Immunotherapy for cardiovascular disease
Open accessAbstract
The outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial have unequivocally proven that inflammation is a key driver of atherosclerosis and that targeting inflammation, in this case by using an anti-interleukin-1β antibody, improves cardiovascular disease (CVD) outcomes. This is especially true for CVD patients with a pro-inflammatory constitution. Although CANTOS has epitomized the importance of targeting inflammation in atherosclerosis, treatment with canakinumab did not improve CVD mortality, and caused an increase in infections. Therefore, the identification of novel drug targets and development of novel therapeutics that block atherosclerosis-specific inflammatory pathways and exhibit limited immune-suppressive side effects, as pursued in our collaborative research centre, are required to optimize immunotherapy for CVD. In this review, we will highlight the potential of novel immunotherapeutic targets that are currently considered to become a future treatment for CVD.
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The idea of antagonizing pro-inflammatory molecules upstream of the IL-1-IL-6/TNFα-CRP cascade or other immune regulators is viable, not only for a direct anti-inflammatory effect but also to ameliorate senescence.
“The idea of antagonizing pro-inflammatory molecules upstream of the IL-1-IL-6/TNFα-CRP cascade or other immune regulators145 is viable, not only for a direct anti-inflammatory effect but also to ameliorate senescence.”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [145]
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RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation
Moon, J.-S., Hisata, S., Park, M. A., DeNicola, G. M., Ryter, S. W., Nakahira, K., & Choi, A. M. K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.046 · Cited by 370 · see citing works
RetractedAntiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482 · see citing works
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works
A guide to immunometabolism for immunologists
O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.70 · Cited by 3,315 · see citing works
Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981 · see citing works
Collaborators, C. T. T. (. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60367-5 · Cited by 2,833 · see citing works
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works
The Biological Basis for Cardiac Repair After Myocardial Infarction
Prabhu, S. D., & Frangogiannis, N. G. (2016) · Circulation Research · doi:10.1161/circresaha.116.303577 · Cited by 2,249 · see citing works
Atherosclerosis: current pathogenesis and therapeutic options
Weber, C., & Noels, H. (2011) · Nature Medicine · doi:10.1038/nm.2538 · Cited by 2,203 · see citing works
Self-citationMichalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091 · see citing works
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
Griffith, J. W., Sokol, C. L., & Luster, A. D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120145 · Cited by 2,044 · see citing works
Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works
Chung, E. S., Packer, M., Lo, K. H., Fasanmade, A. A., & Willerson, J. T. (2003) · Circulation · doi:10.1161/01.cir.0000077913.60364.d2 · Cited by 1,644 · see citing works
Molecular mechanism and function of CD40/CD40L engagement in the immune system
Elgueta, R., Benson, M. J., de Vries, V. C., Wasiuk, A., Guo, Y., & Noelle, R. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00782.x · Cited by 1,633 · see citing works
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540 · see citing works
Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428 · see citing works
Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
Vats, D., Mukundan, L., Odegaard, J. I., Zhang, L., Smith, K. L., Morel, C. R., Greaves, D. R., Murray, P. J., & Chawla, A. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.011 · Cited by 1,369 · see citing works
Low-Dose Methotrexate for the Prevention of Atherosclerotic Events
Ridker, P. M., Everett, B. M., Pradhan, A., MacFadyen, J. G., Solomon, D. H., Zaharris, E., Mam, V., Hasan, A., Rosenberg, Y., Iturriaga, E., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1809798 · Cited by 1,317 · see citing works
Mann, D. L., McMurray, J. J. V., Packer, M., Swedberg, K., Borer, J. S., Colucci, W. S., Djian, J., Drexler, H., Feldman, A., Kober, L., et al. (2004) · Circulation · doi:10.1161/01.cir.0000124490.27666.b2 · Cited by 1,240 · see citing works
T cell metabolism drives immunity
Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,190 · see citing works
Macrophage Phenotype and Function in Different Stages of Atherosclerosis
Tabas, I., & Bornfeldt, K. E. (2016) · Circulation Research · doi:10.1161/circresaha.115.306256 · Cited by 1,121 · see citing works
Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease
Nidorf, S. M., Eikelboom, J. W., Budgeon, C. A., & Thompson, P. L. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.10.027 · Cited by 1,059 · see citing works
Prospects for combining targeted and conventional cancer therapy with immunotherapy
Gotwals, P. J., Cameron, S. B., Cipolletta, D., Cremasco, V., Crystal, A., Hewes, B., Mueller, B., Quaratino, S., Sabatos-Peyton, C. A., Petruzzelli, L., et al. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.17 · Cited by 948 · see citing works
L-arginine availability regulates T-lymphocyte cell-cycle progression.
