Mitochondrial dysfunction in Alzheimer's disease: role in pathogenesis and novel therapeutic opportunities

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577 · see citing works

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165 · see citing works

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works

Cholinesterase inhibitors for Alzheimer's disease

Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906 · see citing works

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works

Extension of murine life span by overexpression of catalase targeted to mitochondria

Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724 · see citing works

BioVenn – a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams

Hulsen, T., de Vlieg, J., & Alkema, W. B. L. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-488 · Cited by 1,675 · see citing works

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

Harding, S. D., Sharman, J. L., Faccenda, E., Southan, C., Pawson, A. J., Ireland, S. M., Gray, A. J. G., Bruce, L., Alexander, S. P. H., Anderton, S. M., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1121 · Cited by 1,644 · see citing works

Metformin improves healthspan and lifespan in mice

Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works

Mitochondrial abnormalities in Alzheimer's disease

Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works

Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease

Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357 · see citing works

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303 · see citing works

NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · see citing works

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242 · see citing works

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224 · see citing works

Donepezil for dementia due to Alzheimer’s disease.

Birks, J. S., & Harvey, R. J. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001190.pub3 · Cited by 1,200 · see citing works

Memantine for dementia

McShane, R., Areosa Sastre, A., & Minakaran, N. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003154.pub5 · Cited by 1,155 · see citing works

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

Yao, J., Irwin, R. W., Zhao, L., Nilsen, J., Hamilton, R. T., & Brinton, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903563106 · Cited by 940 · see citing works

Positron Emission Tomography in Evaluation of Dementia

Silverman, D. H. S., Small, G. W., Chang, C. Y., Lu, C. S., de Aburto, M. A. K., Chen, W., Czernin, J. G., Rapoport, S. I., Pietrini, P., Alexander, G. E., et al. (2001) · JAMA · doi:10.1001/jama.286.17.2120 · Cited by 939 · see citing works

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm.1868 · Cited by 935 · see citing works

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

Sleiman, S. F., Henry, J., Al-Haddad, R., El Hayek, L., Abou Haidar, E., Stringer, T., Ulja, D., Karuppagounder, S. S., Holson, E. B., Ratan, R. R., et al. (2016) · eLife · doi:10.7554/elife.15092 · Cited by 810 · see citing works

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction

Devi, L., Prabhu, B. M., Galati, D. F., Avadhani, N. G., & Anandatheerthavarada, H. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-06.2006 · Cited by 792 · see citing works

The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives

Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · see citing works

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

Praticò, D., Uryu, K., Leight, S., Trojanoswki, J. Q., & Lee, V. M.-Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04183.2001 · Cited by 777 · see citing works

A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease

Swerdlow, R. H., & Khan, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.045 · Cited by 758 · see citing works

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works

Alzheimer's disease drug development pipeline: 2018

Cummings, J., Lee, G., Ritter, A., & Zhong, K. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.03.009 · Cited by 697 · see citing works

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease

Risner, M. E., Saunders, A. M., Altman, J. F. B., Ormandy, G. C., Craft, S., Foley, I. M., Zvartau-Hind, M. E., Hosford, D. A., Roses, A. D., & for the Rosiglitazone in Alzheimer's Disease Study Group (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500369 · Cited by 686 · see citing works

REGIONAL CEREBRAL OXYGEN SUPPLY AND UTILIZATION IN DEMENTIA: A CLINICAL AND PHYSIOLOGICAL STUDY WITH OXYGEN-15 AND POSITRON TOMOGRAPHY A CLINICAL AND PHYSIOLOGICAL STUDY WITH OXYGEN - 15 AND POSITRON TOMOHRAPHY

Frackowiak, R. S. J., Pozzilli, C., Legg, N. J., du Boulay, G. H., MARSHALL, J., Lenzi, G. L., & Jones, T. (1981) · Brain · doi:10.1093/brain/104.4.753 · Cited by 685 · see citing works

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

Rhein, V., Song, X., Wiesner, A., Ittner, L. M., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Dröse, S., Brandt, U., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905529106 · Cited by 655 · see citing works

The mitochondrial energy transduction system and the aging process

Navarro, A., & Boveris, A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00213.2006 · Cited by 646 · see citing works

Origin and functional consequences of the complex I defect in Parkinson's disease

Swerdlow, R. H., Parks, J. K., Miller, S. W., Davis, R. E., Tuttle, J. B., Trimmer, P. A., Sheehan, J. P., Bennett, J. P., & Parker, W. D. (1996) · Annals of Neurology · doi:10.1002/ana.410400417 · Cited by 638 · see citing works

