The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Impact of vitamin D on immune function: lessons learned from genome-wide analysis
Open accessAbstract
Immunomodulatory responses to the active form of vitamin D (1,25-dihydroxyvitamin D, 1,25D) have been recognized for many years, but it is only in the last 5 years that the potential role of this in normal human immune function has been recognized. Genome-wide analyses have played a pivotal role in redefining our perspective on vitamin D and immunity. The description of increased vitamin D receptor (VDR) and 1α-hydroxylase (CYP27B1) expression in macrophages following a pathogen challenge, has underlined the importance of intracrine vitamin D as key mediator of innate immune function. It is now clear that both macrophages and dendritic cells (DCs) are able to respond to 25-hydroxyvitamin D (25D), the major circulating vitamin D metabolite, thereby providing a link between the function of these cells and the variations in vitamin D status common to many humans. The identification of hundreds of primary 1,25D target genes in immune cells has also provided new insight into the role of vitamin D in the adaptive immune system, such as the modulation of antigen-presentation and T cells proliferation and phenotype, with the over-arching effects being to suppress inflammation and promote immune tolerance. In macrophages 1,25D promotes antimicrobial responses through the induction of antibacterial proteins, and stimulation of autophagy and autophagosome activity. In this way variations in 25D levels have the potential to influence both innate and adaptive immune responses. More recent genome-wide analyses have highlighted how cytokine signaling pathways can influence the intracrine vitamin D system and either enhance or abrogate responses to 25D. The current review will discuss the impact of intracrine vitamin D metabolism on both innate and adaptive immunity, whilst introducing the concept of disease-specific corruption of vitamin D metabolism and how this may alter the requirements for vitamin D in maintaining a healthy immune system in humans.
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Cites
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“The increasing availability of gene/protein expression databases for different cell types means that this type of strategy is likely to become a more prominent feature of genome-wide expression analyses in the future.”
BackgroundHepcidin and iron regulation, 10 years later
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“The increasing availability of gene/protein expression databases for different cell types means that this type of strategy is likely to become a more prominent feature of genome-wide expression analyses in the future.”
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Cited by
Vitamin D and the athlete: current perspectives and new challenges
Owens, D. J., Allison, R., & Close, G. L. (2018) · Sports Medicine · doi:10.1007/s40279-017-0841-9 · Cited by 223
Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the vitamin D receptor
Claro da Silva, T., Hiller, C., Gai, Z., & Kullak-Ublick, G. A. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.04.006 · Cited by 89
Vitamin D and the athlete: emerging insights
Owens, D. J., Fraser, W. D., & Close, G. L. (2015) · European Journal of Sport Science · doi:10.1080/17461391.2014.944223 · Cited by 81
Wang, Y., Zheng, J., Islam, M. S., Yang, Y., Hu, Y., & Chen, X. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59534 · Cited by 71
Metadata
- Authors
- Chun, R. F., Liu, P. T., Modlin, R. L., Adams, J. S., & Hewison, M.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2014-04-21
- Volume
- 5
- Pages
- 151-151
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W2035986671
- Cited by
- 399
- References
- 15
- FWCI
- 20.94
- Type
- journal article
- Language
- en
- Open access
- gold
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