767-10.2011 · Cited by 81
Self-citationA small molecule p75NTR ligand protects neurogenesis after traumatic brain injury
Shi, J., Longo, F. M., & Massa, S. M. (2013) · Stem Cells · doi:10.1002/stem.1516 · Cited by 81
Of mice and men: neurogenesis, cognition and Alzheimer’s disease
Lazarov, O., & Marr, R. A. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00043 · Cited by 78
Self-citationDemars, M. P., Hollands, C., Zhao, K., & Lazarov, O. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.016 · Cited by 77
Self-citationWang, W., Pan, Y.-W., Zou, J., Li, T., Abel, G. M., Palmiter, R. D., Storm, D. R., & Xia, Z. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3324-13.2014 · Cited by 76
Mcneish, J., Roach, M. L., Hambor, J., Mather, R., Weibley, L., Lazzaro, J., Gazard, J., Schwarz, J. A., Volkmann, R., Machacek, D., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.098814 · Cited by 74
Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease
Wahlster, L., Arimon, M., Nasser‐Ghodsi, N., Post, K. L., Serrano‐Pozo, A., Uemura, K., & Berezovska, O. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1065-6 · Cited by 72
Age-related disturbance of memory and CREB phosphorylation in CA1 area of hippocampus of rats
Kudo, K., Wati, H., Qiao, C., Arita, J., & Kanba, S. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.045 · Cited by 71
Functional and mechanistic exploration of an adult neurogenesis‐promoting small molecule
Petřík, D., Jiang, Y., Birnbaum, S. G., Powell, C. M., Kim, M., Hsieh, J., & Eisch, A. J. (2012) · The FASEB Journal · doi:10.1096/fj.11-201426 · Cited by 70
Human tau expression reduces adult neurogenesis in a mouse model of tauopathy
Komuro, Y., Xu, G., Bhaskar, K., & Lamb, B. T. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.03.002 · Cited by 64
Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus
Bullmann, T., de Silva, R., Holzer, M., Mori, H., & Arendt, T. (2006) · Hippocampus · doi:10.1002/hipo.20255 · Cited by 62
Tesco, G., Kim, T., Diehlmann, A., Beyreuther, K. T., & Tanzi, R. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.33909 · Cited by 60
The circulatory systemic environment as a modulator of neurogenesis and brain aging
Villeda, S., & Wyss‐Coray, T. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.10.014 · Cited by 57
Function of tau protein in adult newborn neurons
Fuster-Matanzo, A., de Barreda, E. G., Dawson, H. N., Vitek, M. P., Avila, J., & Hernández, F. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.08.017 · Cited by 57
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Research works printed but not linked: 1
- Lazarov, 2007, Research progress in Alzheimer's disease and dementia, 303
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Self-citation
Metadata
- Authors
- Hollands, C., Bartolotti, N., & Lazarov, O.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Lazarov, Orly
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2016-05-03
- Volume
- 10
- Pages
- 178-178
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC4853383
- OpenAlex
- W2346727851
- Semantic Scholar
- 39dbd75fcd997404fa79a28cdaa96b3e22410e2e
- Cited by
- 160
- References
- 109
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 12 · 2023: 11 · 2022: 9 · 2021: 13 · 2020: 31 · 2019: 26 · 2018: 29 · 2017: 18 · 2016: 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (R01AG033570, 1RC1AG036208-01 ARR)
- U.S. Department of Defense (10917352)
- Center for Clinical and Translational Science, University of Illinois at Chicago (CCTS-0512-06)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, adult hippocampal neurogenesis, dentate gyrus, neuronal differentiation, presenilin 1, Notch1 signaling, CREB, β-catenin, hippocampal plasticity, cognitive impairment
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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