Rodriguez, P. C., Quiceno, D. G., & Ochoa, A. C. (2007) · Blood · doi:10.1182/blood-2006-06-031856 · Cited by 926 · see citing works
Ridker, P. M., MacFadyen, J. G., Everett, B. M., Libby, P., Thuren, T. Y., Glynn, R. J., Ridker, P. M., MacFadyen, J. G., Everett, B. M., Libby, P., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32814-3 · Cited by 924 · see citing works
Reduction of atherosclerosis in mice by inhibition of CD40 signalling
Mach, F., Schönbeck, U., Sukhova, G. K., Atkinson, E., & Libby, P. (1998) · Nature · doi:10.1038/28204 · Cited by 910 · see citing works
Roubille, C., Richer, V., Starnino, T., McCourt, C., McFarlane, A., Fleming, P., Siu, S., Kraft, J., Lynde, C., Pope, J., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206624 · Cited by 907 · see citing works
Anti-Inflammatory Therapy With Canakinumab for the Prevention of Hospitalization for Heart Failure
Everett, B. M., Cornel, J. H., Lainscak, M., Anker, S. D., Abbate, A., Thuren, T., Libby, P., Glynn, R. J., & Ridker, P. M. (2019) · Circulation · doi:10.1161/circulationaha.118.038010 · Cited by 658 · see citing works
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, B., Yang, B., Ottaway, N., Smiley, D. L., Ma, T., Clemmensen, C., Chabenne, J., Zhang, L., Habegger, K. M., Fischer, K., et al. (2015) · Nature Medicine · doi:10.1038/nm.3761 · Cited by 645 · see citing works
Interleukin-1 Beta as a Target for Atherosclerosis Therapy
Libby, P. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.09.028 · Cited by 629 · see citing works
Kobiyama, K., & Ley, K. F. (2018) · Circulation Research · doi:10.1161/circresaha.118.313816 · Cited by 558 · see citing works
Ridker, P. M., Libby, P., MacFadyen, J. G., Thuren, T. Y., Ballantyne, C. M., Fonseca, F. A. H., Köenig, W., Shimokawa, H., Everett, B. M., & Glynn, R. J. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy310 · Cited by 556 · see citing works
Winkels, H., Ehinger, E., Vassallo, M., Buscher, K., Dinh, H. Q., Kobiyama, K., Hamers, A. A. J., Cochain, C., Vafadarnejad, E., Saliba, A.-E., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312513 · Cited by 547 · see citing works
The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease
Shirai, T., Nazarewicz, R. R., Wallis, B. B., Yanes, R. E., Watanabe, R., Hilhorst, M. L., Tian, L., Harrison, D. G., Giacomini, J. C., Assimes, T. L., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20150900 · Cited by 546 · see citing works
Jacobsson, L., Turesson, C., Gülfe, A., Kapetanovic, M. C., Petersson, I. F., Saxne, T., & Geborek, P. (2005) · PubMed · Cited by 533 · see citing works
The APEX AMI Investigators (2007) · JAMA · doi:10.1001/jama.297.1.43 · Cited by 447 · see citing works
Sleep modulates haematopoiesis and protects against atherosclerosis
McAlpine, C. S., Kiss, M. G., Rattik, S., He, S., Vassalli, A., Valet, C., Anzai, A., Chan, C. T., Mindur, J. E., Kahles, F., et al. (2019) · Nature · doi:10.1038/s41586-019-0948-2 · Cited by 447 · see citing works
Koenen, R. R., von Hundelshausen, P., Nesmelova, I. V., Zernecke, A., Liehn, E. A., Sarabi, A., Kramp, B. K., Piccinini, A. M., Paludan, S. R., Kowalska, M. A., et al. (2009) · Nature Medicine · doi:10.1038/nm.1898 · Cited by 440 · see citing works
Self-citationRequirement for CD154 in the progression of atherosclerosis
Lutgens, E., Gorelik, L., Daemen, M. J. A. P., de Muinck, E. D., Grewal, I. S., Koteliansky, V., & Flavell, R. A. (1999) · Nature Medicine · doi:10.1038/15271 · Cited by 439 · see citing works
Self-citationKim, K., Shim, D., Lee, J. S., Zaitsev, K., Williams, J. W., Kim, K.-W., Jang, M.-Y., Seok Jang, H., Yun, T. J., Lee, S. H., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.312804 · Cited by 434 · see citing works
