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A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor

Lin, Longfei, Li, Hui, Lin, Hongmei, Zhang, Miao, Qu, Changhai, Yan, Lei, Yin, Xingbin, Ni, Jian·2017·Frontiers in Pharmacology
DOI 10.3389/fphar.2017.00349PMC PMC5476691
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  • Results obtained with PM, harvested from various regions of China and assessed for its hepatotoxic potential, showed that liver toxicity was obviously different among the various areas of harvest, and the most toxic PM was from the Sichuan Province.

    “These results showed that liver toxicity was obviously different among the various areas of harvest, and the most toxic PM was from the Sichuan Province.”

    From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [88]

  • Emodin was not considered the main hepatotoxin anymore, as opposed to previous studies.

    “It is noteworthy that emodin was not considered the main hepatotoxin anymore, as opposed to previous studies.88–90”

    From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [88]

  • Preference is now given to both tetrahydroxystilbene-O-(galloyl)-hex and emodin-O-hex-sulfate as the primary offending agents.

    “Preference is now given to both tetrahydroxystilbene-O-(galloyl)-hex and emodin-O-hex-sulfate as the primary offending agents.88”

    From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [88]

  • HILI-specific risk factors include quality of products, identical names but different substances, counterfeit drug misuse, mixing or adulteration, environmental contaminants, unreasonable or incompatible formulation, and irrational use of HDS.

    “However, the following HILI-specific risk factors may cause liver injury [126-133]: (1) quality of products: different places of origin and improper preparation may cause differences in components, thereby increasing the risk of hepatotoxicity; (2) identical names but different substances, counterfeit drug misuse, mixing, or adulteration; (3) environmental contaminants, such as pesticide residues,”

    From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [126]

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Cited by

Sorted by citations

Metadata

Authors
Lin, L., Li, H., Lin, H., Zhang, M., Qu, C., Yan, L., Yin, X., & Ni, J.
Venue
Frontiers in Pharmacology
Publisher
Frontiers Media SA
Published
2017-06-20
Volume
8
ISSN
1663-9812
DOI
10.3389/fphar.2017.00349
PMC
PMC5476691
Cited by
20
References
0
Funders
National Natural Science Foundation of China (81673609)

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