The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Free fatty acid receptors as therapeutic targets for the treatment of diabetes
Open accessAbstract
Nutrition regulates energy balance; however, dysfunction of energy balance can cause metabolic disorders, such as obesity and diabetes. Fatty acids are an essential energy source and signaling molecules that regulate various cellular processes and physiological functions. Recently, several orphan G protein-coupled receptors were identified as free fatty acid receptors (FFARs). GPR40/FFAR1 and GPR120/FFAR4 are activated by medium- and/or long-chain fatty acids, whereas GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain fatty acids. FFARs are regarded as targets for novel drugs to treat metabolic disorders, such as obesity and type 2 diabetes, because recent studies have showed that these receptors are involved in the energy metabolism in various tissues, including adipose, intestinal, and immune tissue. In this review, we summarize physiological roles of the FFARs, provide a comprehensive overview of energy regulation by FFARs, and discuss new prospects for treatment of metabolic disorders.
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Cites
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Cited by
Free Fatty Acid Receptors in Health and Disease
Kimura, I., Ichimura, A., Ohue-Kitano, R., & Igarashi, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00041.2018 · Cited by 1,018
Self-citationMiyamoto, J., Igarashi, M., Watanabe, K., Karaki, S.-I., Mukouyama, H., Kishino, S., Li, X., Ichimura, A., Irie, J., Sugimoto, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11978-0 · Cited by 392
Self-citationOmega-3 fatty acids in obesity and metabolic syndrome: A mechanistic update
Albracht-Schulte, K., Kalupahana, N. S., Ramalingam, L., Wang, S., Rahman, S. M., Robert-McComb, J., & Moustaid-Moussa, N. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.012 · Cited by 355
“Appetite suppression could also be mediated through FFAR4 (GPR 120).”
BackgroundInfluentialω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer
D’Angelo, S., Motti, M. L., & Meccariello, R. (2020) · Nutrients · doi:10.3390/nu12092751 · Cited by 250
Waddell, I. S., & Orfila, C. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2061909 · Cited by 211
Metadata
- Authors
- Ichimura, A., Hasegawa, S., Kasubuchi, M., & Kimura, I.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2014-11-06
- Volume
- 5
- Pages
- 236-236
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W2033337344
- Cited by
- 170
- References
- 9
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ichimura, A., Hasegawa, S., Kasubuchi, M., & Kimura, I. (2014). Free fatty acid receptors as therapeutic targets for the treatment of diabetes. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2014.00236
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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