Obesity after kidney transplantation-results of a KTx360° substudy
Open accessAbstract
Objective: There is solid evidence that kidney transplant (KTx) patients are susceptible to weight gain after transplantation. Post-transplantation obesity (BMI ≥ 30 kg/m2) seems to be associated with higher risks of hypertension, dyslipidemia, diabetes mellitus, and cardiovascular events, while there are contradicting findings regarding the association between obesity and mortality, graft failure after transplantation as well as other variables. We aimed to evaluate the course of weight after KTx and to assess the prevalence of post-transplant obesity in a large sample of German KTx patients. Further, we focused on potential associations between weight gain, obesity and BMI after transplantation with sociodemographic, medical, psychological (levels of anxiety and depression measured with the Hospital Anxiety and Depression Scale (HADS)), and donation-specific variables. Methods: In a structured post-transplant care program 433 KTx patients were evaluated at Hannover Medical School. Information on the pre-transplant body weight / dry weight of dialysis patients was taken from the electronic patient charts. At post-transplant assessment body weight was measured in the transplant center. For statistical analyses, descriptive statistics, analyses of variance, tests for correlations, and regression analyses were used. Results: Mean age was 51.3 years, 59% were male and 26.3% had ≥12 years of school attendance. Regarding somatic conditions 6.0% were suffering from type 2 diabetes mellitus, 6.9% were affected by NODAT and the mean estimated glomerular filtration rate (eGFR) was 47.7 ml/min/1.73m2. The prevalence rates of obesity before and after kidney transplantation were 14.8% and 19.9%, respectively. This represents an increase of 34%. Obesity after transplantation was associated with higher rates of type 2 diabetes mellitus and of new onset diabetes after transplantation (NODAT). Additionally, there was an association between increasing pre-transplant as well as post-transplant BMI and decreasing eGFR. Higher age and female sex were associated with higher rates of post-transplant obesity. Conclusions: Our results suggest that obesity represents a serious problem in KTx patients, especially regarding the association between increasing BMI and decreasing graft functioning (eGFR). However, this aspect is often overlooked and information on effective treatment options for these patients are scarce making further research on this topic necessary.
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Post-transplant BMI categories are strongly associated with type 2 diabetes mellitus and new-onset diabetes after transplantation (NODAT).
“There was a strong association between post-transplant BMI categories and type 2 diabetes mellitus as well as new-onset diabetes after transplantation (NODAT).”
In a large German sample of 433 patients, obesity frequency was 14.8% before kidney transplantation and 19.9% after kidney transplantation.
“In a large German sample of patients before and after kidney transplantation (n = 433), the frequencies of obesity (BMI > 30 kg/m2) were 14.8% (before KTx) and 19.9% (after KTx), respectively.”
Increasing BMI is associated with decreasing graft functioning (eGFR).
“Above that, an association between increasing BMI and decreasing graft functioning (eGFR) was found (18).”
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“Above that, an association between increasing BMI and decreasing graft functioning (eGFR) was found (18).”
BackgroundSelf-citation
- Authors
- Nöhre, M., Schieffer, E., Hanke, A., Pape, L., Schiffer, L., Schiffer, M., & de Zwaan, M.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Nöhre, Mariel
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2020-05-08
- Volume
- 11
- Pages
- 399-399
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC7227415
- OpenAlex
- W3021932620
- Cited by
- 27
- References
- 43
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 1
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- OPUS Repository (Kooperativer Bibliotheksverbund Berlin-Brandenburg) (submittedVersion, cc-by)
- Funders
- Gemeinsame Bundesausschuss (01NVF16009)
- Topics
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- post-transplant obesity, kidney transplantation, body mass index, weight gain, graft function, estimated glomerular filtration rate, post-transplant diabetes mellitus, type 2 diabetes, anxiety, depression, sociodemographic factors, obesity prevalence
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