The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome—An Update
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“Bloating has a multifactorial etiology and SIBO, which is an intestinal microbiome dysbiosis, appears to be commonly associated with this symptom and with IBS [16].”
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Foodborne illness acquired in the United States—Major pathogens
Scallan, E., Hoekstra, R. M., Angulo, F. J., Tauxe, R. V., Widdowson, M.-A., Roy, S. L., Jones, J. L., & Griffin, P. M. (2011) · Emerging Infectious Diseases · doi:10.3201/eid1701.p11101 · Cited by 7,657
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Review article: the role of butyrate on colonic function
HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721
Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis
Lovell, R. M., & Ford, A. C. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.02.029 · Cited by 2,155
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation
Pimentel, M., Lembo, A., Chey, W. D., Zakko, S., Ringel, Y., Yu, J., Mareya, S. M., Shaw, A. L., Bortey, E., & Forbes, W. P. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1004409 · Cited by 1,036
Self-citationActivation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757
Ford, A. C., Harris, L. A., Lacy, B. E., Quigley, E. M. M., & Moayyedi, P. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15001 · Cited by 619
Research works printed but not linked: 75
- Lacy, 2016, Bowel Disorders, Gastroenterology, 150, 10.1053/j.gastro.2016.02.031 · DOI · Paper page
- Rezaie, 2017, Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus, Am J Gastroenterol, 112, 10.1038/ajg.2017.46 · DOI · Paper page
- Pimentel, 2020, ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth, Am J Gastroenterol, 115, 10.14309/ajg.0000000000000501 · DOI · Paper page
- Levitt, 1971, Volume and composition of human intestinal gas determined by means of an intestinal washout technic, N Engl J Med, 284, 10.1056/NEJM197106242842502 · DOI
- Bond, 1971, Factors influencing pulmonary methane excretion in man. An indirect method of studying the in situ metabolism of the methane-producing colonic bacteria, J Exp Med, 133, 10.1084/jem.133.3.572 · DOI · Paper page
- Christl, 1992, Production, metabolism, and excretion of hydrogen in the large intestine, Gastroenterology, 102, 10.1016/0016-5085(92)90765-Q · DOI
- Hwang, 2010, Evaluating breath methane as a diagnostic test for constipation-predominant IBS, Dig Dis Sci, 55, 398, 10.1007/s10620-009-0778-4 · DOI
- Ghoshal, 2016, Irritable Bowel Syndrome, Particularly the Constipation-Predominant Form, Involves an Increase in Methanobrevibacter smithii, Which Is Associated with Higher Methane Production, Gut Liver, 10, 10.5009/gnl15588 · DOI
- Takakura, 2019, Patients with Appendectomy Have Significantly Less Methane in Their Exhaled Breath: is the Appendix a Vestigial Organ Or an Important Reservoir for Methanogens, Gastroenterology, 156, S, 10.1016/S0016-5085(19)39870-1 · DOI
- Weaver, 1986, Incidence of methanogenic bacteria in a sigmoidoscopy population: an association of methanogenic bacteria and diverticulosis, Gut, 27, 698, 10.1136/gut.27.6.698 · DOI
- Eckburg, 2005, Diversity of the human intestinal microbial flora, Science, 308, 10.1126/science.1110591 · DOI · Paper page
- Shah, 2020, Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies, Am J Gastroenterol, 115, 190, 10.14309/ajg.0000000000000504 · DOI
- Wu, 2019, Small intestinal bacterial overgrowth is associated with Diarrhea-predominant irritable bowel syndrome by increasing mainly Prevotella abundance, Scand J Gastroenterol, 54, 1, 10.1080/00365521.2019.1694067 · DOI
