The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Peripheral Neuron Survival and Outgrowth on Graphene
Open accessAbstract
Graphene displays properties that make it appealing for neuroregenerative medicine, yet its interaction with peripheral neurons has been scarcely investigated. Here, we culture on graphene two established models for peripheral neurons: PC12 cells and DRG primary neurons. We perform a nano-resolved analysis of polymeric coatings on graphene and combine optical microscopy and viability assays to assess the material cytocompatibility and influence on differentiation. We find that differentiated PC12 cells display a remarkably increased neurite length on graphene (up to 27%) with respect to controls. Notably, DRG primary neurons survive both on bare and coated graphene. They present dense axonal networks on coated graphene, while they form cell islets characterized by dense axonal bundles on uncoated graphene. These findings indicate that graphene holds potential for nerve tissue regeneration and might pave the road to novel concepts of active nerve conduits.
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The electronic properties of graphene
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Carbon nanotube coating improves neuronal recordings
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Revealing neuronal function through microelectrode array recordings
Obien, M. E. J., Deligkaris, K., Bullmann, T., Bakkum, D. J., & Frey, U. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00423 · Cited by 705
Neural tissue engineering options for peripheral nerve regeneration
Gu, X., Ding, F., & Williams, D. F. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.064 · Cited by 630
Kuzum, D., Takano, H., Shim, E., Reed, J. C., Juul, H., Richardson, A. G., de Vries, J., Bink, H., Dichter, M. A., Lucas, T. H., et al. (2014) · Nature Communications · doi:10.1038/ncomms6259 · Cited by 546
Cited by
Perez Ortiz, J. M., & Swerdlow, R. H. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14585 · Cited by 426
Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery
Zahin, N., Anwar, R., Tewari, D., Kabir, M. T., Sajid, A., Mathew, B., Uddin, M. S., Aleya, L., & Abdel-Daim, M. M. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-05211-0 · Cited by 371
Fake online reviews: Literature review, synthesis, and directions for future research
Wu, Y., Ngai, E. W. T., Wu, P., & Wu, C. (2020) · Decision Support Systems · doi:10.1016/j.dss.2020.113280 · Cited by 359
Exercise benefits on Alzheimer’s disease: State-of-the-science
Valenzuela, P. L., Castillo-García, A., Morales, J. S., de la Villa, P., Hampel, H., Emanuele, E., Lista, S., & Lucia, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101108 · Cited by 337
PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions
Wiatrak, B., Kubis-Kubiak, A., Piwowar, A., & Barg, E. (2020) · Cells · doi:10.3390/cells9040958 · Cited by 334
Metadata
- Authors
- Convertino, D., Luin, S., Marchetti, L., & Coletti, C.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-01-22
- Volume
- 12
- Pages
- 1-1
- ISSN
- 1662-453X (ISSN-L)
- OpenAlex
- W2622430872
- Cited by
- 511
- References
- 5
- FWCI
- 49.46
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
