Insights into bone morphogenetic proteins in cardiovascular diseases

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Untitled work

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Signaling cross-talk between TGF-β/BMP and other pathways

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BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.Preprint

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Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

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Bone morphogenetic protein receptors and signal transduction

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Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

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Smooth muscle cell phenotypic switching in atherosclerosis

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Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

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Defective Angiogenesis in Mice Lacking Endoglin

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The Global Burden of Cardiovascular Diseases and Risks

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Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.Preprint

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Medial vascular calcification revisited: review and perspectives

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Pulmonary Arterial Hypertension

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Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

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Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

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Diagnosis and Treatment of Pulmonary Arterial Hypertension

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Histone deacetylases, transcriptional control, and cancer

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Sotatercept for the Treatment of Pulmonary Arterial Hypertension

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Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis

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Lack of the bone morphogenetic protein BMP6 induces massive iron overload

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Bone Morphogenetic ProteinsPreprint

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Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

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Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

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Signal transduction by bone morphogenetic proteins

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BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

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Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

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BMP10 is essential for maintaining cardiac growth during murine cardiogenesis

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Arteriovenous malformations in mice lacking activin receptor-like kinase-1

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Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

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Anti-Inflammatory Mechanisms in the Vascular Wall

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BMP Type II Receptor Is Required for Gastrulation and Early Development of Mouse Embryos

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Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter

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An essential role of Bmp4 in the atrioventricular septation of the mouse heart

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Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

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TGF-β Signaling in Control of Cardiovascular Function

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ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

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Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.

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Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells

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Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models

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BMP signalling: agony and antagony in the family

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Alterations of β-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-β1

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BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells

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Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

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Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3

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Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis

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Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle

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ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

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Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

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Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation

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FGF2 Sustains NANOG and Switches the Outcome of BMP4-Induced Human Embryonic Stem Cell Differentiation

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RANKL Increases Vascular Smooth Muscle Cell Calcification Through a RANK-BMP4–Dependent Pathway

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Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction

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Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells

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Targeting BMP signalling in cardiovascular disease and anaemia

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Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects

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Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein‐6

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Structural insights into BMP receptors: Specificity, activation and inhibition

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ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

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BMP-7 Is an Efficacious Treatment of Vascular Calcification in a Murine Model of Atherosclerosis and Chronic Renal Failure

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Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells

Yu, P. B., Beppu, H., Kawai, N., Li, E., & Bloch, K. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502825200 · Cited by 213

Role of bone morphogenetic proteins in cardiac differentiation

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Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

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BMP signaling is required for septation of the outflow tract of the mammalian heart

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Association between Initial Treatment Strategy and Long-Term Survival in Pulmonary Arterial Hypertension

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Pulmonary Arterial Hypertension: Diagnosis, Treatment, and Novel Advances

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BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia

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Targeting transforming growth factor-β receptors in pulmonary hypertension

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High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells

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Smad4 and β-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2

Hussein, S. M. I., Duff, E. K., & Sirard, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305472200 · Cited by 198

A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2

Srinivasan, S. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg050 · Cited by 196

Circulating Growth Differentiation Factor 11/8 Levels Decline With Age

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Activation of Vascular Bone Morphogenetic Protein Signaling in Diabetes Mellitus

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GDF11 Does Not Rescue Aging-Related Pathological Hypertrophy

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Postinfarction Gene Therapy Against Transforming Growth Factor-β Signal Modulates Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure

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Generation of the epicardial lineage from human pluripotent stem cells

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Syndromic and non‐syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

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Focal Arterial Inflammation Precedes Subsequent Calcification in the Same Location

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BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF

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BMP signaling in vascular biology and dysfunction

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Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

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Bone Morphogenetic Proteins in Vascular Homeostasis and DiseasePreprint

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Anterior Endomesoderm Specification inXenopusby Wnt/β-catenin and TGF-β Signalling Pathways

