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Cited by 208Mitochondrial Function and PathologyCell death mechanisms and regulationAutophagy in Disease and Therapy

The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death

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Bonora, Massimo, Pinton, Paolo·2014·Frontiers in Oncology
DOI 10.3389/fonc.2014.00302PMC PMC4235083
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Abstract

Since its discovery in the 1970s, the mitochondrial permeability transition (MPT) has been proposed to be a strategic regulator of cell death. Intense research efforts have focused on elucidating the molecular components of the MPT because this knowledge may help to better understand and treat various pathologies ranging from neurodegenerative and cardiac diseases to cancer. In the case of cancer, several studies have revealed alterations in the activity of the mitochondrial permeability transition pore (mPTP) and have determined its regulatory mechanism; these studies have also suggested that suppression of the activity of the mPTP, rather than its inactivation, commonly occurs in solid neoplasms. This review focuses on the most recent advances in understanding mPTP regulation in cancer and highlights the ability of the mPTP to impede the mechanisms of cell death.

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Cited by

Sorted by citations

Authors
Bonora, M., & Pinton, P.
Affiliations
University of Ferrara (IT)
Corresponding author
Pinton, Paolo
ORCID
Venue
Frontiers in Oncology
Publisher
Frontiers Media SA
Published
2014-11-17
Volume
4
Pages
302-302
ISSN
2234-943X (ISSN-L)
DOI
10.3389/fonc.2014.00302
PMC
PMC4235083
OpenAlex
W2117407594
Cited by
208
References
5
Citations by year
2026: 13 · 2025: 15 · 2024: 26 · 2023: 21 · 2022: 20 · 2021: 22 · 2020: 22 · 2019: 14 · 2018: 11 · 2017: 15 · 2016: 19 · 2015: 10
FWCI
1.38
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Oncology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
Funders
  • Ministero dell’Istruzione, dell’Università e della Ricerca
  • Associazione Italiana per la Ricerca sul Cancro (GGP11139B)
  • Università degli Studi di Ferrara (GGP11139B)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial permeability transition pore, mitochondrial permeability transition, cancer, cell death, solid tumors, apoptosis, neurodegenerative diseases, heart disease

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