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bZIPs and WRKYs: two large transcription factor families executing two different functional strategies

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Llorca, Carles M., Potschin, Maren, Zentgraf, Ulrike·2014·Frontiers in Plant Science

Abstract

bZIPs and WRKYs are two important plant transcription factor (TF) families regulating diverse developmental and stress-related processes. Since a partial overlap in these biological processes is obvious, it can be speculated that they fulfill non-redundant functions in a complex regulatory network. Here, we focus on the regulatory mechanisms that are so far described for bZIPs and WRKYs. bZIP factors need to heterodimerize for DNA-binding and regulation of transcription, and based on a bioinformatics approach, bZIPs can build up more than the double of protein interactions than WRKYs. In contrast, an enrichment of the WRKY DNA-binding motifs can be found in WRKY promoters, a phenomenon which is not observed for the bZIP family. Thus, the two TF families follow two different functional strategies in which WRKYs regulate each other's transcription in a transcriptional network whereas bZIP action relies on intensive heterodimerization.

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Metadata

Authors
Llorca, C. M., Potschin, M., & Zentgraf, U.
Venue
Frontiers in Plant Science
Published
2014-04-30
Volume
5
Pages
169-169
ISSN
1664-462X (ISSN-L)
OpenAlex
W2008651103
Cited by
197
References
5
FWCI
21.62
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: bZIPs and WRKYs: two large transcription factor families executing two different functional strategies. https://app.cochat.ai/papers/10.3389/fpls.2014.00169
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Llorca, C. M., Potschin, M., & Zentgraf, U. (2014). bZIPs and WRKYs: two large transcription factor families executing two different functional strategies. Frontiers in Plant Science. https://doi.org/10.3389/fpls.2014.00169

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