CoChat
Sign Up
Cited by 6Fibromyalgia and Chronic Fatigue Syndrome ResearchPhysical Activity and HealthMusculoskeletal pain and rehabilitation

Efficiency of an Optimized Care Organization in Fibromyalgia Patients: The From Intent to Move (FIMOUV) Study Protocol of a Randomized Controlled Trial

Open access
Colas, Claire, Goutte, Julie, Creac'h, Christelle, Fontana, Luc, Vericel, Marie-Pierre, Manzanares, Jessica, Peuriere, Marie, Akrour, Madjid +12 more·2021·Frontiers in Public Health
DOI 10.3389/fpubh.2021.554291PMC PMC8185292
Open this paper in CoChat — free accountOpen PDF

Abstract

Introduction: Fibromyalgia (FM) is characterized by multiple symptoms including pain, fatigue, and sleep disorders, altering patient's quality of life. In the absence of effective pharmacological therapy, the last European guidelines recommend a multidisciplinary management based on exercise and education. Thus, our main objective was to measure the effectiveness of a healthcare organization offering a specific program of adapted physical activity combined with a therapeutic education program for FM patients. Methods and Analysis: The From Intent To Move (FIMOUV) study will recruit 330 FM patients randomized into two groups: test and control. The test group will benefit from a 1-month mixed exercise training program supervised at the hospital, followed by 2 months in a community-based relay in a health-sport structure. In addition, each of the two groups will benefit from therapeutic patient education sessions. The main endpoint is the measurement of the level of physical activity by accelerometry at 1 year. The secondary endpoints concern adherence to the practice of physical activity, impact on lifestyle, state of health, and physical capacity, as well as an estimate of the budgetary impact of this management strategy. Discussion: This interventional research will allow us to assess the evolution of behaviors in physical activity after an FM syndrome management based solely on patient education or based on a supervised and adapted practice of physical activity associated with this same therapeutic education program. It seems to be the first study evaluating the impact of its intervention on objective data for measuring physical activity and sedentary behavior via accelerometry among FM patients. Trial registration:ClinicalTrials.gov NCT04107948.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fpubh.2021.554291

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Fibromyalgia is a disabling chronic pain syndrome characterized by multiple symptoms, including medically unexplained widespread pain, fatigue, cognitive, mood and sleep disorders.

    “Fibromyalgia (FM) is a disabling chronic pain syndrome characterized by multiple symptoms, including medically unexplained widespread pain, fatigue, cognitive, mood and sleep disorders.1–11”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [5]

    The Introduction (page not specified) describes fibromyalgia as a syndrome involving pain, fatigue and sleep disorders that alters quality of life; it also specifies chronic pain across multiple body regions and discusses anxiety and depression in patients. It does not describe cognitive disorders or characterize the pain as medically unexplained. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • FM has an unknown aetiology but has been described as a complex hyperalgesic pain syndrome in which abnormalities of central sensory processing interact with peripheral pain generators.

    “FM has an unknown aetiology but has been described as a complex hyperalgesic pain syndrome in which abnormalities of central sensory processing interact with peripheral pain generators.1,5,7”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [5]

    The Introduction (page not supplied) says FM physiopathology is poorly understood and evokes central nervous system dysfunction involving pain pathways. It does not describe FM as a hyperalgesic syndrome or say that central sensory-processing abnormalities interact with peripheral pain generators. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Moderate exercise, integrative neuromuscular training, Tai Chi, and Virtual Reality (VR) based exergaming show promise in improving postural stability and physical functioning.

    “Moderate exercise, integrative neuromuscular training, Tai Chi, and Virtual Reality (VR) based exergaming show promise in improving postural stability and physical functioning.5,24”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [5]

    The Introduction (page not provided) reports improved physical function with mixed exercise training in adults with fibromyalgia, and the Methods and Analysis > Interventions section includes an exercise that solicits balance. The paper does not address integrative neuromuscular training, Tai Chi, or VR exergaming, or report an improvement in postural stability; its own intervention is a study protocol, not a reported result. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Regular moderate to vigorous physical activity and weight-bearing exercises are recommended for pain management in patients with FM, but adherence to these recommendations is often poor.

    “Regular moderate to vigorous physical activity and weight-bearing exercises are recommended for pain management in patients with FM,5,21 but adherence to these recommendations is often poor.9,17,30”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [5]

    The Introduction (page unavailable) says endurance training is recommended for fibromyalgia and favors moderate-to-vigorous activity over light-intensity activity for reducing symptoms. It also reports reduced pain perception with resistance training, but says there are no precise recommendations on training modalities; it does not establish a specific recommendation for weight-bearing exercise. The poor-adherence clause has separate citations in the citing sentence and is not attributed to this source. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • The literature is scarce and there are no precise recommendations regarding frequency, intensity or type of exercise for fibromyalgia.