Jourdan, T., Godlewski, G., Cinar, R., Bertola, A., Szanda, G., Liu, J., Tam, J., Han, T., Mukhopadhyay, B., Skarulis, M. C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3265 · Cited by 388 · see citing works
The mitochondrial citrate carrier: a new player in inflammation
Infantino, V., Convertini, P., Cucci, L., Panaro, M. A., Noia, M. A. D., Calvello, R., Palmieri, F., & Iacobazzi, V. (2011) · Biochemical Journal · doi:10.1042/bj20111275 · Cited by 386 · see citing works
Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
Schönbeck, U., Sukhova, G. K., Shimizu, K., Mach, F., & Libby, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7458 · Cited by 356 · see citing works
Greenberg, J. D., Kremer, J. M., Curtis, J. R., Hochberg, M. C., Reed, G., Tsao, P., Farkouh, M. E., Nasir, A., Setoguchi, S., & Solomon, D. H. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.129916 · Cited by 350 · see citing works
Frias, J. P., Bastyr, E. J., Vignati, L., Tschöp, M. H., Schmitt, C., Owen, K., Christensen, R. H., & DiMarchi, R. D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.011 · Cited by 321 · see citing works
ApoE attenuates unresolvable inflammation by complex formation with activated C1q
Yin, C., Ackermann, S., Ma, Z., Mohanta, S. K., Zhang, C., Li, Y., Nietzsche, S., Westermann, M., Peng, L., Hu, D., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0336-8 · Cited by 305 · see citing works
Self-citationBansal, S. S., Ismahil, M. A., Goel, M., Zhou, G., Rokosh, G. D., Hamid, T., & Prabhu, S. D. (2019) · Circulation · doi:10.1161/circulationaha.118.036065 · Cited by 302 · see citing works
Inflammation and immune system interactions in atherosclerosis
Legein, B., Temmerman, L., Biessen, E. A. L., & Lutgens, E. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1289-1 · Cited by 292 · see citing works
Self-citationMonocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice
Majmudar, M. D., Keliher, E. J., Heidt, T., Leuschner, F., Truelove, J. J., Sena, B. F., Gorbatov, R., Iwamoto, Y., Dutta, P., Wojtkiewicz, G. R., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.000116 · Cited by 289 · see citing works
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
Döring, Y., Pawig, L., Weber, C., & Noels, H. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00212 · Cited by 289 · see citing works
Self-citationBoth early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype
Lutgens, E., Cleutjens, K. B. J. M., Heeneman, S., Koteliansky, V., Burkly, L. C., & Daemen, M. J. A. P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7464 · Cited by 272 · see citing works
Self-citationAdaptive Response of T and B Cells in Atherosclerosis
Ketelhuth, D. F. J., & Hansson, G. K. (2016) · Circulation Research · doi:10.1161/circresaha.115.306427 · Cited by 269 · see citing works
Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice
Gomez, D. A., Baylis, R. A., Durgin, B. G., Newman, A. A. C., Alencar, G. F., Mahan, S., Hilaire, C. S., Müller, W., Waisman, A., Francis, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0124-5 · Cited by 256 · see citing works
Braza, M. S., van Leent, M. M. T., Lameijer, M., Sánchez-Gaytán, B. L., Arts, R. J. W., Pérez‐Medina, C., Conde, P., Garcia, M. R., González-Pérez, M., Brahmachary, M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.09.008 · Cited by 254 · see citing works
Self-citationO’Donoghue, M. L., Glaser, R., Cavender, M. A., Aylward, P. E., Bonaca, M. P., Budaj, A., Davies, R. Y., Dellborg, M., Fox, K. A. A., Gutierrez, J. A. T., et al. (2016) · JAMA · doi:10.1001/jama.2016.3609 · Cited by 249 · see citing works