Intermittent metabolic switching, neuroplasticity and brain health

Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.156 · Cited by 624 · see citing works

Cytochrome oxidase deficiency in Alzheimer’s disease

Parker, W. D., Filley, C. M., & Parks, J. K. (1990) · Neurology · doi:10.1212/wnl.40.8.1302 · Cited by 598 · cited 1× · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

Alexander, S. P. H., Fabbro, D., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13877 · Cited by 597 · see citing works

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

Li, Y., Perry, T., Kindy, M. S., Harvey, B. K., Tweedie, D., Holloway, H. W., Powers, K., Shen, H., Egan, J. M., Sambamurti, K., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806720106 · Cited by 589 · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: g protein-coupled receptors

Alexander, S. P., Christopoulos, A., Davenport, A. P., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13878 · Cited by 588 · see citing works

Evolutionary medicine: from dwarf model systems to healthy centenarians?

Longo, V. D., & Finch, C. E. (2003) · Science · doi:10.1126/science.1077991 · Cited by 575 · see citing works

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

Anandatheerthavarada, H. K., Biswas, G., Robin, M.-A., & Avadhani, N. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207030 · Cited by 571 · see citing works

Alzheimer's disease drug development pipeline: 2017

Cummings, J., Lee, G., Mortsdorf, T., Ritter, A., & Zhong, K. (2017) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.05.002 · Cited by 549 · see citing works

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

Henderson, S. T., Vogel, J. L., Barr, L. J., Garvin, F., Jones, J. J., & Costantini, L. C. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-31 · Cited by 548 · see citing works

Alzheimer's disease

Foster, N. L., Chase, T. N., Fedio, P., Patronas, N. J., Brooks, R. A., & Chiro, G. D. (1983) · Neurology · doi:10.1212/wnl.33.8.961 · Cited by 540 · see citing works

Rivastigmine for Alzheimer’s disease.

Birks, J. S., Chong, L.-Y., & Grimley Evans, J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001191.pub4 · Cited by 534 · see citing works

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

Mutisya, E. M., Bowling, A. C., & Beal, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062179.x · Cited by 531 · see citing works

Peripheral Neuron Survival and Outgrowth on Graphene

Convertino, D., Luin, S., Marchetti, L., & Coletti, C. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00001 · Cited by 516 · see citing works

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

Maurer, I. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00112-3 · Cited by 475 · see citing works

NAD ⁺ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718819115 · Cited by 472 · see citing works

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

Hauptmann, S., Scherping, I., Dröse, S., Brandt, U., Schulz, K. L., Jendrach, M., Leuner, K., Eckert, A., & Müller, W. E. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.005 · Cited by 469 · see citing works

Regional Cerebral Metabolic Alterations in Dementia of the Alzheimer Type

Friedland, R. P., Budinger, T. F., Ganz, E., Yano, Y., Mathis, C. A., Koss, B., Ober, B. A., Huesman, R. H., & Derenzo, S. (1983) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198308000-00003 · Cited by 468 · see citing works

Drug development in Alzheimer’s disease: the path to 2025

Cummings, J., Aisen, P. S., DuBois, B., Frölich, L., Jack, C. R., Jones, R. W., Morris, J. C., Raskin, J., Dowsett, S. A., & Scheltens, P. (2016) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0207-9 · Cited by 459 · see citing works

Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

Kaźmierczak-Barańska, J., Boguszewska, K., Adamus-Grabicka, A., & Karwowski, B. T. (2020) · Nutrients · doi:10.3390/nu12051501 · Cited by 455 · see citing works

Metabolic network failures in Alzheimer's disease: A biochemical road map

Toledo, J. B., Arnold, M., Kastenmüller, G., Chang, R. R., Baillie, R., Han, X., Thambisetty, M., Tenenbaum, J. D., Suhre, K., Thompson, J. W., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.01.020 · Cited by 454 · see citing works

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

Veitch, D. P., Weiner, M. W., Aisen, P. S., Beckett, L. A., Cairns, N. J., Green, R. C., Harvey, D., Jack, C. R., Jagust, W., Morris, J. C., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.08.005 · Cited by 454 · see citing works

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

David, D. C., Hauptmann, S., Scherping, I., Schuessel, K., Keil, U., Rizzu, P., Ravid, R., Dröse, S., Brandt, U., Müller, W. E., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500356200 · Cited by 447 · see citing works

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease

McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432 · see citing works

Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

Green, K. N., Steffan, J. S., Martinez-Coria, H., Sun, X., Schreiber, S. S., Thompson, L. M., & LaFerla, F. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3203-08.2008 · Cited by 404 · see citing works

Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging

Kalpouzos, G., Chételat, G., Baron, J.-C., Landeau, B., Mevel, K., Godeau, C., Barré, L., Constans, J.-M., Viader, F., Eustache, F., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.019 · Cited by 392 · cited 1× · see citing works

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

Gabuzda, D., Busciglio, J., Chen, L. B., Matsudaira, P., & Yankner, B. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36875-8 · Cited by 373 · see citing works

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

Ou, Z., Kong, X., Sun, X., He, X., Zhang, L., Gong, Z., Huang, J., Xu, B., Long, D., Li, J., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.12.009 · Cited by 370 · see citing works

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

Kashiwaya, Y., Bergman, C., Lee, J.-H., Wan, R., King, M. T., Mughal, M. R., Okun, E., Clarke, K., Mattson, M. P., & Veech, R. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.023 · Cited by 363 · see citing works

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

Gold, M., Alderton, C., Zvartau-Hind, M., Egginton, S., Saunders, A. M., Irizarry, M., Craft, S., Landreth, G., Linnamägi, Ü., & Sawchak, S. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000318845 · Cited by 361 · see citing works

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, R., Moreira, P. I., Proença, T., Deshpande, A., Busciglio, J., Pereira, C., & Oliveira, C. R. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.012 · Cited by 343 · see citing works

Galantamine for Alzheimer's disease and mild cognitive impairment

Loy, C. T., & Schneider, L. S. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001747.pub3 · Cited by 335 · see citing works

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

Pedersen, W. A., McMillan, P. J., Kulstad, J. J., Leverenz, J. B., Craft, S., & Haynatzki, G. R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.018 · Cited by 321 · see citing works

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

Chang, S., Ma, T. R., Miranda, R. D., Balestra, M. E., Mahley, R. W., & Huang, Y. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508254102 · Cited by 319 · see citing works

GLP-1 Receptor Stimulation Reduces Amyloid-β Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer's Disease

Li, Y., Duffy, K. B., Ottinger, M. A., Ray, B., Bailey, J. A., Holloway, H. W., Tweedie, D., Perry, T., Mattson, M. P., Kapogiannis, D., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1314 · Cited by 319 · see citing works

The development of mitochondrial medicine.

Luft, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8731 · Cited by 302 · see citing works

Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

Weissman, L., Jo, D.-G., Sorensen, M. M., de Souza-Pinto, N. C., Markesbery, W. R., Mattson, M. P., & Bohr, V. A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm605 · Cited by 299 · see citing works

Pre-Clinical Detection of Alzheimer's Disease Using FDG-PET, with or without Amyloid Imaging

Mosconi, L., Berti, V., Glodzik, L., Pupi, A., Santi, S. D., & de Leon, M. J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091504 · Cited by 279 · see citing works

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

Kopeikina, K. J., Carlson, G. A., Pitstick, R., Ludvigson, A. E., Peters, A., Luebke, J. I., Koffie, R. M., Frosch, M. P., Hyman, B. T., & Spires‐Jones, T. L. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.07.004 · Cited by 276 · see citing works

Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease

Taylor, M., Sullivan, D. K., Mahnken, J. D., Burns, J. M., & Swerdlow, R. H. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.11.002 · Cited by 273 · see citing works

Cybrids in Alzheimer's disease: a cellular model of the disease?

Swerdlow, R. H., Parks, J. K., Cassarino, D. S., Maguire, D. J., Maguire, R. S., Bennett, J. P., Davis, R. E., & Parker, W. D. (1997) · Neurology · doi:10.1212/wnl.49.4.918 · Cited by 272 · see citing works

Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

Wang, J., Markesbery, W. R., & Lovell, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03615.x · Cited by 260 · see citing works

Cybrids in Alzheimer's disease: A cellular model of the disease?

Swerdlow, R. H., & Parker, D. W. (1998) · Neurology · doi:10.1212/wnl.51.1.326-a · Cited by 260 · see citing works

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

Gibson, G. E., Starkov, A. A., Blass, J. P., Ratan, R. R., & Beal, M. F. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.010 · Cited by 256 · see citing works

Rivastigmine for Alzheimer's disease

Birks, J., & Evans, J. G. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001191.pub3 · Cited by 247 · see citing works

3‐Hydroxybutyrate regulates energy metabolism and induces <scp>BDNF</scp> expression in cerebral cortical neurons

Marosi, K., Kim, S. W., Moehl, K., Scheibye‐Knudsen, M., Cheng, A., Cutler, R., Camandola, S., & Mattson, M. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13868 · Cited by 242 · see citing works

Altered cerebral energy metabolism in Alzheimer's disease: a PET study.

