Urine Output Assessment in Acute Kidney Injury: The Cheapest and Most Impactful Biomarker
Open accessAbstract
Acute kidney injury (AKI) is independently associated with morbidity and mortality in critically ill neonates, children, adolescents, and young adults. AKI occurs commonly in this population, and the vast majority of published studies utilize only a serum creatinine based criteria for AKI diagnosis and staging. While urine output criteria have been a part of all AKI systematic and multidimensional AKI definitions for the past 15 years, oliguria based on these definitions is difficult to extract from the electronic health record. This manuscript reviews the published data regarding the impact of oliguria on patient outcomes, and the contribution of oliguria to % fluid overload and resultant changes in serum creatinine based epidemiology. The aim of this manuscript is to demonstrate that oliguria is an incredibly valuable biomarker for the management of patients with, or at-risk for, AKI.
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Urine output is regarded as a sensitive and early marker of renal dysfunction.
“Urine output is regarded as a sensitive and early marker of renal dysfunction [20].”
From Trends and Challenges in Noninvasive Hemodynamic Monitoring of Neonates Following Cardiac Surgery: A Narrative Review (2025) · cites this paper as [20]
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Effect of urinary extracts from salt-loaded man on urinary sodium excretion by the rat
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Nedelcu, C., Ionescu, N. S., Bizubac, A. M., Filip, C., & Cirstoveanu, C. (2025) · Life · doi:10.3390/life15101621 · Cited by 2 · see citing works
“Urine output is regarded as a sensitive and early marker of renal dysfunction [20].”
- Authors
- Goldstein, S. L.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Goldstein, Stuart L.
- ORCID
- Goldstein, Stuart L.
- Venue
- Frontiers in Pediatrics
- Publisher
- Frontiers Media SA
- Published
- 2020-01-21
- Volume
- 7
- Pages
- 565-565
- ISSN
- 2296-2360 (ISSN-L)
- PMC
- PMC6985265
- OpenAlex
- W3002011214
- Cited by
- 41
- References
- 13
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 11 · 2023: 4 · 2022: 7 · 2021: 9
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pediatrics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Keywords
- acute kidney injury, urine output, oliguria, biomarkers, fluid overload, serum creatinine, AKI staging, pediatric patients, critically ill children, patient outcomes
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