Lutgens, E., Lievens, D., Beckers, L., Wijnands, E., Soehnlein, O., Zernecke, A., Seijkens, T. T. P., Engel, D. A., Cleutjens, J. P. M., Keller, A. M., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091293 · Cited by 247 · see citing works
Self-citationInterleukin-1 Blockade in Recently Decompensated Systolic Heart Failure
Tassell, B. W. V., Canada, J. M., Carbone, S., Trankle, C. R., Buckley, L. F., Oddi, C., Abouzaki, N. A., Dixon, D. L., Kadariya, D., Christopher, S., et al. (2017) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004373 · Cited by 247 · see citing works
Soehnlein, O., Drechsler, M. D., Döring, Y., Lievens, D., Hartwig, H., Kemmerich, K., Ortega‐Gómez, A., Mandl, M., Vijayan, S., Projahn, D., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201717 · Cited by 205 · see citing works
Self-citationNovel methodologies for biomarker discovery in atherosclerosis
Hoefer, I. E., Steffens, S., Ala‐Korpela, M., Bäck, M., Badimón, L., Bochaton‐Piallat, M., Boulanger, C. M., Caligiuri, G., Dimmeler, S., Egido, J., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv236 · Cited by 201 · see citing works
Self-citationDesprés, J., Ross, R., Boka, G., Alméras, N., & Lemieux, I. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.176362 · Cited by 198 · see citing works
Targeting CD40-induced TRAF6 signaling in macrophages reduces atherosclerosis
Seijkens, T. T. P., van Tiel, C. M., Kusters, P. J. H., Atzler, D., Soehnlein, O., Zarzycka, B., Aarts, S. A. B. M., Lameijer, M., Gijbels, M. J., Beckers, L., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.055 · Cited by 195 · see citing works
Self-citationFinan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Müller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.014 · Cited by 191 · see citing works
Self-citationGilbert, J., Lekstrom-Himes, J. A., Donaldson, D. D., Lee, Y., Hu, M., Xu, J., Wyant, T. L., & Davidson, M. H. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.11.005 · Cited by 186 · see citing works
Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity
Döring, Y., Noels, H., van der Vorst, E. P. C., Neideck, C., Egea, V., Drechsler, M. D., Mandl, M., Pawig, L., Jansen, Y. J. F. M., Schröder, K., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.027646 · Cited by 182 · see citing works
Self-citationTorre‐Amione, G., Anker, S. D., Bourge, R. C., Colucci, W. S., Greenberg, B., Hildebrandt, P. R., Keren, A., Motro, M., Moyé, L. A., Otterstad, J. E., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60134-8 · Cited by 177 · see citing works
Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.092 · Cited by 175 · see citing works
Self-citationCole, J. E., Park, I., Ahern, D., Kassiteridi, C., Danso‐Abeam, D., Goddard, M. E., Green, P. A., Maffia, P., & Monaco, C. G. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy109 · Cited by 172 · see citing works
Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques
Tomas, L., Edsfeldt, A., Mollet, I. G., Matic, L. P., Prehn, C. P., Adamski, J., Paulsson‐Berne, G., Hedin, U., Nilsson, J. Å., Bengtsson, E., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy124 · Cited by 169 · see citing works
Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease
He, S., Kahles, F., Rattik, S., Nairz, M., McAlpine, C. S., Anzai, A., Selgrade, D. F., Fenn, A. M., Chan, C. T., Mindur, J. E., et al. (2019) · Nature · doi:10.1038/s41586-018-0849-9 · Cited by 169 · see citing works
Hypothalamic innate immune reaction in obesity
Kälin, S., Heppner, F. L., Bechmann, I., Prinz, M., Tschöp, M. H., & Yi, C.-X. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.48 · Cited by 167 · see citing works