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Involvement of Endogenous Bone Morphogenetic Protein (BMP) 2 and BMP6 in Bone Formation

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Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart

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Distinct Patterns of Transforming Growth Factor-β Isoform and Receptor Expression in Human Atherosclerotic Lesions

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Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats

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Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

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Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation

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Smads, Tak1, and Their Common Target Atf-2 Play a Critical Role in Cardiomyocyte Differentiation

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BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling

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Bone Morphogenic Protein-4 Impairs Endothelial Function Through Oxidative Stress–Dependent Cyclooxygenase-2 Upregulation

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Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

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Bone Morphogenetic Protein-4 Mediates Cardiac Hypertrophy, Apoptosis, and Fibrosis in Experimentally Pathological Cardiac Hypertrophy

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Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

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CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy

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SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2

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Bone Morphogenic Protein-4 Induces Hypertension in Mice

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Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

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Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

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GDF11 Protects against Endothelial Injury and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice

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Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

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Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation

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Anti-Inflammatory and Antiatherogenic Role of BMP Receptor II in Endothelial Cells

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Opposing roles and potential antagonistic mechanism between TGF-β and BMP pathways: Implications for cancer progression

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Bone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells

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Heat Shock Protein 70 Enhances Vascular Bone Morphogenetic Protein-4 Signaling by Binding Matrix Gla Protein

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Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure

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BMP-7 Attenuates Inflammation-Induced Pyroptosis and Improves Cardiac Repair in Diabetic Cardiomyopathy

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BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance

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Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10

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Regulation of Notch signaling genes during BMP2-induced differentiation of osteoblast precursor cells

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Untitled work

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BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State

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Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature

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Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients

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Transforming Growth Factor-β Blockade Down-Regulates the Renin-Angiotensin System and Modifies Cardiac Remodeling after Myocardial Infarction

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BMP ‐9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK 1 mediated pathway

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BMP-7 Treatment Increases M2 Macrophage Differentiation and Reduces Inflammation and Plaque Formation in Apo E-/- Mice

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Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling

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KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling

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Impact of Glutathione Peroxidase-1 Deficiency on Macrophage Foam Cell Formation and Proliferation: Implications for Atherogenesis

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Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2

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Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling

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Transforming Growth Factor-β1 Represses Bone Morphogenetic Protein–Mediated Smad Signaling in Pulmonary Artery Smooth Muscle Cells via Smad3

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Identification and validation of a novel pathogenic variant in GDF2 ( BMP9 ) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations

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The BMP-7–Smad1/5/8 Pathway Promotes Kidney Repair After Obstruction Induced Renal Injury

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BMP-7 attenuates adverse cardiac remodeling mediated through M2 macrophages in prediabetic cardiomyopathy

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SM22α-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis

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Comparison of American and European Guidelines for Primary Prevention of Cardiovascular Disease

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BMP-6 accelerates both chondrogenesis and mineral maturation in differentiating chick limb-bud mesenchymal cell cultures

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BMP-7 attenuated silica-induced pulmonary fibrosis through modulation of the balance between TGF-β/Smad and BMP-7/Smad signaling pathway

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Dysregulation of interaction between LOXhigh fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection

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BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways

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Bone morphogenetic protein-7 inhibits silica-induced pulmonary fibrosis in rats

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BMP-2/7 heterodimer strongly induces bone regeneration in the absence of increased soft tissue inflammation

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Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development

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Bmp signaling repressesVegfato promote outflow tract cushion development

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Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX‐2 Pathway in Rats with Hypertension

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BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery

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FGF12 (Fibroblast Growth Factor 12) Inhibits Vascular Smooth Muscle Cell Remodeling in Pulmonary Arterial Hypertension

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Bone morphogenetic protein‐7 inhibits endothelial‐mesenchymal transition in pulmonary artery endothelial cell under hypoxia

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Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation

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Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease

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Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy

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