Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging
Open accessAbstract
Calcium imaging is a versatile experimental approach capable of resolving single neurons with single-cell spatial resolution in the brain. Electrophysiological recordings provide high temporal, but limited spatial resolution, because of the geometrical inaccessibility of the brain. An approach that integrates the advantages of both techniques could provide new insights into functions of neural circuits. Here, we report a transparent, flexible neural electrode technology based on graphene, which enables simultaneous optical imaging and electrophysiological recording. We demonstrate that hippocampal slices can be imaged through transparent graphene electrodes by both confocal and two-photon microscopy without causing any light-induced artefacts in the electrical recordings. Graphene electrodes record high-frequency bursting activity and slow synaptic potentials that are hard to resolve by multicellular calcium imaging. This transparent electrode technology may pave the way for high spatio-temporal resolution electro-optic mapping of the dynamic neuronal activity. Monitoring neuronal activity of large populations of neurons at high-temporal and spatial resolution is important to understand neurophysiology but requires improved tools and methods. Here the authors develop a transparent and flexible electrode based on graphene that allows them to combine electrophysiological recordings with calcium imaging.
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Recent advancements in soft and nanomaterials have opened more options for flexible recording electrodes, such as conductive polymers and nanomaterial composites.
“Recent advancements in soft and nanomaterials have opened up more options for flexible recording electrodes, like conductive polymers (e.g., PEDOT)[302,312] and nanomaterial composites (metal-based, CNT, graphene)[313–317].”
From Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics (2022) · cites this paper as [317]
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- Authors
- Kuzum, D., Takano, H., Shim, E., Reed, J. C., Juul, H., Richardson, A. G., de Vries, J., Bink, H., Dichter, M. A., Lucas, T. H., Coulter, D. A., Cubukcu, E., & Litt, B.
- Affiliations
- University of Pennsylvania (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Kuzum, Duygu
- Venue
- Nature Communications
- Published
- 2014-10-20
- Volume
- 5
- Issue
- 1
- Pages
- 5259-5259
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4331185
- OpenAlex
- W4235021740
- Semantic Scholar
- c871a67c9207030c464fd1c9610c142c0325ef2e
- Cited by
- 546
- References
- 47
- Citations by year
- 2026: 20 · 2025: 38 · 2024: 40 · 2023: 53 · 2022: 46 · 2021: 67 · 2020: 53 · 2019: 63 · 2018: 61 · 2017: 61 · 2016: 32 · 2015: 12
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Citizens United for Research in Epilepsy
- Mirowski Family Foundation
- National Institutes of Health (5u24ns063930-05)
- National Institute of Neurological Disorders and Stroke (R01NS038572, 1U24 NS 63930-01A1, U24-NS063930, R01NS063039, R01NS082046)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- graphene electrodes, transparent electrodes, flexible electrodes, hippocampal slices, two-photon microscopy, confocal microscopy, neuronal activity mapping, synaptic potentials
- MeSH terms
- Animals, Brain, Calcium, Electric Stimulation, Electrocardiography, Electrodes, Electrophysiology, Female, Graphite, Hippocampus, Image Processing, Computer-Assisted, Lasers, Male, Neurons, Spectrum Analysis, Raman, Artifacts, Microscopy, Confocal, Mice, Rats, Electrophysiological Phenomena, Neuroimaging
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