The DOI matches its Crossref record; 256 of the 258 references it cites were found in a registry or an index.
Insights into bone morphogenetic proteins in cardiovascular diseases
Open accessAbstract
Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progressed, BMPs have been found to be closely related to cardiovascular diseases, especially atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT). In this review, we summarized the potential roles and related mechanisms of the BMP family in the cardiovascular system and focused on atherosclerosis and PAH.
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“BMP-2 has known roles in development [36], on tumorigenesis, [37] and in various body tissues [38–40].”
From Keratin Scaffold Formulation Impacts rhBMP-2 Biodistribution and Bone Regeneration in a Rat Femur Defect Model (2025) · cites this paper as [40]
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Cites
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A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.Preprint
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Ortega, M. A., León-Oliva, D. D., Gimeno, M. J., Boaru, D. L., Fraile‐Μartinez, O., Montero, C. G., de Castro, A. V., Barrena-Blázquez, S., López-González, L., Amor, S., et al. (2024) · Biomolecules · doi:10.3390/biom14030275 · Cited by 51
Winters, J., Kawczynski, M. J., Gilbers, M. D., Isaacs, A. J., Zeemering, S., Bidar, E., Maesen, B. A. E., Rienstra, M., Gelder, I. C. V., Verheule, S., et al. (2024) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2024.03.003 · Cited by 26
Chen, H., Peng, C.-Y., Fang, F., Li, Y., Liu, X., Hu, Y., Wang, G., Liu, X., & Shen, Y. (2025) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2025.100114 · Cited by 15
Pericardial Fluid of Patients With Coronary Artery Disease Can Drive Fibrosis Via TGF-Beta Pathway
Hassanabad, A. F., Belke, D. D., Gordon, P. M. K., Teng, G., Dundas, J. A., Zarzycki, A. N., Turnbull, J., Deniset, J., & Fedak, P. W. M. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.06.007 · Cited by 10
Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure
Peterson, T. E., Hahn, V. S., Moaddel, R., Zhu, M., Haberlen, S., Palella, F. J., Plankey, M. W., Bader, J. S., Lima, J. A. C., Gerszten, R. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-55911-0 · Cited by 10
Metadata
- Authors
- Ye, D., Liu, Y., Pan, H., Feng, Y., Lu, X., Gan, L., Wan, J., & Ye, J.
- Affiliations
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Corresponding author
- Wan, Jun
- Ye, Jing
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2023-02-23
- Volume
- 14
- Pages
- 1125642-1125642
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC9996008
- OpenAlex
- W4321597359
- Cited by
- 37
- References
- 258
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 12
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82070436)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- bone morphogenetic proteins, cardiovascular disease, atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension, hereditary hemorrhagic telangiectasia, TGF-beta superfamily, vascular remodeling
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