The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review
Open accessAbstract
Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD) characterized by iron-dependent accumulation of lipid peroxides. It is morphologically and biochemically different from known types of cell death. Ferroptosis plays a vital role in the treatment of tumors, renal failure, and ischemia reperfusion injury (IRI). Inhibition of glutathione peroxidase 4 (GPX4), starvation of cysteine, and peroxidation of arachidonoyl (AA) trigger ferroptosis in the cells. Iron chelators, lipophilic antioxidants, and specific inhibitor prevent ferroptosis. Although massive researches have demonstrated the importance of ferroptosis in human, its mechanism is not really clear. In this review, we distanced ourselves from this confusion by dividing the mechanisms of ferroptosis into two aspects: processes that facilitate the formation of lipid peroxides and processes that suppress the reduction of lipid peroxides. At the same time, we summarize the relations between ferroptosis and several types of cell death.
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Cites
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Cited by
Mitochondria regulation in ferroptosis
Wang, H., Liu, C., Zhao, Y., & Gao, G. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2019.151058 · Cited by 650
GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
Liu, Y., Wan, Y., Jiang, Y., Zhang, L., & Cheng, W. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188890 · Cited by 528
Molecular mechanisms of ferroptosis and their involvement in brain diseases
Costa, I., Barbosa, D. J., Benfeito, S., Silva, V., Chavarria, D., Borges, F., Remião, F., & Silva, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108373 · Cited by 402
Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer
Sia, J., Szmyd, R., Hau, E., & Gee, H. E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00041 · Cited by 378
Ferroptosis in Liver Diseases: An Overview
Capelletti, M. M., Manceau, H., Puy, H., & Peoc’h, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144908 · Cited by 361
Metadata
- Authors
- Lei, P., Bai, T., & Sun, Y.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2019-02-26
- Volume
- 10
- Pages
- 139-139
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W2917452836
- Cited by
- 532
- References
- 99
- FWCI
- 40.36
- Type
- journal article
- Language
- en
- Open access
- gold
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