The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health
Open accessAbstract
Zinc supplementation trials in the elderly showed that the incidence of infections was decreased by approximately 66% in the zinc group. Zinc supplementation also decreased oxidative stress biomarkers and decreased inflammatory cytokines in the elderly. In our studies in the experimental model of zinc deficiency in humans, we showed that zinc deficiency per se increased the generation of IL-1β and its mRNA in human mononuclear cells following LPS stimulation. Zinc supplementation upregulated A20, a zinc transcription factor, which inhibited the activation of NF-κB, resulting in decreased generation of inflammatory cytokines. Oxidative stress and chronic inflammation are important contributing factors for several chronic diseases attributed to aging, such as atherosclerosis and related cardiac disorders, cancer, neurodegeneration, immunologic disorders and the aging process itself. Zinc is very effective in decreasing reactive oxygen species (ROS). In this review, the mechanism of zinc actions on oxidative stress and generation of inflammatory cytokines and its impact on health in humans will be presented.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism, and geophagia
Prasad, A. S., Halsted, J. A., & Nadimi, M. (1961) · The American Journal of Medicine · doi:10.1016/0002-9343(61)90137-1 · Cited by 791
Self-citationAntioxidant effect of zinc in humans
Prasad, A. S., Bao, B., Beck, F. W. J., Kucuk, O., & Sarkar, F. H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.07.007 · Cited by 520
Self-citationPrasad, A. S., Beck, F. W., Bao, B., Fitzgerald, J. T., Snell, D. C., Steinberg, J. D., & Cardozo, L. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.837 · Cited by 516
Self-citationHuman zinc deficiency, endocrine manifestations and response to treatment
SANDSTEAD, H. H., PRASAD, A. S., SCHULERT, A. R., FARID, Z., MIALE, A., BASSILLY, S., & DARBY, W. J. (1967) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/20.5.422 · Cited by 388 · cited 2×
“Participants were randomly assigned to receive daily orally one of the following: (1) antioxidants (Vitamin C 500 mg,Vitamin E 400 IU, and β-Carotene 15 mg; (2) zinc 80 mg as zinc oxide and copper 2 mg as copper oxide to prevent copper deficiency induced by therapeutic level of zinc; (3) antioxidants plus zinc, or (4)…”
MethodZinc Supplementation in Young Children with Acute Diarrhea in India
Sazawal, S., Black, R. E., Bhan, M. K., Bhandari, N., Sinha, A., & Jalla, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331304 · Cited by 383
Beck, F. W., Prasad, A. S., Kaplan, J., Fitzgerald, J. T., & Brewer, G. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.6.e1002 · Cited by 345
Self-citationSerum thymulin in human zinc deficiency
Prasad, A. S., Meftah, S., Abdallah, J., Kaplan, J., Brewer, G. J., Bach, J. F., & Dardenne, M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113717 · Cited by 335
Self-citation(2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.5.716 · Cited by 215
Prasad, A. S., Beck, F. W. J., Bao, B., Snell, D., & Fitzgerald, J. T. (2008) · The Journal of Infectious Diseases · doi:10.1086/528803 · Cited by 121
Cited by
KDOQI clinical practice guideline for nutrition in CKD: 2020 update
Ikizler, T. A., Burrowes, J. D., Byham-Gray, L. D., Campbell, K. L., Carrero, J.-J., Chan, W., Fouque, D., Friedman, A. N., Ghaddar, S., Goldstein-Fuchs, D. J., et al. (2020) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.05.006 · Cited by 1,960
IOC Consensus Statement: Dietary Supplements and the High-performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099027 · Cited by 1,004
Zinc in Wound Healing Modulation
Lin, P.-H., Sermersheim, M., Li, H., Lee, P. H. U., Steinberg, S. M., & Ma, J. (2017) · Nutrients · doi:10.3390/nu10010016 · Cited by 643
Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615
IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0020 · Cited by 540
Metadata
- Authors
- Prasad, A. S.
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2014-09-01
- Volume
- 1
- Pages
- 14-14
- ISSN
- 2296-861X (ISSN-L)
- OpenAlex
- W2063092589
- Cited by
- 489
- References
- 11
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health. https://app.cochat.ai/papers/10.3389/fnut.2014.00014
- The paper
- Prasad, A. S. (2014). Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2014.00014
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