Fukuyama, H., Ogawa, M., Yamauchi, H., Yamaguchi, S., Kimura, J., Yonekura, Y., & Konishi, J. (1994) · PubMed · Cited by 228 · see citing works

Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease

Cunnane, S. C., Courchesne‐Loyer, A., Vandenberghe, C., St‐Pierre, V., Fortier, M., Hennebelle, M., Croteau, É., Bocti, C., Fülöp, T., & Castellano, C. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00053 · Cited by 224 · see citing works

Vitamin E Paradox in Alzheimer's Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental

Lloret, A., Badía, M.-C., Mora, N. J., Pallardó, F. V., Alonso, M.-D., & Viña, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1033 · Cited by 222 · see citing works

Drug and Exercise Treatment of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Effects on Cognition in Randomized Controlled Trials

Ströhle, A., Schmidt, D. K., Schultz, F., Fricke, N., Staden, T., Hellweg, R., Priller, J., Rapp, M. A., & Rieckmann, N. (2015) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2015.07.007 · Cited by 212 · see citing works

The Alzheimer's disease mitochondrial cascade hypothesis: an update

Swerdlow, R. H., & Khan, S. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.01.011 · Cited by 206 · see citing works

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

Buggia-Prévot, V., Fernandez, C., Riordan, S. M., Vetrivel, K. S., Roseman, J., Waters, J., Bindokas, V. P., Vassar, R. J., & Thinakaran, G. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-1 · Cited by 201 · see citing works

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

Harrington, C. M., Sawchak, S. T., Chiang, C., Davies, J., Donovan, C., Saunders, A. M., Irizarry, M. C., Jeter, B., Zvartau-Hind, M. E., van Dyck, C. H., et al. (2011) · Current Alzheimer Research · doi:10.2174/156720511796391935 · Cited by 198 · see citing works

Gene Transfer of Human <i>Apoe</i> Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

Hudry, E., Dashkoff, J., Roe, A. D., Takeda, S., Koffie, R. M., Hashimoto, T., Scheel, M., Spires-Jones, T., Arbel-Ornath, M., Betensky, R., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007000 · Cited by 187 · see citing works

Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons

Fukui, H., & Moraes, C. T. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn437 · Cited by 185 · see citing works

Rosiglitazone Induces Mitochondrial Biogenesis in Mouse Brain

Strum, J. C., Shehee, R., Virley, D. J., Richardson, J. C., Mattie, M. D., Selley, P., Ghosh, S., Nock, C. M., Saunders, A. M., & Roses, A. D. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11108 · Cited by 183 · see citing works

Mitochondrial function in brain tissue in primary degenerative dementia

Sims, N. R., Finegan, J. M., Blass, J. P., Bowen, D. M., & Neary, D. (1987) · Brain Research · doi:10.1016/0006-8993(87)91553-8 · Cited by 182 · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Catalytic receptors

Alexander, S. P. H., Fabbro, D., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13876 · Cited by 177 · see citing works

Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways.

Khan, S. M., Cassarino, D. S., Abramova, N. N., Keeney, P. M., Borland, M. K., Pa, T., Krebs, C. T., Bennett, J. C., Parks, J. K., Swerdlow, R. H., et al. (2000) · PubMed · Cited by 176 · see citing works

Decreased base excision repair and increased helicase activity in Alzheimer's disease brain

Lovell, M. A., Xie, C., & Markesbery, W. R. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02335-5 · Cited by 174 · see citing works

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

Mao, P., Mańczak, M., Calkins, M. J., Truong, Q., Reddy, T. P., Reddy, A. P., Shirendeb, U. P., Lo, H., Rabinovitch, P. S., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds128 · Cited by 174 · see citing works

Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

Quintanilla, R. A., Matthews-Roberson, T. A., Dolan, P. J., & Johnson, G. V. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808908200 · Cited by 170 · see citing works

The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer’s disease: an overview of pre-clinical studies and translational perspectives in clinical practice

Cascella, M., Bimonte, S., Muzio, M. R., Schiavone, V., & Cuomo, A. (2017) · Infectious Agents and Cancer · doi:10.1186/s13027-017-0145-6 · Cited by 167 · see citing works

Novel ketone diet enhances physical and cognitive performance

Murray, A. J., Knight, N. S., Cole, M. A., Cochlin, L. E., Carter, E., Tchabanenko, K., Pichulik, T., Gulston, M. K., Atherton, H. J., Schroeder, M., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600773r · Cited by 165 · see citing works