At the heart of the matter: the endocannabinoid system in cardiovascular function and dysfunction
Montecucco, F., & Marzo, V. D. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.002 · Cited by 166 · see citing works
de Azúa, I. R., Mancini, G., Srivastava, R. K., Rey, A. A., Cardinal, P., Tedesco, L., Zingaretti, C. M., Sassmann, A., Quarta, C., Schwitter, C., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci83626 · Cited by 160 · see citing works
Buono, C., Pang, H. B., Uchida, Y., Libby, P., Sharpe, A. H., & Lichtman, A. H. (2004) · Circulation · doi:10.1161/01.cir.0000127121.16815.f1 · Cited by 155 · see citing works
Bernatsky, S., Hudson, M., & Suissa, S. (2005) · Lara D. Veeken · doi:10.1093/rheumatology/keh610 · Cited by 154 · see citing works
Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation
von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M. N., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah6650 · Cited by 144 · see citing works
Self-citationSutton, G. M., Trevaskis, J. L., Hulver, M. W., McMillan, R. P., Markward, N., Babin, M. J., Meyer, E. A., & Butler, A. A. (2006) · Endocrinology · doi:10.1210/en.2005-1209 · Cited by 139 · see citing works
Lameijer, M., Binderup, T., van Leent, M. M. T., Senders, M. L., Fay, F., Malkus, J., Sánchez-Gaytán, B. L., Teunissen, A. J. P., Karakatsanis, N. A., Robson, P. M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0221-2 · Cited by 133 · see citing works
Self-citationTNFα drives mitochondrial stress in POMC neurons in obesity
Yi, C., Walter, M., Gao, Y., Pitra, S., Legutko, B., Kälin, S., Layritz, C., García‐Cáceres, C., Bielohuby, M., Bidlingmaier, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15143 · Cited by 131 · see citing works
Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance
Chatzigeorgiou, A., Seijkens, T. T. P., Zarzycka, B. A., Engel, D. A., Poggi, M., van den Berg, S. M., van den Berg, S. A. A., Soehnlein, O., Winkels, H., Beckers, L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400419111 · Cited by 127 · see citing works
Self-citationLiehn, E. A., Piccinini, A. M., Koenen, R. R., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.04.066 · Cited by 123 · see citing works
Alard, J.-É., Ortega‐Gómez, A., Wichapong, K., Bongiovanni, D., Horckmans, M., Megens, R. T. A., Leoni, G., Ferraro, B., Rossaint, J., Paulin, N., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad5330 · Cited by 123 · see citing works
Self-citationOverexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice
Matsumoto, T., Sasaki, N., Yamashita, T., Emoto, T., Kasahara, K., Mizoguchi, T., Hayashi, T., Yodoi, K., Kitano, N., Saito, T., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306848 · Cited by 118 · see citing works
Tuñón, J., Badimón, L., Bochaton‐Piallat, M., Cariou, B., Daemen, M. J. A. P., Egido, J., Evans, P. C., Hoefer, I. E., Ketelhuth, D. F. J., Lutgens, E., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy293 · Cited by 116 · see citing works
Self-citationCipollone, F., Ferri, C., Desideri, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103700.05109.0d · Cited by 115 · see citing works
Cole, J. E., Astola, N., Cribbs, A. P., Goddard, M. E., Park, I., Green, P. A., Davies, A. H., Williams, R. O., Feldmann, M., & Monaco, C. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517820112 · Cited by 108 · see citing works
A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome
Bowles, N. P., Karatsoreos, I. N., Li, X., Vemuri, K. V., Wood, J.-A., Li, Z., Tamashiro, K. L., Schwartz, G. J., Makriyannis, A., Kunos, G., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421420112 · Cited by 105 · see citing works