- Parodi, 2009, Positive glucose breath testing is more prevalent in patients with IBS-like symptoms compared with controls of similar age and gender distribution, J Clin Gastroenterol, 43, 10.1097/MCG.0b013e3181a099a5 · DOI
- Park, 2010, [Usefulness of lactulose breath test for the prediction of small intestinal bacterial overgrowth in irritable bowel syndrome], Korean J Gastroenterol, 56, 10.4166/kjg.2010.56.4.242 · DOI
- Sachdeva, 2011, Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: frequency and predictors, J Gastroenterol Hepatol, 10.1111/j.1440-1746.2011.06654.x · DOI
- Bertelè, 2012, P.07.16 Bacterial Overgrowth In Irritable Bowel Syndrome: A Cohort Study, Digest Liver Dis, 44, S132, 10.1016/S1590-8658(12)60365-X · DOI
- Philip, 2013, SI-11 Prevalence of small intestinal bacterial overgrowth in patients with irritable bowel syndrome using lactulose hydrogen breath test, Indian J Gastroenterol, 32, 1, 10.1007/s12664-013-0417-z · DOI
- Qing, 2013, Relationship betweeen the irritable bowel syndrome and small intestinal bacterial, J Gastroenterol Hepatol, 28, 23
- Li, 2014, Measurement of methane and hydrogen on lactulose breath test detects small intestinal bacterial overgrowth in patients with irritable bowel syndrome, Neurogastroenterol Motil, 26, 11
- Moraru, 2014, Small intestinal bacterial overgrowth is associated to symptoms in irritable bowel syndrome. Evidence from a multicentre study in Romania, Rom J Intern Med, 52
- Lombardo, 2010, Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy, Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc, 8, 10.1016/j.cgh.2009.12.022 · DOI · Paper page
- Evans, 2012, PWE-050 Does small intestine bacterial overgrowth cause neurodysmotility in IBS and coeliac disease, Gut, 61, 10.1136/gutjnl-2012-302514d.50 · DOI
- Abbasi, 2015, Small bowel bacterial overgrowth in patients with irritable bowel syndrome: the first study in iran, Middle East J Dig Dis, 7, 36
- Chu, 2016, Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines, Gastroenterol Res Pract, 2016, 3230859, 10.1155/2016/3230859 · DOI
- Pimentel, 2003, Methane production during lactulose breath test is associated with gastrointestinal disease presentation, Dig Dis Sci, 48, 86, 10.1023/A:1021738515885 · DOI
- Chatterjee, 2007, The degree of breath methane production in IBS correlates with the severity of constipation, Am J Gastroenterol, 102, 10.1111/j.1572-0241.2007.01072.x · DOI
- Suri, 2018, Elevated methane levels in small intestinal bacterial overgrowth suggests delayed small bowel and colonic transit, Med (Baltimore), 97, e10554, 10.1097/MD.0000000000010554 · DOI
- Miller, 1985, Methanosphaera stadtmaniae gen. nov., sp. nov.: a species that forms methane by reducing methanol with hydrogen, Arch Microbiol, 141, 10.1007/BF00423270 · DOI · Paper page
- Miller, 1982, Isolation of Methanobrevibacter smithii from human feces, Appl Environ Microbiol, 43, 10.1128/AEM.43.1.227-232.1982 · DOI
- Kim, 2012, Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath, Dig Dis Sci, 57, 10.1007/s10620-012-2197-1 · DOI
- Florin, 1995, Inhibition of methanogenesis by human bile, Gut, 37, 10.1136/gut.37.3.418 · DOI
- Leite, 2020, The microbiome in small intestinal bacterial overgrowth: the REIMAGINE study, PloS One, 10.1371/journal.pone.0234906 · DOI
- Ghoshal, 2014, Breath tests in the diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome in comparison with quantitative upper gut aspirate culture, Eur J Gastroenterol Hepatol, 26, 10.1097/MEG.0000000000000122 · DOI · Paper page
- Pyleris, 2012, The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture: relationship with irritable bowel syndrome, Dig Dis Sci, 57, 10.1007/s10620-012-2033-7 · DOI