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

Eckert, A., Schulz, K. L., Rhein, V. F., & Götz, J. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8109-5 · Cited by 158 · see citing works

Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology

Beeri, M. S., Schmeidler, J., Silverman, J. M., Gandy, S., Wysocki, M., Hannigan, C. M., Purohit, D. P., Lesser, G., Grossman, H. T., & Haroutunian, V. (2008) · Neurology · doi:10.1212/01.wnl.0000324925.95210.6d · Cited by 157 · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand‐gated ion channels

Alexander, S. P. H., Peters, J. A., Kelly, E., Marrion, N. V., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Davies, J. A., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13879 · Cited by 157 · see citing works

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

Maria Jose Perez, J., Jara, C., & Quintanilla, R. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00441 · Cited by 153 · see citing works

Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

Valla, J., Yaari, R., Wolf, A. B., Kusne, Y., Beach, T. G., Roher, A. E., Corneveaux, J. J., Huentelman, M. J., Caselli, R. J., & Reiman, E. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100129 · Cited by 150 · see citing works

Age, sex and laterality effects on cerebral glucose metabolism in healthy adults

Willis, M. W., Ketter, T. A., Kimbrell, T. A., George, M. S., Herscovitch, P., Danielson, A. L., Benson, B. E., & Post, R. M. (2002) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00126-3 · Cited by 150 · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Nuclear hormone receptors

Alexander, S. P. H., Cidlowski, J. A., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13880 · Cited by 138 · see citing works

Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance

Chen, J., Luo, C., Pu, D., Zhang, G., Zhao, Y., Sun, Y., Zhao, K., Liao, Z., Lv, A., Zhu, S., et al. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.09.008 · Cited by 131 · see citing works

March separate, strike together — Role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease

Eckert, A., Nisbet, R. M., Grimm, A., & Götz, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.08.013 · Cited by 127 · see citing works

Multifactorial causal model of brain (dis)organization and therapeutic intervention: Application to Alzheimer’s disease

Iturria‐Medina, Y., Carbonell, F., Sotero, R. C., Chouinard-Decorte, F., & Evans, A. C. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.058 · Cited by 126 · see citing works

Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis

Wilkins, H., Harris, J. L., Carl, S. M., Lezi, E., Lu, J., Selfridge, J. E., Roy, N., Hutfles, L. J., Koppel, S. J., Morris, J. K., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu371 · Cited by 116 · see citing works

Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

Bonda, D., Wang, X., Lee, H., Smith, M. A., Perry, G. L., & Zhu, X. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1424-x · Cited by 113 · see citing works

Alzheimer's drug‐development pipeline: 2016

Cummings, J., Morstorf, T., & Lee, G. (2016) · Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions · doi:10.1016/j.trci.2016.07.001 · Cited by 108 · see citing works

Cybrids in Alzheimer's disease: A cellular model of the disease?

Schon, E. A., Shoubridge, E. A., & Moraes, C. T. (1998) · Neurology · doi:10.1212/wnl.51.1.326 · Cited by 101 · see citing works

The biochemical basis of mitochondrial diseases

Scholte, H. R. (1988) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00768393 · Cited by 97 · see citing works

Galantamine for Alzheimer’s Disease and Mild Cognitive Impairment

Cusi, C., Cantisani, T. A., Celani, M. G., Incorvaia, B., Righetti, E., & Candelise, L. (2007) · Neuroepidemiology · doi:10.1159/000101510 · Cited by 96 · see citing works

Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer’s disease

Krishnan, K. J., Ratnaike, T. E., De Gruyter, H. L. M., Jaros, E., & Turnbull, D. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.08.009 · Cited by 95 · see citing works

Mitochondrial Dysfunction in Cybrid Lines Expressing Mitochondrial Genes from Patients with Progressive Supranuclear Palsy

Swerdlow, R. H., Golbe, L. I., Parks, J. K., Cassarino, D. S., Binder, D. R., Grawey, A. E., Litvan, I., Bennett, J. P., Wooten, G. F., & Parker, W. D. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751681.x · Cited by 95 · see citing works

Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity

Chételat, G., Landeau, B., Salmon, E., Yakushev, I., Bahri, M. A., Mézenge, F., Perrotin, A., Bastin, C., Manrique, A., Scheurich, A., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.009 · Cited by 92 · see citing works