Melanocortin signaling in the CNS directly regulates circulating cholesterol
Pérez–Tilve, D., Hofmann, S. M., Basford, J. E., Nogueiras, R., Pfluger, P. T., Patterson, J. T., Grant, E., Wilson, H., Granholm, N. A., Arnold, M., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2569 · Cited by 103 · see citing works
CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease
Döring, Y., van der Vorst, E. P. C., Duchêne, J., Jansen, Y. J. F. M., Gencer, S., Bidzhekov, K., Atzler, D., Santovito, D., Rader, D. J., Saleheen, D., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.037953 · Cited by 97 · see citing works
Self-citationBlood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease
Sjaarda, J., Gerstein, H., Chong, M., Yusuf, S., Meyre, D., Anand, S. S., Hess, S., & Paré, G. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.04.067 · Cited by 94 · see citing works
Ma, K., Lv, S., Liu, B., Liu, Z., Luo, Y., Kong, W., Xu, Q., Feng, J., & Wang, X. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs330 · Cited by 87 · see citing works
Rinne, P., Guillamat‐Prats, R., Rami, M., Bîndilă, L., Ring, L., Lyytikäinen, L., Raitoharju, E., Oksala, N., Lehtimäki, T. J., Weber, C., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311185 · Cited by 87 · see citing works
Self-citationVajen, T., Koenen, R. R., Werner, I., Staudt, M., Projahn, D., Curaj, A., Sönmez, T. T., Simsekyilmaz, S., Schumacher, D., Möllmann, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29026-0 · Cited by 86 · see citing works
Self-citationde Boer, O. J., Hirsch, F., van der Wal, A. C., van der Loos, C. M., Das, P. K., & Becker, A. E. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00135-4 · Cited by 85 · see citing works
Discovery of Small Molecule CD40–TRAF6 Inhibitors
Zarzycka, B. A., Seijkens, T. T. P., Nabuurs, S. B., Ritschel, T., Grommes, J., Soehnlein, O., Schrijver, R., van Tiel, C. M., Hackeng, T. M., Weber, C., et al. (2015) · Journal of Chemical Information and Modeling · doi:10.1021/ci500631e · Cited by 82 · see citing works
Self-citationExploring immune checkpoints as potential therapeutic targets in atherosclerosis
Kusters, P. J. H., Lutgens, E., & Seijkens, T. T. P. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx248 · Cited by 80 · see citing works
Self-citationThe novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels
Mehta, N. N., Li, M., William, D. A., Khera, A. V., DerOhannessian, S. L., Qu, L., Ferguson, J. F., McLaughlin, C., Shaikh, L. H., Shah, R., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr091 · Cited by 76 · see citing works
CANTOS Trial Validates the Inflammatory Pathogenesis of Atherosclerosis
Weber, C., & von Hundelshausen, P. (2017) · Circulation Research · doi:10.1161/circresaha.117.311984 · Cited by 69 · see citing works
Self-citationChemokines Control Mobilization, Recruitment, and Fate of Monocytes in Atherosclerosis
Drechsler, M. D., Duchêne, J., & Soehnlein, O. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304649 · Cited by 65 · see citing works
Seijkens, T. T. P., Poels, K., Meiler, S. U., van Tiel, C. M., Kusters, P. J. H., Reiche, M. E., Atzler, D., Winkels, H., Tjwa, M., Poelman, H., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy714 · Cited by 65 · see citing works
Self-citationDöring, Y., Noels, H., Mandl, M., Kramp, B. K., Neideck, C., Lievens, D., Drechsler, M. D., Megens, R. T. A., Tilstam, P. V., Langer, M., et al. (2014) · Circulation Research · doi:10.1161/circresaha.114.302426 · Cited by 61 · see citing works
Self-citationRegulation of Adipose Tissue Metabolism by the Endocannabinoid System
