The DOI matches its Crossref record; 261 of the 262 references it cites were found in a registry or an index.
Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies
Open accessAbstract
Metabolic syndrome (MetS) is a multifaceted condition that increases the possibility of developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension, dyslipidemia, hyperglycemia, endothelial dysfunction, and platelet hyperactivity. There is a concerning rise in the occurrence and frequency of MetS globally. The rising incidence and severity of MetS need a proactive, multipronged strategy for identifying and treating those affected. For many MetS patients, achieving recommended goals for healthy fat intake, blood pressure control, and blood glucose management may require a combination of medicine therapy, lifestyles, nutraceuticals, and others. However, it is essential to note that lifestyle modification should be the first-line therapy for MetS. In addition, MetS requires pharmacological, nutraceutical, or other interventions. This review aimed to bring together the etiology, molecular mechanisms, and dietary strategies to combat hypertension, endothelial dysfunction, and platelet dysfunction in individuals with MetS.
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“Hyperglycaemia, insulin resistance and chronic inflammation promote the formation of ROS, which scavenge NO and impair eNOS activity.”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [205]
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Metadata
- Authors
- Das, D., Shruthi, N. R., Banerjee, A., Jothimani, G., Duttaroy, A. K., & Pathak, S.
- Affiliations
- Chettinad Academy of Research and Education (IN)
- University of Oslo (NO)
- Corresponding author
- Duttaroy, Asim K.
- Pathak, Surajit
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2023-08-08
- Volume
- 10
- Pages
- 1221438-1221438
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC10442661
- OpenAlex
- W4385663817
- Cited by
- 90
- References
- 262
- Citations by year
- 2026: 30 · 2025: 39 · 2024: 21
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Funders
- Universitetet i Oslo
- Chettinad Academy of Research and Education
- Medisinske fakultet, Universitetet i Oslo
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- metabolic syndrome, endothelial dysfunction, platelet hyperreactivity, hypertension, obesity, dyslipidemia, hyperglycemia, atherosclerotic cardiovascular disease, molecular mechanisms, lifestyle modification, nutraceuticals, nutritional strategies, blood pressure control, glucose management
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