- Rezaie, 2017, Autoimmunity as a Potential Cause of Post-Infectious Gut Dysmotility: A Longitudinal Observation, Am J Gastroenterol, 112, 10.1038/ajg.2017.8 · DOI
- Cohen, 2013, Increased risk for irritable bowel syndrome after acute diverticulitis, Clin Gastroenterol Hepatol, 11, 10.1016/j.cgh.2013.03.007 · DOI
- Shah, 2012, Estimating the contribution of acute gastroenteritis to the overall prevalence of irritable bowel syndrome, J Neurogastroenterol Motil, 18, 10.5056/jnm.2012.18.2.200 · DOI
- Zuckerman, 1993, Intestinal permeability to [51Cr]EDTA in infectious diarrhea, Dig Dis Sci, 38, 10.1007/BF01303174 · DOI
- Dunlop, 2006, Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes, Am J Gastroenterol, 101, 10.1111/j.1572-0241.2006.00672.x · DOI · Paper page
- Zhang, 2010, Enteropathogenic Escherichia coli changes distribution of occludin and ZO-1 in tight junction membrane microdomains in vivo, Microb Pathog, 48, 28, 10.1016/j.micpath.2009.10.002 · DOI
- Hullar, 2014, Diet, the gut microbiome, and epigenetics, Cancer J, 20, 10.1097/PPO.0000000000000053 · DOI
- Pozuelo, 2015, Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome, Sci Rep, 5, 12693, 10.1038/srep12693 · DOI
- Moloney, 2015, Early-life stress-induced visceral hypersensitivity and anxiety behavior is reversed by histone deacetylase inhibition, Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc, 27, 10.1111/nmo.12675 · DOI
- Rapin, 2010, Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine, Clinics (Sao Paulo), 65, 10.1590/S1807-59322010000600012 · DOI
- Hulsewe, 2004, Does glutamine-enriched parenteral nutrition really affect intestinal morphology and gut permeability, Clin Nutr, 23, 10.1016/j.clnu.2004.04.002 · DOI
- Bercik, 2004, Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction, Gastroenterology, 127, 10.1053/j.gastro.2004.04.006 · DOI
- Chen, 2017, Reduced interstitial cells of Cajal and increased intraepithelial lymphocytes are associated with development of small intestinal bacterial overgrowth in post-infectious IBS mouse model, Scand J Gastroenterol, 52, 10.1080/00365521.2017.1342141 · DOI
- Pimentel, 2008, A new rat model links two contemporary theories in irritable bowel syndrome, Dig Dis Sci, 53, 10.1007/s10620-007-9977-z · DOI
- Pokkunuri, 2012, Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome, J Neurogastroenterol Motil, 18, 10.5056/jnm.2012.18.4.434 · DOI
- Pimentel, 2015, Autoimmunity Links Vinculin to the Pathophysiology of Chronic Functional Bowel Changes Following Campylobacter jejuni Infection in a Rat Model, Dig Dis Sci, 60, 10.1007/s10620-014-3435-5 · DOI
- Bays, 2017, Vinculin in cell-cell and cell-matrix adhesions, Cell Mol Life Sci, 74, 2999, 10.1007/s00018-017-2511-3 · DOI · Paper page
- Schmulson, 2016, Clinical experience with the use of anti-CdtB and anti-vinculin antibodies in patients with diarrhea in Mexico, Rev Gastroenterol Mex, 81, 10.1016/j.rgmxen.2016.07.002 · DOI
- Rezaie, 2017, Assessment of Anti-vinculin and Anti-cytolethal Distending Toxin B Antibodies in Subtypes of Irritable Bowel Syndrome, Dig Dis Sci, 62, 10.1007/s10620-017-4585-z · DOI
- Morales, 2019, Second-Generation Biomarker Testing for Irritable Bowel Syndrome Using Plasma Anti-CdtB and Anti-Vinculin Levels, Dig Dis Sci, 64, 10.1007/s10620-019-05684-6 · DOI
- Pike, 2015, Immunological Biomarkers in Postinfectious Irritable Bowel Syndrome, J Travel Med, 22, 10.1111/jtm.12218 · DOI
- Talley, 2019, Circulating Anti-cytolethal Distending Toxin B and Anti-vinculin Antibodies as Biomarkers in Community and Healthcare Populations With Functional Dyspepsia and Irritable Bowel Syndrome, Clin Transl Gastroenterol, 10, e00064, 10.14309/ctg.0000000000000064 · DOI