van Eenige, R., van der Stelt, M., Rensen, P. C. N., & Kooijman, S. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.03.001 · Cited by 59 · see citing works
Lenglet, S., Thomas, A., Soehnlein, O., Montecucco, F., Burger, F., Pelli, G., Galan, K., Cravatt, B. F., Staub, C., & Steffens, S. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300275 · Cited by 57 · see citing works
Self-citationvan den Berg, S. M., Seijkens, T. T. P., Kusters, P. J. H., Zarzycka, B. A., Beckers, L., den Toom, M., Gijbels, M. J., Chatzigeorgiou, A., Weber, C., de Winther, M. P. J., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.198 · Cited by 56 · see citing works
Self-citationExpression and Cellular Localization of CXCR4 and CXCL12 in Human Carotid Atherosclerotic Plaques
Merckelbach, S., van der Vorst, E. P. C., Kallmayer, M. A., Rischpler, C., Burgkart, R., Döring, Y., de Borst, G., Schwaiger, M., Eckstein, H., Weber, C., et al. (2018) · Thrombosis and Haemostasis · doi:10.1160/th17-04-0271 · Cited by 56 · see citing works
Self-citationForteza, M. J., Polyzos, K. A., Baumgartner, R., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00950 · Cited by 52 · see citing works
Vujić, N., Schlager, S., Eichmann, T. O., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.10.109 · Cited by 51 · see citing works
Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome
Brandt, J., Herwald, H., Teupser, D., Küchenhoff, H., Karshovska, E., Mause, S. F., Siess, W., Wasmuth, H. E., Soehnlein, O., Koenen, R. R., et al. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-02-0139 · Cited by 47 · see citing works
Self-citationMelanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages
Rinne, P., Rami, M., Nuutinen, S., Santovito, D., van der Vorst, E. P. C., Guillamat‐Prats, R., Lyytikäinen, L., Raitoharju, E., Oksala, N., Ring, L., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.025889 · Cited by 46 · see citing works
Self-citationMeletta, R., Herde, A. M., Dennler, P., Fischer, E., Schibli, R., & Krämer, S. D. (2016) · EJNMMI Research · doi:10.1186/s13550-015-0157-4 · Cited by 40 · see citing works
Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van der Pol, S. M. A., Zarzycka, B. A., Heijnen, P. D. A. M., Beckers, L., den Toom, M., Gijbels, M. J., Boon, L., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0875-9 · Cited by 40 · see citing works
Self-citationHoyer, F. F., Khoury, M., Slomka, H., Kebschull, M., Lerner, R., Lutz, B., Schött, H.-F., Lütjohann, D., Wojtalla, A., Becker, A., et al. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.11.013 · Cited by 37 · see citing works
The Effect of Salsalate Therapy on Endothelial Function in a Broad Range of Subjects
Nohria, A., Kinlay, S., Buck, J. S., Redline, W. M., Copeland-Halperin, R. S., Kim, S.-R., & Beckman, J. A. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000609 · Cited by 37 · see citing works
ATVB Distinguished Scientist Award
Ley, K. F., Gerdes, N., & Winkels, H. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.308611 · Cited by 37 · see citing works
Herde, A. M., Mu, L., Meletta, R., Beck, K. R., Rančić, Z., Drandarov, K., Kaufmann, P. A., Ametamey, S. M., Schibli, R., Borel, N., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.04.071 · Cited by 34 · see citing works
T Cell Costimulatory and Coinhibitory Pathways in Vascular Inflammatory Diseases
Lichtman, A. H. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00018 · Cited by 32 · see citing works
Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E −/− Mice
Rinne, P., Kadiri, J. J., Velasco-Delgado, M., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310418 · Cited by 27 · see citing works
