The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Heavy Metal Tolerance in Plants: Role of Transcriptomics, Proteomics, Metabolomics, and Ionomics
Open accessAbstract
Heavy metal contamination of soil and water causing toxicity/stress has become one important constraint to crop productivity and quality. This situation has further worsened by the increasing population growth and inherent food demand. It has been reported in several studies that counterbalancing toxicity due to heavy metal requires complex mechanisms at molecular, biochemical, physiological, cellular, tissue, and whole plant level, which might manifest in terms of improved crop productivity. Recent advances in various disciplines of biological sciences such as metabolomics, transcriptomics, proteomics, etc., have assisted in the characterization of metabolites, transcription factors, and stress-inducible proteins involved in heavy metal tolerance, which in turn can be utilized for generating heavy metal-tolerant crops. This review summarizes various tolerance strategies of plants under heavy metal toxicity covering the role of metabolites (metabolomics), trace elements (ionomics), transcription factors (transcriptomics), various stress-inducible proteins (proteomics) as well as the role of plant hormones. We also provide a glance of some strategies adopted by metal-accumulating plants, also known as "metallophytes."
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Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723
Hazards of heavy metal contamination
Järup, L. (2003) · British Medical Bulletin · doi:10.1093/bmb/ldg032 · Cited by 6,508
Heavy metals, occurrence and toxicity for plants: a review
Nagajyoti, P. C., Lee, K. D., & Sreekanth, T. V. M. (2010) · Environmental Chemistry Letters · doi:10.1007/s10311-010-0297-8 · Cited by 3,962
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
P HYTOCHELATINS AND M ETALLOTHIONEINS : Roles in Heavy Metal Detoxification and Homeostasis
Cobbett, C., & Goldsbrough, P. (2002) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.53.100301.135154 · Cited by 2,518
IRT1, an Arabidopsis Transporter Essential for Iron Uptake from the Soil and for Plant Growth
Vert, G., Grotz, N., Dédaldéchamp, F., Gaymard, F., Guerinot, M. L., Briat, J.-F., & Curie, C. (2002) · The Plant Cell · doi:10.1105/tpc.001388 · Cited by 1,679
Engineering drought tolerance in plants: discovering and tailoring genes to unlock the future
Umezawa, T., Fujita, M., Fujita, Y., Yamaguchi-Shinozaki, K., & Shinozaki, K. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.02.002 · Cited by 802
The molecular physiology of heavy metal transport in the Zn/Cd hyperaccumulator Thlaspi caerulescens
Pence, N. S., Larsen, P. B., Ebbs, S. D., Letham, D. L. D., Lasat, M. M., Garvin, D. F., Eide, D., & Kochian, L. V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4956 · Cited by 748
Krämer, U., Talke, I. N., & Hanikenne, M. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.010 · Cited by 583
Becher, M., Talke, I. N., Krall, L., & Krämer, U. (2004) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01959.x · Cited by 568
Cited by
Heavy Metal Contamination in Agricultural Soil: Environmental Pollutants Affecting Crop Health
Rashid, A., Schutte, B. J., Ulery, A., Deyholos, M. K., Sanogo, S., Lehnhoff, E. A., & Beck, L. (2023) · Agronomy · doi:10.3390/agronomy13061521 · Cited by 837
Cadmium stress in plants: A critical review of the effects, mechanisms, and tolerance strategies
El Rasafi, T., Oukarroum, A., Haddioui, A., Song, H., Kwon, E. E., Bolan, N., Tack, F. M. G., Sebastian, A., Prasad, M. N. V., & Rinklebe, J. (2022) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2020.1835435 · Cited by 601
Oleńska, E., Małek, W., Wójcik, M., Swiecicka, I., Thijs, S., & Vangronsveld, J. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.140682 · Cited by 555
Oxidative Stress and Antioxidant Metabolism under Adverse Environmental Conditions: a Review
García-Caparrós, P., De Filippis, L., Gul, A., Hasanuzzaman, M., Ozturk, M., Altay, V., & Lao, M. T. (2021) · The Botanical Review · doi:10.1007/s12229-020-09231-1 · Cited by 555
Phytoextraction of Heavy Metals: A Promising Tool for Clean-Up of Polluted Environment?
Suman, J., Uhlik, O., Viktorova, J., & Macek, T. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.01476 · Cited by 553
Metadata
- Authors
- Singh, S., Parihar, P., Singh, R., Singh, V. P., & Prasad, S. M.
- Venue
- Frontiers in Plant Science
- Publisher
- Frontiers Media SA
- Published
- 2016-02-08
- Volume
- 6
- Pages
- 1143-1143
- ISSN
- 1664-462X (ISSN-L)
- OpenAlex
- W2295482244
- Cited by
- 1,318
- References
- 18
- FWCI
- 84.44
- Type
- journal article
- Language
- en
- Open access
- gold
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- Singh, S., Parihar, P., Singh, R., Singh, V. P., & Prasad, S. M. (2016). Heavy Metal Tolerance in Plants: Role of Transcriptomics, Proteomics, Metabolomics, and Ionomics. Frontiers in Plant Science. https://doi.org/10.3389/fpls.2015.01143
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