- Gasbarrini, 2007, Small intestinal bacterial overgrowth: diagnosis and treatment, Dig Dis, 25, 10.1159/000103892 · DOI
- Bala, 2006, Malabsorption syndrome with and without small intestinal bacterial overgrowth: a study on upper-gut aspirate using 1H NMR spectroscopy, Magn Reson Med, 56, 10.1002/mrm.21041 · DOI
- Shah, 2013, Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth, Aliment Pharmacol Ther, 38, 10.1111/apt.12479 · DOI
- Pimentel, 2017, Repeat Rifaximin for Irritable Bowel Syndrome: No Clinically Significant Changes in Stool Microbial Antibiotic Sensitivity, Dig Dis Sci, 62, 10.1007/s10620-017-4598-7 · DOI
- Fodor, 2019, Rifaximin is associated with modest, transient decreases in multiple taxa in the gut microbiota of patients with diarrhoea-predominant irritable bowel syndrome, Gut Microbes, 10, 22, 10.1080/19490976.2018.1460013 · DOI
- Low, 2010, A combination of rifaximin and neomycin is most effective in treating irritable bowel syndrome patients with methane on lactulose breath test, J Clin Gastroenterol, 44, 10.1097/MCG.0b013e3181c64c90 · DOI · Paper page
- Pimentel, 2006, Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study, Dig Dis Sci, 51, 10.1007/s10620-006-9104-6 · DOI · Paper page
- Rezaie, 2019, Lactulose Breath Testing as a Predictor of Response to Rifaximin in Patients With Irritable Bowel Syndrome With Diarrhea, Am J Gastroenterol, 114, 10.14309/ajg.0000000000000444 · DOI
- Gupta, 2016, Breath Testing for Small Intestinal Bacterial Overgrowth: A Means to Enrich Rifaximin Responders in IBS Patients, Am J Gastroenterol, 111, 10.1038/ajg.2016.32 · DOI
- Luscombe, 2000, Health-related quality of life and associated psychosocial factors in irritable bowel syndrome: a review, Qual Life Res, 9, 10.1023/A:1008970312068 · DOI
- Gaynes, 1999, The role of psychosocial factors in irritable bowel syndrome, Baillieres Best Pract Res Clin Gastroenterol, 13, 10.1053/bega.1999.0038 · DOI
- Rao, 2018, Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis, Clin Transl Gastroenterol, 9, 162, 10.1038/s41424-018-0030-7 · DOI
- Thompson, 2012, Current management of short bowel syndrome, Curr Probl Surg, 49, 52, 10.1067/j.cpsurg.2011.10.002 · DOI
- Jackson, 2015, Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study, Sleep Sci, 8, 10.1016/j.slsci.2015.10.001 · DOI
- Leite, 2019, Optimizing microbiome sequencing for small intestinal aspirates: validation of novel techniques through the REIMAGINE study, BMC Microbiol, 19, 239, 10.1186/s12866-019-1617-1 · DOI
- Saffouri, 2019, Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders, Nat Commun, 10, 2012, 10.1038/s41467-019-09964-7 · DOI
- Linden, 2014, Hydrogen sulfide signaling in the gastrointestinal tract, Antioxid Redox Signal, 20, 10.1089/ars.2013.5312 · DOI
- Singer-Englar, 2018, 182 - Competitive Hydrogen Gas Utilization by Methane- and Hydrogen Sulfide-Producing Microorganisms and Associated Symptoms: Results of a Novel 4-Gas Breath Test Machine, Gastroenterology, 154, S, 10.1016/S0016-5085(18)30625-5 · DOI
Cited by
Hammer, H. F., Fox, M. R., Keller, J., Salvatore, S., Basilisco, G., Hammer, J., Lopetuso, L., Benninga, M., Borrelli, O., Dumitrascu, D., et al. (2022) · United European Gastroenterology Journal · doi:10.1002/ueg2.12133 · Cited by 189
Giacosa, A., Riva, A., Petrangolini, G., Allegrini, P., Fazia, T., Bernardinelli, L., Peroni, G., & Rondanelli, M. (2022) · Nutrients · doi:10.3390/nu14030416 · Cited by 24
Metadata
- Authors
- Takakura, W., & Pimentel, M.
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2020-07-10
- Volume
- 11
- ISSN
- 1664-0640
- Cited by
- 148
- References
- 23
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