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Insights into bone morphogenetic proteins in cardiovascular diseases
Open accessAbstract
Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progressed, BMPs have been found to be closely related to cardiovascular diseases, especially atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT). In this review, we summarized the potential roles and related mechanisms of the BMP family in the cardiovascular system and focused on atherosclerosis and PAH.
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“BMP-2 has known roles in development [36], on tumorigenesis, [37] and in various body tissues [38–40].”
From Keratin Scaffold Formulation Impacts rhBMP-2 Biodistribution and Bone Regeneration in a Rat Femur Defect Model (2025) · cites this paper as [40]
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Metadata
- Authors
- Ye, D., Liu, Y., Pan, H., Feng, Y., Lu, X., Gan, L., Wan, J., & Ye, J.
- Affiliations
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Corresponding author
- Wan, Jun
- Ye, Jing
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2023-02-23
- Volume
- 14
- Pages
- 1125642-1125642
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC9996008
- OpenAlex
- W4321597359
- Cited by
- 37
- References
- 258
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 12
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82070436)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- bone morphogenetic proteins, cardiovascular disease, atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension, hereditary hemorrhagic telangiectasia, TGF-beta superfamily, vascular remodeling
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