The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health
Open accessAbstract
Zinc supplementation trials in the elderly showed that the incidence of infections was decreased by approximately 66% in the zinc group. Zinc supplementation also decreased oxidative stress biomarkers and decreased inflammatory cytokines in the elderly. In our studies in the experimental model of zinc deficiency in humans, we showed that zinc deficiency per se increased the generation of IL-1β and its mRNA in human mononuclear cells following LPS stimulation. Zinc supplementation upregulated A20, a zinc transcription factor, which inhibited the activation of NF-κB, resulting in decreased generation of inflammatory cytokines. Oxidative stress and chronic inflammation are important contributing factors for several chronic diseases attributed to aging, such as atherosclerosis and related cardiac disorders, cancer, neurodegeneration, immunologic disorders and the aging process itself. Zinc is very effective in decreasing reactive oxygen species (ROS). In this review, the mechanism of zinc actions on oxidative stress and generation of inflammatory cytokines and its impact on health in humans will be presented.
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Cites
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Self-citationAntioxidant effect of zinc in humans
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Self-citationHuman zinc deficiency, endocrine manifestations and response to treatment
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“Participants were randomly assigned to receive daily orally one of the following: (1) antioxidants (Vitamin C 500 mg,Vitamin E 400 IU, and β-Carotene 15 mg; (2) zinc 80 mg as zinc oxide and copper 2 mg as copper oxide to prevent copper deficiency induced by therapeutic level of zinc; (3) antioxidants plus zinc, or (4)…”
MethodZinc Supplementation in Young Children with Acute Diarrhea in India
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Self-citationSerum thymulin in human zinc deficiency
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Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099027 · Cited by 1,004
Zinc in Wound Healing Modulation
Lin, P.-H., Sermersheim, M., Li, H., Lee, P. H. U., Steinberg, S. M., & Ma, J. (2017) · Nutrients · doi:10.3390/nu10010016 · Cited by 643
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IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0020 · Cited by 540
Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems
Lee, S. R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9156285 · Cited by 458
van Dronkelaar, C., van Velzen, A., Abdelrazek, M., van der Steen, A., Weijs, P. J. M., & Tieland, M. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.05.026 · Cited by 279
Chen, L.-L., Fan, Y.-G., Zhao, L.-X., Zhang, Q., & Wang, Z.-Y. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106301 · Cited by 200
Zinc deficiency as a mediator of toxic effects of alcohol abuse
Skalny, A. V., Skalnaya, M. G., Grabeklis, A. R., Skalnaya, A. A., & Tinkov, A. A. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1584-y · Cited by 60
Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases
Rodella, U., Honisch, C., Gatto, C., Ruzza, P., & D’Amato Tóthová, J. (2023) · Nutrients · doi:10.3390/nu15102283 · Cited by 59
Zinc homeostasis and redox alterations in obesity
Franco, C., & Canzoniero, L. M. T. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1273177 · Cited by 31
Wang, H.-L., Liu, L.-L., Tan, Z.-Y., Zhou, Y., Zhang, J., Zhai, L., Xie, Q., & Liu, R.-H. (2025) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2025.104992 · Cited by 10
Metadata
- Authors
- Prasad, A. S.
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2014-09-01
- Volume
- 1
- Pages
- 14-14
- ISSN
- 2296-861X (ISSN-L)
- OpenAlex
- W2063092589
- Cited by
- 489
- References
- 11
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- gold
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