    “Exercise has low to moderate effects on fatigue for FM patients; however, at this juncture, the literature is scarce and there are no precise recommendations regarding frequency, intensity or type.5”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [5]

    The Introduction (page not provided) explicitly says there are no precise exercise recommendations for fibromyalgia after discussing frequency, intensity and type. It describes HIIT as minimally studied and strength training as less documented than aerobic training, but does not say exercise literature overall is scarce. It also notes exercise’s relevance to fatigue without specifying a low-to-moderate effect. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 41

  1. [1]Vincent A Lahr BD Wolfe F Clauw DJ Whipple MO Oh TH. Prevalence of fibromyalgia: a population-based study in olmsted county, minnesota, utilizing the rochester epidemiology project. Arthr Care Res (Hoboken). (2013) 65: 786– 92. 10.1002/acr.21896 23203795 PMC3935235 · DOI
  2. [2]Wolfe F Smythe HA Yunus MB Bennett RM Bombardier C Goldenberg DL. The american college of rheumatology 1990 criteria for the classification of fibromyalgia. Arthr Rheum. (1990) 33: 160– 72. 10.1002/art.1780330203 2306288 · DOI · Paper page
  3. [3]Abeles AM Pillinger MH Solitar BM Abeles M. Narrative review: the pathophysiology of fibromyalgia. Ann Intern Med. (2007) 146: 726– 34. 10.7326/0003-4819-146-10-200705150-00006 17502633 · DOI
  4. [6]Choy E Marshall D Gabriel ZL Mitchell SA Gylee E Dakin HA. A systematic review and mixed treatment comparison of the efficacy of pharmacological treatments for fibromyalgia. Semin Arthr Rheum. (2011) 41: 335– 345.e6. 10.1016/j.semarthrit.2011.06.003 21868065 · DOI
  5. [7]Roskell NS Beard SM Zhao Y Le TK. A meta-analysis of pain response in the treatment of fibromyalgia. Pain Practice. (2011) 11: 516– 27. 10.1111/j.1533-2500.2010.00441.x 21199320 · DOI
  6. [8]Macfarlane GJ Kronisch C Dean LE Atzeni F Häuser W Fluß E. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis. (2017) 76: 318– 28. 10.1136/annrheumdis-2016-209724 27377815 · DOI · Paper page
  7. [9]Bidonde J Busch AJ Schachter CL Webber SC Musselman KE Overend TJ. Mixed exercise training for adults with fibromyalgia. Cochrane Database Syst Rev. (2019) 5: CD013340. 10.1002/14651858.CD013340 31124142 PMC6931522 · DOI
  8. [10]American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. 9th ed. Philadelphia, PA: Lippincott Williams & Wilkins (2014).
  9. [14]Ablin JN Amital H Ehrenfeld M Aloush V Elkayam O Langevitz P. Guidelines for the diagnosis and treatment of the fibromyalgia syndrome. Harefuah. (2013) 152: 742– 7:751, 750. 24483001
  10. [15]Häuser W Klose P Langhorst J Moradi B Steinbach M Schiltenwolf M. Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials. Arthritis Res Ther. (2010) 12: R79. 10.1186/ar3002 20459730 PMC2911859 · DOI · Paper page
  11. [16]Busch AJ Barber KAR Overend TJ Peloso PMJ Schachter CL. Exercise for treating fibromyalgia syndrome. Cochrane Database of Systematic Reviews. (2007) (4). 10.1002/14651858.CD003786.pub2 PMC12832165 17943797 · DOI
  12. [17]Andrade A Vilarino GT Serafim TT Pereira Júnior AA de Souza CA Sieczkowska SM. Modulation of Autonomic Function by Physical Exercise in Patients with Fibromyalgia Syndrome: A Systematic Review. PM R. (2019) 11: 1121– 31. 10.1002/pmrj.12158 30900831 · DOI
  13. [18]Black CD O'Connor PJ McCully KK. Increased daily physical activity and fatigue symptoms in chronic fatigue syndrome. Dyn Med. (2005) 4: 3. 10.1186/1476-5918-4-3 15745455 PMC555551 · DOI
  14. [19]Mijwel S Backman M Bolam KA Jervaeus A Sundberg CJ Margolin S. Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial. Breast Cancer Res Treat. (2018) 168: 79– 93. 10.1007/s10549-017-4571-3 29139007 PMC5847033 · DOI
  15. [20]Pavy B Iliou MC Vergès-Patois B Brion R Monpère C. Exercise, Sports and Rehabilitation Team. French Society of Cardiology guidelines for cardiac rehabilitation in adults. Arch Cardiovasc Dis. (2012) 105: 309– 28. 10.1016/j.acvd.2012.01.010 22709472 · DOI
