The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Proof of Concept Trial of Dronabinol in Obstructive Sleep Apnea
Open accessAbstract
STUDY OBJECTIVE: Animal data suggest that Δ(9)-TetraHydroCannabinol (Δ(9)THC) stabilizes autonomic output during sleep, reduces spontaneous sleep-disordered breathing, and blocks serotonin-induced exacerbation of sleep apnea. On this basis, we examined the safety, tolerability, and efficacy of dronabinol (Δ(9)THC), an exogenous Cannabinoid type 1 and type 2 (CB1 and CB2) receptor agonist in patients with Obstructive Sleep Apnea (OSA). DESIGN AND SETTING: Proof of concept; single-center dose-escalation study of dronabinol. PARTICIPANTS: Seventeen adults with a baseline Apnea Hypopnea Index (AHI) ≥15/h. Baseline polysomnography (PSG) was performed after a 7-day washout of Continuous Positive Airway Pressure treatment. INTERVENTION: Dronabinol was administered after baseline PSG, starting at 2.5 mg once daily. The dose was increased weekly, as tolerated, to 5 mg and finally to 10 mg once daily. MEASUREMENTS AND RESULTS: Repeat PSG assessments were performed on nights 7, 14, and 21 of dronabinol treatment. Change in AHI (ΔAHI, mean ± SD) was significant from baseline to night 21 (-14.1 ± 17.5; p = 0.007). No degradation of sleep architecture or serious adverse events was noted. CONCLUSION: Dronabinol treatment is safe and well-tolerated in OSA patients at doses of 2.5-10 mg daily and significantly reduces AHI in the short-term. These findings should be confirmed in a larger study in order to identify sub-populations with OSA that may benefit from cannabimimetic pharmacologic therapy.
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“PSYCHIATRY ORIGINAL RESEARCH ARTICLE published: 22 January 2013 doi: 10.3389/fpsyt.2013.00001 Proof of concept trial of dronabinol in obstructive sleep apnea”
BackgroundInfluentialEndocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action
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Drug therapy for obstructive sleep apnoea in adults
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Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons
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Resting-state functional connectivity in major depressive disorder: A review
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van Heeringen, K., & Mann, J. J. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)70220-2 · Cited by 550
Cannabis use and cannabis use disorder
Connor, J. P., Stjepanović, D., Le Foll, B., Hoch, E., Budney, A. J., & Hall, W. D. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00247-4 · Cited by 552
Cannabis, Cannabinoids, and Sleep: a Review of the Literature
Babson, K. A., Sottile, J., & Morabito, D. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0775-9 · Cited by 484
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Lv, R., Liu, X., Zhang, Y., Dong, N., Wang, X., He, Y., Yue, H., & Yin, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01496-3 · Cited by 477
Metadata
- Authors
- Prasad, B., Radulovacki, M. G., & Carley, D. W.
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 1-1
- ISSN
- 1664-0640 (ISSN-L)
- OpenAlex
- W2154294420
- Cited by
- 423
- References
- 18
- FWCI
- 32.64
- Type
- journal article
- Language
- en
- Open access
- gold
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