Brain structural and functional alterations specific to low sleep efficiency in major depressive disorder
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BACKGROUND: Sleep disturbance is common in patients with major depressive disorder (MDD), but the exploration of its neural underpinnings is limited by subjective sleep measurement and single-modality neuroimaging analyses. METHODS: = 54; 23 men; aged 45 ± 12 years) groups. Inter-group differences in brain structure and function were examined by applying voxel-based morphometry (VBM), regional homogeneity (ReHo) and functional connectivity strength (FCS), and tract-based spatial statistics (TBSS) approaches to structural, functional, and diffusion MRI data, respectively. RESULTS: There was no significant difference in gray matter volume (GMV) between the NSE and LSE groups. Compared with the NSE group, the LSE group showed increased axial diffusivity in the left superior and posterior corona radiata, and left posterior limb and retrolenticular part of internal capsule. In addition, the LSE group exhibited decreased ReHo in the bilateral lingual gyri and right postcentral gyrus yet increased FCS in the left angular gyrus relative to the NSE group. Moreover, validation analyses revealed that these results remained after adjusting for the medication effect. CONCLUSION: Our data indicate that preserved gray matter morphology, impaired white matter integrity, and decreased local synchronization degree yet increased FCS are specific to low SE in MDD patients. These findings of disassociation between structural and functional alterations might provide insights into the neural mechanisms of sleep disturbance in depression.
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The areas of FCS decrease are prominent hubs of global and local functional connectivity, and age-related decrease could underlie performance decline in working memory and visual sustained attention.
“The areas of FCS decrease are the prominent hubs of global and local functional connectivity, and the age-related decrease could underlie the performance decline in working memory and visual sustained attention, which are the most affected cognitive functions that occur with aging [39-41].”
From Mapping neurophysiological subtypes of major depressive disorder using normative models of the functional connectome (2023) · cites this paper as [40]
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Self-citation
- Authors
- Yang, Y., Zhu, D.-M., Zhang, C., Zhang, Y., Wang, C., Zhang, B., Zhao, W., Zhu, J., & Yu, Y.
- Affiliations
- First Affiliated Hospital of Anhui Medical University (CN)
- Anhui Medical University (CN)
- Corresponding author
- Zhu, Jiajia
- Yu, Yongqiang
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-01-31
- Volume
- 14
- Pages
- 50-50
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC7005201
- OpenAlex
- W3004408022
- Cited by
- 57
- References
- 65
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 8 · 2021: 7 · 2020: 3
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81771817, 81801679, 81571308)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- major depressive disorder, sleep efficiency, sleep disorders, white matter integrity, gray matter volume, regional homogeneity, functional connectivity, corona radiata, internal capsule, angular gyrus, lingual gyrus, postcentral gyrus, diffusion MRI
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