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease

Kukreja, L., Kujoth, G. C., Prolla, T. A., LEUVEN, F. V., & Vassar, R. J. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-16 · Cited by 86 · see citing works

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus

Jara, C., Aránguiz, A., Cerpa, W. F., Tapia‐Rojas, C., & Quintanilla, R. A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.07.010 · Cited by 84 · see citing works

Age-related changes in brain: II. Positron emission tomography of frontal and temporal lobe glucose metabolism in normal subjects

De Santi, S., de Leon, M. J., Convit, A., Tarshish, C., Rusinek, H., Tsui, W. H., Sinaiko, E., Wang, G.-J., Bartlet, E., & Volkow, N. (1995) · Psychiatric Quarterly · doi:10.1007/bf02238755 · Cited by 74 · see citing works

Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers

Perkins, M., Wolf, A. B., Chavira, B., Shonebarger, D., Meckel, J. P., Leung, L., Ballina, L. E., Ly, S., Saini, A., Jones, T. B., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151205 · Cited by 74 · see citing works

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

Cardoso, S., Carvalho, C., Correia, S. C., Seiça, R. M. F., & Moreira, P. I. (2016) · Brain Pathology · doi:10.1111/bpa.12402 · Cited by 67 · see citing works

Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease

Canugovi, C., Shamanna, R. A., Croteau, D. L., & Bohr, V. A. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.004 · Cited by 61 · see citing works

Potentiation of Brain Mitochondrial Function by S-equol and R/S-equol Estrogen Receptor β Selective PhytoSERM Treatments

Yao, J., Zhao, L.-Q., Mao, Z.-S., Chen, S.-H., Wong, K., To, J., & Brinton, R. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.021 · Cited by 61 · see citing works

Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients

Wilkins, H., Koppel, S. J., Bothwell, R. J., Mahnken, J. D., Burns, J. M., & Swerdlow, R. H. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.010 · Cited by 61 · see citing works

Rosiglitazone Improves Spatial Memory and Decreases Insoluble Aβ1–42 in APP/PS1 Mice

O’Reilly, J.-A., & Lynch, M. A. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9282-7 · Cited by 56 · see citing works

Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure

Wilkins, H., Koppel, S. J., Carl, S. M., Ramanujan, S., Weidling, I. W., Michaelis, M. L., Michaelis, E. K., & Swerdlow, R. H. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13545 · Cited by 55 · see citing works

A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer’s Disease Subjects: Results of a Single-Arm, Pilot Trial

Wilkins, H., Mahnken, J. D., Welch, P., Bothwell, R. J., Koppel, S. J., Jackson, R. L., Burns, J. M., & Swerdlow, R. H. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170077 · Cited by 51 · see citing works

Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer’s Disease-Like Pathology in OXYS Rats

Tyumentsev, M. A., Stefanova, N. A., Muraleva, N. A., Rumyantseva, Y. V., Владимировна, К. Е., Андреевич, В. В., & Kolosova, N. G. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180065 · Cited by 51 · see citing works

Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity

Choi, J., Chandrasekaran, K., Demarest, T. G., Kristián, T., Xu, S., Vijaykumar, K., Dsouza, K. G., Qi, N., Yarowsky, P., Gallipoli, R., et al. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.86 · Cited by 50 · see citing works

Bioenergetic medicine

Swerdlow, R. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12394 · Cited by 50 · see citing works

Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation

Pinto, M., Pickrell, A. M., Fukui, H., & Moraes, C. T. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.014 · Cited by 47 · see citing works

Mitochondrial medicine and the neurodegenerative mitochondriopathies

Swerdlow, R. H. (2009) · Pharmaceuticals · doi:10.3390/ph2030150 · Cited by 43 · see citing works

Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells

Yoon, S., Park, J.-S., Choi, J., Choi, J.-M., Lee, W.-J., Kim, S.-W., & Kim, D. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.07.005 · Cited by 42 · see citing works

Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects

Soltys, D. T., Pereira, C. P. M., Rowies, F. T., Farfel, J. M., Grinberg, L. T., Suemoto, C. K., Leite, R. E. P., Rodriguez, R. D., Ericson, N. G., Bielas, J. H., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.015 · Cited by 42 · see citing works

Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases

H. Swerdlow, R. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798072535 · Cited by 35 · see citing works

Quantitative Proteomic Analysis of Mitochondria in Aging PS-1 Transgenic Mice

Fu, Y.-J., Xiong, S., Lovell, M. A., & Lynn, B. C. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9359-5 · Cited by 35 · see citing works

Bioenergetics and metabolism: a bench to bedside perspective

Swerdlow, R. H. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13509 · Cited by 35 · see citing works