  16. [21]Sandstad J Stensvold D Hoff M Nes BM Arbo I Bye A. The effects of high intensity interval training in women with rheumatic disease: a pilot study. Eur J Appl Physiol. (2015) 115: 2081– 9. 10.1007/s00421-015-3186-9 26013051 · DOI
  17. [22]Santen M van Bolwijn P Landewé R Verstappen F Bakker C Hidding A. High or low intensity aerobic fitness training in fibromyalgia: does it matter? J Rheum. (2002) 29: 582– 7. 11908577
  18. [23]Mannerkorpi K Nordeman L Cider Å Jonsson G. Does moderate-to-high intensity Nordic walking improve functional capacity and pain in fibromyalgia? A prospective randomized controlled trial. Arthritis Res Ther. (2010) 12: R189. 10.1186/ar3159 20942911 PMC2991024 · DOI · Paper page
  19. [24]Sveaas SH Berg IJ Fongen C Provan SA Dagfinrud H. High-intensity cardiorespiratory and strength exercises reduced emotional distress and fatigue in patients with axial spondyloarthritis: a randomized controlled pilot study. Scand J Rheum. (2018) 47: 117– 21. 10.1080/03009742.2017.1347276 28891743 · DOI
  20. [25]Thomsen RS Nilsen TIL Haugeberg G Bye A Kavanaugh A Hoff M. Impact of high-intensity interval training on disease activity and disease in patients with psoriatic arthritis: a randomized controlled trial. Arthritis Care Res. (2019) 71: 530– 7. 10.1002/acr.23614 29882634 · DOI
  21. [26]O'Leary TJ Collett J Howells K Morris MG. High but not moderate-intensity endurance training increases pain tolerance: a randomised trial. Eur J Appl Physiol. (2017) 117: 2201– 10. 10.1007/s00421-017-3708-8 28879617 · DOI
  22. [27]Saanijoki T Tuominen L Tuulari JJ Nummenmaa L Arponen E Kalliokoski K. Opioid release after high-intensity interval training in healthy human subjects. Neuropsychopharmacology. (2018) 43: 246– 54. 10.1038/npp.2017.148 28722022 PMC5729560 · DOI
  23. [28]Zubieta JK Smith YR Bueller JA Xu Y Kilbourn MR Jewett DM. Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science. (2001) 293: 311– 5. 10.1126/science.1060952 11452128 · DOI
  24. [29]Figueroa A Kingsley JD McMillan V Panton LB. Resistance exercise training improves heart rate variability in women with fibromyalgia. Clin Phys Funct Imaging. (2008) 28: 49– 54. 10.1111/j.1475-097X.2007.00776.x 18005081 · DOI
  25. [30]Bircan Ç Karasel SA Akgün B El Ö Alper S. Effects of muscle strengthening versus aerobic exercise program in fibromyalgia. Rheumatol Int. (2008) 28: 527– 32. 10.1007/s00296-007-0484-5 17982749 · DOI
  26. [31]Matsutani LA Marques AP Ferreira E a. G, Assumpção A, Lage LV, Casarotto RA, et al. Effectiveness of muscle stretching exercises with and without laser therapy at tender points for patients with fibromyalgia. Clin Exp Rheumatol. (2007) 25: 410– 5. 17631737
  27. [32]Assumpção A Matsutani LA Yuan SL Santo AS Sauer J Mango P. Muscle stretching exercises and resistance training in fibromyalgia: which is better? A three-arm randomized controlled trial. Eur J Phys Rehabil Med. (2018) 54: 663– 70. 10.23736/S1973-9087.17.04876-6 29185675 · DOI
  28. [33]Gavi MBRO Vassalo DV Amaral FT Macedo DCF Gava PL Dantas EM. Strengthening exercises improve symptoms and quality of life but do not change autonomic modulation in fibromyalgia: a randomized clinical trial. PLoS ONE. (2014) 9: 907676. 10.1371/journal.pone.0090767 24651512 PMC3961245 · DOI
  29. [34]Sañudo B Galiano D Carrasco L Blagojevic M Hoyo M de Saxton J. Aerobic Exercise Versus Combined Exercise Therapy in Women With Fibromyalgia Syndrome: A Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation. (2010) 91: 1838– 43. 10.1016/j.apmr.2010.09.006 21112423 · DOI
  30. [36]Hassett AL Gevirtz RN. Nonpharmacologic treatment for fibromyalgia: patient education, cognitive-behavioral therapy, relaxation techniques, and complementary and alternative medicine. Rheum Dis Clin North Am. (2009) 35: 393– 407. 10.1016/j.rdc.2009.05.003 19647150 PMC2743408 · DOI
