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Cited by 254

The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.

The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities

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Zoccal, Daniel B., Furuya, Werner I., Bassi, Mirian, Colombari, Débora S. A., Colombari, Eduardo·2014·Frontiers in Physiology
DOI 10.3389/fphys.2014.00238
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Abstract

It is well known that breathing introduces rhythmical oscillations in the heart rate and arterial pressure levels. Sympathetic oscillations coupled to the respiratory activity have been suggested as an important homeostatic mechanism optimizing tissue perfusion and blood gas uptake/delivery. This respiratory-sympathetic coupling is strengthened in conditions of blood gas challenges (hypoxia and hypercapnia) as a result of the synchronized activation of brainstem respiratory and sympathetic neurons, culminating with the emergence of entrained cardiovascular and respiratory reflex responses. Studies have proposed that the ventrolateral region of the medulla oblongata is a major site of synaptic interaction between respiratory and sympathetic neurons. However, other brainstem regions also play a relevant role in the patterning of respiratory and sympathetic motor outputs. Recent findings suggest that the neurons of the nucleus of the solitary tract (NTS), in the dorsal medulla, are essential for the processing and coordination of respiratory and sympathetic responses to hypoxia. The NTS is the first synaptic station of the cardiorespiratory afferent inputs, including peripheral chemoreceptors, baroreceptors and pulmonary stretch receptors. The synaptic profile of the NTS neurons receiving the excitatory drive from afferent inputs is complex and involves distinct neurotransmitters, including glutamate, ATP and acetylcholine. In the present review we discuss the role of the NTS circuitry in coordinating sympathetic and respiratory reflex responses. We also analyze the neuroplasticity of NTS neurons and their contribution for the development of cardiorespiratory dysfunctions, as observed in neurogenic hypertension, obstructive sleep apnea and metabolic disorders.

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Metadata

Authors
Zoccal, D. B., Furuya, W. I., Bassi, M., Colombari, D. S. A., & Colombari, E.
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2014-06-25
Volume
5
Pages
238-238
ISSN
1664-042X (ISSN-L)
DOI
10.3389/fphys.2014.00238
OpenAlex
W2058416358
Cited by
254
References
151
FWCI
4.00
Type
journal article
Language
en
Open access
gold

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