Cited by 392Gut microbiota and healthFatty Acid Research and HealthAdipokines, Inflammation, and Metabolic Diseases

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

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Miyamoto, Junki, Igarashi, Miki, Watanabe, Keita, Karaki, Shin-ichiro, Mukouyama, Hiromi, Kishino, Shigenobu, Li, Xuan, Ichimura, Atsuhiko, Irie, Junichiro, Sugimoto, Yukihiko, Mizutani, Tetsuya, Sugawara, Tatsuya, Miki, Takashi, Ogawa, Jun, Drucker, Daniel J., Arita, Makoto, Itoh, Hiroshi, Kimura, Ikuo·2019·Nature Communications

Abstract

Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and related diseases. Although gut-microbiota-related metabolic pathways of dietary PUFAs were recently elucidated, the effects on host physiological function remain unclear. Here, we demonstrate that gut microbiota confers host resistance to high-fat diet (HFD)-induced obesity by modulating dietary PUFAs metabolism. Supplementation of 10-hydroxy- cis -12-octadecenoic acid (HYA), an initial linoleic acid-related gut-microbial metabolite, attenuates HFD-induced obesity in mice without eliciting arachidonic acid-mediated adipose inflammation and by improving metabolic condition via free fatty acid receptors. Moreover, Lactobacillus -colonized mice show similar effects with elevated HYA levels. Our findings illustrate the interplay between gut microbiota and host energy metabolism via the metabolites of dietary omega-6-FAs thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.

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Authors
Miyamoto, J., Igarashi, M., Watanabe, K., Karaki, S.-I., Mukouyama, H., Kishino, S., Li, X., Ichimura, A., Irie, J., Sugimoto, Y., Mizutani, T., Sugawara, T., Miki, T., Ogawa, J., Drucker, D. J., Arita, M., Itoh, H., & Kimura, I.
Affiliations
  • Japan Agency for Medical Research and Development (JP)
  • Tokyo University of Agriculture and Technology (JP)
  • Shizuoka University (JP)
  • Kyoto University (JP)
  • Keio University (JP)
  • Chiba University (JP)
  • Mount Sinai Hospital (CA)
Corresponding author
Kimura, Ikuo
Venue
Nature Communications
Published
2019-09-05
Volume
10
Issue
1
Pages
4007-4007
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2971602650
Cited by
392
References
40
Citations by year
2026: 46 · 2025: 60 · 2024: 65 · 2023: 62 · 2022: 64 · 2021: 51 · 2020: 40 · 2019: 1
FWCI
12.91
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • MEXT | Japan Society for the Promotion of Science (JP15H05344, JP16H01355)
  • Japan Agency for Medical Research and Development (JP18gm1010007)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
gut microbiota, obesity, omega-6 fatty acids, high-fat diet, linoleic acid metabolites, Lactobacillus, free fatty acid receptors, adipose tissue inflammation, arachidonic acid, energy metabolism, metabolic disorders
MeSH terms
Gastrointestinal Microbiome, Adipose Tissue, Animals, Cell Line, Dietary Fats, Unsaturated, Energy Metabolism, Fatty Acids, Unsaturated, Humans, Inflammation, Lactobacillus, Metabolic Diseases, Mice, Inbred C57BL, Obesity, Oleic Acids, Dietary Supplements, Linoleic Acid, Models, Animal, Fatty Acids, Omega-6, Mice, Diet, High-Fat, Diet, Western

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