Zinc in Wound Healing Modulation

Lin, Pei-Hui; Sermersheim, Matthew; Li, Haichang; Lee, Peter H. U.; Steinberg, Steven M.; Ma, Jianjie

doi:10.3390/nu10010016

Cited by 643Wound Healing and TreatmentsTrace Elements in HealthPlant Micronutrient Interactions and Effects

Zinc in Wound Healing Modulation

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Lin, Pei-Hui, Sermersheim, Matthew, Li, Haichang, Lee, Peter H. U., Steinberg, Steven M., Ma, Jianjie·2017·Nutrients

DOI 10.3390/nu10010016PMC PMC5793244

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Abstract

Wound care is a major healthcare expenditure. Treatment of burns, surgical and trauma wounds, diabetic lower limb ulcers and skin wounds is a major medical challenge with current therapies largely focused on supportive care measures. Successful wound repair requires a series of tightly coordinated steps including coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodelling. Zinc is an essential trace element (micronutrient) which plays important roles in human physiology. Zinc is a cofactor for many metalloenzymes required for cell membrane repair, cell proliferation, growth and immune system function. The pathological effects of zinc deficiency include the occurrence of skin lesions, growth retardation, impaired immune function and compromised would healing. Here, we discuss investigations on the cellular and molecular mechanisms of zinc in modulating the wound healing process. Knowledge gained from this body of research will help to translate these findings into future clinical management of wound healing.

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The oral and/or topical administration of zinc has long been used for its effect on skin regeneration and healing.
“The oral and/or topical administration of Zn has long been used for its effect on skin regeneration and healing [99,109].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [109]

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The role of antioxidant micronutrients in the rate of recovery of burn patients: a systematic review
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The Estrogen-responsive B Box Protein
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Tripartite Motif 16 Inhibits the Migration and Invasion in Ovarian Cancer Cells
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TRIM72 modulates caveolar endocytosis in repair of lung cells
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MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress
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Zinc-mediated feedback at the synaptic terminals of vertebrate photoreceptors
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Nutrition
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Cellular zinc metabolism and zinc signaling: From biological functions to diseases and therapeutic targets
Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420 · see citing works
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Authors: Lin, P.-H., Sermersheim, M., Li, H., Lee, P. H. U., Steinberg, S. M., & Ma, J.
Affiliations: The Ohio State University Wexner Medical Center (US)
Corresponding author: Lin, Pei-Hui
Ma, Jianjie
ORCID: Lin, Pei-Hui
Sermersheim, Matthew
Li, Haichang
Lee, Peter H. U.
Ma, Jianjie
Venue: Nutrients
Publisher: MDPI AG
Published: 2017-12-24
Volume: 10
Issue: 1
Pages: 16
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu10010016
PMC: PMC5793244
OpenAlex: W2779215932
Cited by: 643
References: 176
Citations by year: 2026: 85 · 2025: 139 · 2024: 104 · 2023: 76 · 2022: 77 · 2021: 63 · 2020: 63 · 2019: 30 · 2018: 6
FWCI: 3.68
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: NIH (AR061385, AG056919, AR070752)
Topics: Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Keywords: zinc, wound healing, zinc deficiency, trace elements, angiogenesis, inflammation, extracellular matrix remodeling, diabetic ulcers, burns, skin wounds, zinc cofactor, cell proliferation
MeSH terms: Tripartite Motif Proteins, Animals, Antioxidants, Extracellular Matrix, Humans, Time Factors, Wound Healing, Zinc, Signal Transduction, Oxidative Stress

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Zinc in Wound Healing Modulation

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