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Cited by 359

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

21-Gene Recurrence Score Assay and Outcomes of Adjuvant Radiotherapy in Elderly Women With Early-Stage Breast Cancer After Breast-Conserving Surgery

Open access
Wu, San-Gang, Zhang, Wen-Wen, Wang, Jun, Dong, Yong, Sun, Jia-Yuan, Chen, Yong-Xiong, He, Zhen-Yu·2019·Frontiers in Oncology
DOI 10.3389/fonc.2019.00001
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Abstract

Introduction: To assess the role of the 21-gene recurrence score (RS) assay on decision-making of postoperative radiotherapy (RT) following breast-conserving surgery (BCS) in elderly women with early-stage breast cancer. Methods: The 21-gene RS for elderly (≥65 years) women with stage T1–2N0M0 estrogen receptor-positive breast cancer who underwent BCS from 2004 to 2015 was obtained from the Surveillance, Epidemiology, and End Results program. We estimated the association of 21-gene RS and adjuvant RT related to breast cancer-specific survival (BCSS) using propensity score matching (PSM). Results: We identified 18,456 patients, of which 15,326 (83.0%) received postoperative RT. Of identified patients, 58.9%, 34.0%, and 7.1% of patients had a low-, intermediate-, and high-risk RS, respectively. Receipt of postoperative RT was not related to the year of diagnosis according to the 21-gene RS groups. Multivariate analysis suggested that receipt of postoperative RT was an independent predictor of better BCSS before (hazard ratio [HR] 0.587, 95% confidence interval [CI] 0.426–0.809, P = 0.001) and after (HR 0.613, 95%CI 0.390–0.963, P = 0.034) PSM. However, subgroups analyses indicated that receipt of postoperative RT was related to better BCSS in women with intermediate-risk RS before (HR 0.467, 95%CI 0.283–0.772, P = 0.003) and after (HR 0.389, 95%CI 0.179–0.846, P = 0.017) PSM, but not in women with low- and high-risk RS groups before and after PSM. Conclusions: Although causation cannot be implied, adjuvant RT in elderly women was associated with a greater effect size in patients with an intermediate-risk RS.

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Metadata

Authors
Wu, S.-G., Zhang, W.-W., Wang, J., Dong, Y., Sun, J.-Y., Chen, Y.-X., & He, Z.-Y.
Venue
Frontiers in Oncology
Publisher
Frontiers Media SA
Published
2019-01-29
Volume
9
Pages
1-1
ISSN
2234-943X (ISSN-L)
DOI
10.3389/fonc.2019.00001
OpenAlex
W2911866893
Cited by
359
References
27
FWCI
23.08
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: 21-Gene Recurrence Score Assay and Outcomes of Adjuvant Radiotherapy in Elderly Women With Early-Stage Breast Cancer After Breast-Conserving Surgery. https://app.cochat.ai/papers/10.3389/fonc.2019.00001
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Wu, S.-G., Zhang, W.-W., Wang, J., Dong, Y., Sun, J.-Y., Chen, Y.-X., & He, Z.-Y. (2019). 21-Gene Recurrence Score Assay and Outcomes of Adjuvant Radiotherapy in Elderly Women With Early-Stage Breast Cancer After Breast-Conserving Surgery. Frontiers in Oncology. https://doi.org/10.3389/fonc.2019.00001

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