The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
Open accessAbstract
The amyloid β peptide (Aβ) is a critical initiator that triggers the progression of Alzheimer's Disease (AD) via accumulation and aggregation, of which the process may be caused by Aβ overproduction or perturbation clearance. Aβ is generated from amyloid precursor protein through sequential cleavage of β- and γ-secretases while Aβ removal is dependent on the proteolysis and lysosome degradation system. Here, we overviewed the biogenesis and toxicity of Aβ as well as the regulation of Aβ production and clearance. Moreover, we also summarized the animal models correlated with Aβ that are essential in AD research. In addition, we discussed current immunotherapeutic approaches targeting Aβ to give some clues for exploring the more potentially efficient drugs for treatment of AD.
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
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“…APP carrying both the Swedish and Indiana mutation under the control of the murine Thy 1.2 promoter. of AD, the majority are overexpression transgenic lines (see the summary in Table 1C; Oakley et al., 2006; Elder et al., 2010; Do Carmo and Cuello, 2013; Lublin and Link, 2013; Lim et al., 2016).”
BackgroundInfluentialPathways towards and Away from Alzheimer’s Disease
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“Therefore, Aβ is predicted to be the most potentially efficient target of the drug therapies (Karran et al., 2011).”
BackgroundTwo Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960
Cited by
Fricker, M., Tolkovsky, A. M., Borutaite, V., Coleman, M., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,108
Biological Activities of Stilbenoids
Akinwumi, B., Bordun, K.-A., & Anderson, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030792 · Cited by 373
Li, H., Liu, C.-C., Zheng, H., & Huang, T. Y. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0139-3 · Cited by 103
Naeem, A., Prakash, R., Kumari, N., Ali Khan, M., Quaiyoom Khan, A., Uddin, S., Verma, S., AB Robertson, A., Boltze, J., & Shadab Raza, S. (2024) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2023.11.031 · Cited by 96
Selective Secretase Targeting for Alzheimer’s Disease Therapy
Miranda, A., Montiel, E., Ulrich, H., & Paz, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201027 · Cited by 66
Metadata
- Authors
- Sun, X., Chen, W.-D., & Wang, Y.-D.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2015-09-30
- Volume
- 6
- Pages
- 221-221
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W1804923980
- Cited by
- 323
- References
- 34
- FWCI
- 14.63
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sun, X., Chen, W.-D., & Wang, Y.-D. (2015). β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2015.00221
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
