Cited by 116Ginkgo biloba and Cashew ApplicationsMedicinal Plants and NeuroprotectionAlzheimer's disease research and treatments

An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients

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Liu, Haolong, Ye, Min, Guo, Hongzhu·2020·Frontiers in Pharmacology

Abstract

Alzheimer’s disease (AD) is a common neurodegenerative disease, mainly manifested by cognitive dysfunction. It seriously reduces the quality of life, and there is no ideal treatment strategy in clinical practice. Clinical studies on the treatment of AD with Ginkgo biloba L. leaf extract (EGb) have been reported since 1980s, and many clinical studies have been carried out during the following 30 years. However, the benefits of EGb on the treatment of AD are still controversial. In this review, we collected the clinical trial reports of EGb on cognitive function from Pubmed, Elsevier, Europe PMC and other data base since the 1980s. Through analysis and comparison, we consider that EGb may be able to improve the cognitive function in patients suffered from mild dementia during long-term administration (more than 24 weeks) and appropriate dosage (240 mg per day). The main evidences and existing problems of the negative and positive experimental results were summarized.

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Authors
Liu, H., Ye, M., & Guo, H.
Affiliations
  • Peking University (CN)
  • National Medical Products Administration (CN)
Corresponding author
  • Ye, Min
  • Guo, Hongzhu
Venue
Frontiers in Pharmacology
Published
2020-02-21
Volume
10
Pages
1688-1688
ISSN
1663-9812 (ISSN-L)
OpenAlex
W3006905403
Cited by
116
References
61
Citations by year
2026: 8 · 2025: 16 · 2024: 16 · 2023: 19 · 2022: 20 · 2021: 27 · 2020: 10
FWCI
3.88
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Beijing Postdoctoral Science Foundation
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Ginkgo biloba extract, EGB, Alzheimer's disease, cognitive function, mild dementia, long-term administration, dosage, randomized controlled trials, neurodegenerative disease treatment

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