The Rat Prefrontal-Cortex Transcriptome: Effects of Aging and Sporadic Alzheimer’s Disease–Like Pathology

Stefanova, N. A., Ershov, N., Maksimova, K. Y., Muraleva, N. A., Tyumentsev, M. A., & Kolosova, N. G. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly198 · Cited by 32 · see citing works

Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus

Zhang, D., Mably, A. J., Walsh, D. M., & Rowan, M. J. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw193 · Cited by 29 · see citing works

Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer’s disease and normalized by treatment with anti-diabetic agents

Katsel, P., Roussos, P., Beeri, M. S., Gama-Sosa, M. A., Gandy, S., Khan, S., & Haroutunian, V. H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206547 · Cited by 29 · see citing works

Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease

Elkamhawy, A., Park, J.-E., Hassan, A. H. E., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.12.045 · Cited by 27 · see citing works

Safety and Tolerability of R(+) Pramipexole in Mild-to-Moderate Alzheimer’s Disease

Bennett, J. P., Burns, J. M., Welch, P., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150788 · Cited by 26 · see citing works

Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging

Marano, C. M., Workman, C. I., Kramer, E., Hermann, C. R., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D., & Smith, G. S. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3840 · Cited by 24 · see citing works

Tooth loss early in life induces hippocampal morphology remodeling in senescence-accelerated mouse prone 8 (SAMP8) mice

Katano, M., Kajimoto, K., Iinuma, M., Azuma, K., & Kubo, K. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.40241 · Cited by 22 · see citing works

Antioxidant and Anti-Apoptotic Activity of Octadecaneuropeptide Against 6-OHDA Toxicity in Cultured Rat Astrocytes

Kaddour, H., Hamdi, Y., Amri, F., et al. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1181-4 · Cited by 18 · see citing works

High-Throughput Small Molecule Screen Identifies Modulators of Mitochondrial Function in Neurons

Várkuti, B. H., Liu, Z., Képiró, M., Pacifico, R., Gai, Y., Kamenecka, T., & Davis, R. L. (2020) · iScience · doi:10.1016/j.isci.2020.100931 · Cited by 18 · see citing works

Anti-PDHA1 antibody is detected in a subset of patients with schizophrenia

Nakagami, Y., Sugihara, G., Nakashima, N., Hazama, M., Son, S., Ma, S., Matsumoto, R., Murai, T., Ikeda, A., & Murakami, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-63776-0 · Cited by 7 · see citing works

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Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y., & Matsuda, S. (2020) · Biomedical Reports · doi:10.3892/br.2020.1310 · Cited by 6 · see citing works

Theme 3 In vivo experimental models

(2017) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2017.1371517 · Cited by 1 · see citing works

Untitled work

Khan (2000) · doi:10.1002/1531-8249(200008)48:2

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Park, M. W., Cha, H. W., Kim, J., Kim, J. H., Yang, H., Yoon, S., Boonpraman, N., Yi, S. S., Yoo, I. D., & Moon, J.-S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101947 · Cited by 683 · see citing works

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Kaźmierczak-Barańska, J., Boguszewska, K., Adamus-Grabicka, A., & Karwowski, B. T. (2020) · Nutrients · doi:10.3390/nu12051501 · Cited by 455 · see citing works

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Liu, D., Gao, Y., Liu, J., Huang, Y., Yin, J., Feng, Y., Shi, L., Meloni, B. P., Zhang, C., Zheng, M., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00440-z · Cited by 403 · see citing works

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Nativio, R., Lan, Y., Donahue, G., Sidoli, S., Berson, A., Srinivasan, A. R., Shcherbakova, O., Amlie-Wolf, A., Nie, J., Cui, X., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0696-0 · Cited by 380 · see citing works

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Song, T., Song, X., Zhu, C., Patrick, R., Skurla, M., Santangelo, I., Green, M., Harper, D., Ren, B., Forester, B. P., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101503 · Cited by 346 · see citing works

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Lonnemann, N., Hosseini, S., Marchetti, C., Skouras, D. B., Stefanoni, D., D’Alessandro, A., Dinarello, C. A., & Korte, M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009680117 · Cited by 298 · see citing works

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Reich, N., & Hölscher, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.970925 · Cited by 248 · see citing works

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Tenchov, R., Sasso, J. M., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00339 · Cited by 170 · see citing works

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Edler, M. K., Mhatre-Winters, I., & Richardson, J. R. (2021) · Cells · doi:10.3390/cells10051138 · Cited by 126 · see citing works

