The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Revisiting the role of acetylcholinesterase in Alzheimer’s disease: cross-talk with P-tau and β-amyloid
Open accessAbstract
A common feature in the Alzheimer's disease (AD) brain is the presence of acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and neurofibrillary tangles (NFT). Although our understanding of the relationship between AChE and the pathological features of AD is incomplete, increasing evidence suggests that both β-amyloid protein (Aβ) and abnormally hyperphosphorylated tau (P-tau) can influence AChE expression. We also review recent findings which suggest the possible role of AChE in the development of a vicious cycle of Aβ and P-tau dysregulation and discuss the limited and temporary effect of therapeutic intervention with AChE inhibitors.
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Cites
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The role of protein glycosylation in Alzheimer disease
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Ferreira, J. P. S., Albuquerque, H. M. T., Cardoso, S. M., Silva, A. M. S., & Silva, V. L. M. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113492 · Cited by 96
Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.
Sánchez, M., García-Cabrero, A., Sánchez-Elexpuru, G., Burgos, D., & Serratosa, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041092 · Cited by 68
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“146 Other proteases, such as Cathepsin B/D and Asparagine Endopeptidase (AEP), also play vital roles in disease pathology, including autophagy imbalance and pathogenic protein processing.”
Metadata
- Authors
- García-Ayllón, M.-S.
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 4
- Pages
- 22-22
- ISSN
- 1662-5099 (ISSN-L)
- OpenAlex
- W2157016321
- Cited by
- 299
- References
- 110
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- gold
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- García-Ayllón, M.-S. (2011). Revisiting the role of acetylcholinesterase in Alzheimer’s disease: cross-talk with P-tau and β-amyloid. Frontiers in Molecular Neuroscience. https://doi.org/10.3389/fnmol.2011.00022
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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