The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Salicylic acid signal transduction: the initiation of biosynthesis, perception and transcriptional reprogramming
Open accessAbstract
The phytohormone salicylic acid (SA) is a small phenolic compound that regulates diverse physiological processes, in particular plant resistance against pathogens. Understanding SA-mediated signaling has been a major focus of plant research. Pathogen-induced SA is mainly synthesized via the isochorismate pathway in chloroplasts, with ICS1 (ISOCHORISMATE SYNTHASE 1) being a critical enzyme. Calcium signaling regulates activities of a subset of transcription factors thereby activating nuclear ICS1 expression. The produced SA triggers extensive transcriptional reprogramming in which NPR1 (NON-EXPRESSOR of PATHOGENESIS-RELATED GENES 1) functions as the central coactivator of TGA transcription factors. Recently, two alternative but not exclusive models for SA perception mechanisms were proposed. The first model is that NPR1 homologs, NPR3 and NPR4, perceive SA thereby regulating NPR1 protein accumulation. The second model describes that NPR1 itself perceives SA, triggering an NPR1 conformational change thereby activating SA-mediated transcription. Besides the direct SA binding, NPR1 is also regulated by SA-mediated redox changes and phosphorylation. Emerging evidence show that pathogen virulence effectors target SA signaling, further strengthening the importance of SA-mediated immunity.
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Cites
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Hormonal Modulation of Plant Immunity
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Salicylic acid, a multifaceted hormone to combat disease
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Isochorismate synthase is required to synthesize salicylic acid for plant defence
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Hormone Crosstalk in Plant Disease and Defense: More Than Just JASMONATE-SALICYLATE Antagonism
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Inducers of Plant Systemic Acquired Resistance Regulate NPR1 Function through Redox Changes
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Systemic Acquired Resistance: Turning Local Infection into Global Defense
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The Language of Calcium Signaling
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Evolution of Hormone Signaling Networks in Plant Defense
Berens, M. L., Berry, H. M., Mine, A., Argueso, C. T., & Tsuda, K. (2017) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080516-035544 · Cited by 563
Self-citationSystems Biology of Plant-Microbiome Interactions
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Herrera-Vásquez, A., Salinas, P., & Holuigue, L. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00171 · Cited by 436
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Metadata
- Authors
- Seyfferth, C., & Tsuda, K.
- Venue
- Frontiers in Plant Science
- Publisher
- Frontiers Media SA
- Published
- 2014-12-09
- Volume
- 5
- Pages
- 697-697
- ISSN
- 1664-462X (ISSN-L)
- OpenAlex
- W2048535583
- Cited by
- 279
- References
- 113
- FWCI
- 15.14
- Type
- journal article
- Language
- en
- Open access
- gold
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