The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer’s disease

Du, H., Meng, X., Yao, Y., & Xu, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1033479 · Cited by 125 · see citing works

Oxidative Damage and Antioxidant Response in Frontal Cortex of Demented and Nondemented Individuals with Alzheimer’s Neuropathology

Fracassi, A., Marcatti, M., Zolochevska, O., Tabor, N., Woltjer, R., Moreno, S., & Taglialatela, G. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.0295-20.2020 · Cited by 81 · see citing works

Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial

Yulug, B., Altay, O., Li, X., Hanoglu, L., Cankaya, S., Lam, S., Velioglu, H. A., Yang, H., Coskun, E., Idil, E., et al. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00336-2 · Cited by 79 · see citing works

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works

Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice

Malkov, A., Popova, I., Ivanov, A., Jang, S.-S., Yoon, S. Y., Osypov, A., Huang, Y., Zilberter, Y., & Zilberter, M. (2021) · Communications Biology · doi:10.1038/s42003-021-02551-x · Cited by 59 · see citing works

Impact of COVID-19 on Alzheimer’s Disease Risk: Viewpoint for Research Action

Abate, G., Memo, M., & Uberti, D. (2020) · Healthcare · doi:10.3390/healthcare8030286 · Cited by 56 · see citing works

ApoE4 attenuates autophagy via FoxO3a repression in the brain

Sohn, H.-Y., Kim, S.-I., Park, J.-Y., Park, S.-H., Koh, Y. H., Kim, J., & Jo, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-97117-6 · Cited by 54 · see citing works

Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond

Webber, E. K., Fivaz, M., Stutzmann, G. E., & Griffioen, G. (2023) · Alzheimer's &amp; Dementia · doi:10.1002/alz.13065 · Cited by 50 · see citing works

The Possible Application of Ketamine in the Treatment of Depression in Alzheimer’s Disease

Mohammad Shehata, I., Masood, W., Nemr, N., Anderson, A., Bhusal, K., Edinoff, A. N., Cornett, E. M., Kaye, A. M., & Kaye, A. D. (2022) · Neurology International · doi:10.3390/neurolint14020025 · Cited by 41 · see citing works

Mitochondria and Cellular Redox State on the Route from Ageing to Alzheimer's Disease

Abate, G., Vezzoli, M., Sandri, M., Rungratanawanich, W., Memo, M., & Uberti, D. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111385 · Cited by 41 · see citing works

A partial reduction of <scp>VDAC1</scp> enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model

Vijayan, M., Alvir, R. V., Alvir, R. V., Bunquin, L. E., Pradeepkiran, J. A., & Reddy, P. H. (2022) · Aging Cell · doi:10.1111/acel.13663 · Cited by 40 · see citing works

Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice

Bhatti, J. S., Tamarai, K., Kandimalla, R., Manczak, M., Yin, X., Ramasubramanian, B., Sawant, N., Pradeepkiran, J. A., Vijayan, M., Kumar, S., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.02.007 · Cited by 30 · see citing works

Pathogenesis, Animal Models, and Drug Discovery of Alzheimer’s Disease

Xia, Z.-D., Ma, R.-X., Wen, J.-F., Zhai, Y.-F., Wang, Y.-Q., Wang, F.-Y., Liu, D., Zhao, X.-L., Sun, B., Jia, P., et al. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-230326 · Cited by 19 · see citing works

Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms

Yang, Y., & Wang, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170788 · Cited by 46 · see citing works

Disease-associated protein seeding suggests a dissociation between misfolded protein accumulation and neurodegeneration in prion disease

Alibhai, J. D., Diack, A. B., & Manson, J. C. (2017) · Prion · doi:10.1080/19336896.2017.1378289 · Cited by 5 · see citing works

A Possible Neurodegeneration Mechanism Triggered by Diabetes

Farhadi, A., Vosough, M., Zhang, J., Tahamtani, Y., & Shahpasand, K. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.012 · Cited by 31 · see citing works

Mitochondrial protein import stress augments α-synuclein aggregation and neurodegeneration independent of bioenergeticsPreprint

Coyne, L. P., Rana, A., Wang, X., Bhagwagar, S. Z., Umino, Y., Solessio, E. C., Middleton, F. A., & Chen, X. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.20.508793 · Cited by 3 · see citing works

Assessing Mitochondrial Bioenergetics in Isolated Mitochondria from Mouse Heart Tissues Using Oroboros 2k-Oxygraph

Long, Q., Huang, L., Huang, K., & Yang, Q. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9195-2_19 · Cited by 53 · see citing works