Ren, B., Kampen, E. V., van Berkel, T. J. C., Cruickshank, S. M., & Eck, M. V. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.11.018 · Cited by 25 · see citing works
Bosch, L., de Haan, J. J., Seijkens, T. T. P., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.12.076 · Cited by 19 · see citing works
Doesch, A. O., Zhao, L., Gleissner, C. A., Akhavanpoor, M., Rohde, D., Okuyucu, D., Hakimi, M., Katus, H. A., Erbel, C., & Dengler, T. J. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s59594 · Cited by 18 · see citing works
Maggi, P., Bruno, G., Perilli, F., Saracino, A., Volpe, A. R., Santoro, C. R., Ladisa, N., & Angarano, G. (2017) · In Vivo · doi:10.21873/invivo.11035 · Cited by 17 · see citing works
2016 Jeffrey M. Hoeg Award Lecture
Rouwet, E. V., & Lutgens, E. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.307742 · Cited by 14 · see citing works
Self-citationAbraham, M., Wald, H., Vaizel-Ohayon, D., Grabovsky, V., Oren, Z., Karni, A., Weiss, L., Galun, E., Peled, A., & Eizenberg, O. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01432 · Cited by 12 · see citing works
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Research works printed but not linked: 1
- Everett BM, Cornel J, Lainscak M, Anker SD, Abbate A, Thuren T, Libby P, Glynn RJ, Ridker PM. Anti-inflammatory therapy with canakinumab for the pre- vention of hospitalization for heart failure. Circulation 2018;99:3224.
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Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz919 · Cited by 188 · see citing works
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments
Li, G., Wan, Y., Jiao, A., Jiang, K., Cui, G., Tang, J., Yu, S., Hu, Z., Zhao, S., Yi, Z., et al. (2025) · Med Research · doi:10.1002/mdr2.70007 · Cited by 63 · see citing works
- Authors
- Lutgens, E., Atzler, D., Döring, Y., Duchene, J., Steffens, S., & Weber, C.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- German Centre for Cardiovascular Research (DE)
- Institute for Cardiovascular Prevention (IPEK), CRC 1123 Atherosclerosis – Mechanisms and Networks of novel therapeutic Targets, Ludwig-Maximilians-Universität, Ludwig-Maximilians-University Munich , Pettenkoferstraße 9, Munich 80336, Germany
- Maastricht University (NL)
- Corresponding author
- Weber, Christian
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-05-23
- Volume
- 40
- Issue
- 48
- Pages
- 3937-3946
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2946521848
- Cited by
- 192
- References
- 123
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 34 · 2023: 32 · 2022: 38 · 2021: 31 · 2020: 17 · 2019: 8
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation
- Dutch Federation of University Medical Centres
- the Netherlands Organisation for Health Research and Development
- Royal Netherlands Academy of Sciences for the GENIUS-II
- Netherlands Organization for Scientific Research
- NWO (016.130.676)
- EU (H2020-PHC-2015-667673)
- European Research Council (CD40-INN 681492)
- ERC (692511)
- German Centre for Cardiovascular Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- immunotherapy, cardiovascular disease, atherosclerosis, inflammation, canakinumab, IL-1β, CANTOS trial, anti-inflammatory therapy, infection risk, novel drug targets, inflammatory signaling
- MeSH terms
- Anti-Inflammatory Agents, Cardiovascular Diseases, Coronary Artery Disease, Humans, Immunologic Factors, Immunotherapy, Inflammation, Netherlands, Randomized Controlled Trials as Topic, Cytokines, Atherosclerosis, Interleukin-1beta, Antibodies, Monoclonal, Humanized
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