  31. [39]King SJ Wessel J Bhambhani Y Sholter D Maksymowych W. The effects of exercise and education, individually or combined, in women with fibromyalgia. J Rheum. (2002) 29: 2620– 7. 12465163
  32. [40]McLoughlin MJ Colbert LH Stegner AJ Cook DB. Are women with fibromyalgia less physically active than healthy women? Med Sci Sports Exerc. (2011) 43: 905– 12. 10.1249/MSS.0b013e3181fca1ea 20881881 PMC4598051 · DOI
  33. [42]Griffin A Hauser JR. The voice of the customer. Market Sci. (1993) 12: 1– 27. 10.1287/mksc.12.1.1 · DOI
  34. [43]Cox KL Burke V Gorely TJ Beilin LJ Puddey IB. Controlled comparison of retention and adherence in home- vs center-initiated exercise interventions in women ages 40–65 years: the S.W.E.A.T. Study (Sedentary Women Exercise Adherence Trial). Prevent Med. (2003) 36: 17– 29. 10.1006/pmed.2002.1134 12473421 · DOI
  35. [44]Ramsay C Moreland J Ho M Joyce S Walker S Pullar T. An observer-blinded comparison of supervised and unsupervised aerobic exercise regimens in fibromyalgia. Rheumatology (Oxford). (2000) 39: 501– 5. 10.1093/rheumatology/39.5.501 10852980 · DOI
  36. [45]Deyle GD Allison SC Matekel RL Ryder MG Stang JM Gohdes DD. Physical therapy treatment effectiveness for osteoarthritis of the knee: a randomized comparison of supervised clinical exercise and manual therapy procedures versus a home exercise program. Phys Ther. (2005) 85: 1301– 17. 10.1093/ptj/85.12.1301 16305269 · DOI
  37. [46]Schmidt MLK Østergren P Cormie P Ragle A-M Sønksen J Midtgaard J. “Kicked out into the real world”: prostate cancer patients' experiences with transitioning from hospital-based supervised exercise to unsupervised exercise in the community. Support Care Cancer. (2019). 27: 199– 208. 10.1007/s00520-018-4306-y 29931489 · DOI
  38. [47]Dnes N Coley B Frisby K Keller A Suyom J Tsui C. “A little bit of a guidance and a little bit of group support”: a qualitative study of preferences, barriers, and facilitators to participating in community-based exercise opportunities among adults living with chronic pain. Disabil Rehab. (2020) 1− 10. 10.1080/09638288.2020.1742801 32223460 · DOI
  39. [48]Pellegrini CA Powell SM Mook N DeVivo K Ehrlich-Jones L. Use of physical activity monitors in rheumatic populations. Curr Rheumatol Rep. (2018) 20: 73. 10.1007/s11926-018-0786-5 30293147 · DOI
  40. [49]Salvat I Zaldivar P Monterde S Montull S Miralles I Castel A. Functional status, physical activity level, and exercise regularity in patients with fibromyalgia after Multidisciplinary treatment: retrospective analysis of a randomized controlled trial. Rheumatol Int. (2017) 37: 377– 87. 10.1007/s00296-016-3597-x 27844124 · DOI
  41. [50]Kop WJ Lyden A Berlin AA Ambrose K Olsen C Gracely RH. Ambulatory monitoring of physical activity and symptoms in fibromyalgia and chronic fatigue syndrome. Arthr Rheum. (2005) 52: 296– 303. 10.1002/art.20779 15641057 · DOI

Cited by

Sorted by citations

Authors
Colas, C., Goutte, J., Creac'h, C., Fontana, L., Vericel, M.-P., Manzanares, J., Peuriere, M., Akrour, M., Martin, C., Presles, E., Barth, N., Guyot, J., Garros, M., Trombert, B., Massoubre, C., Roche, F., Féasson, L., Marotte, H., Cathebras, P., & Hupin, D.
Affiliations
  • Inserm (FR)
  • Centre Hospitalier Universitaire de Saint-Étienne (FR)
  • Lyon 1 Université (FR)
  • Laboratoire Interuniversitaire de Biologie de la Motricité (FR)
Corresponding author
Colas, Claire
ORCID
Venue
Frontiers in Public Health
Publisher
Frontiers Media SA
Published
2021-05-25
Volume
9
Pages
554291-554291
ISSN
2296-2565 (ISSN-L)
DOI
10.3389/fpubh.2021.554291
PMC
PMC8185292
OpenAlex
W3165636220
Cited by
6
References
7
Citations by year
2025: 2 · 2023: 2 · 2022: 1 · 2021: 1
FWCI
0.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • HAL (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ministère des Solidarités et de la Santé
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords
fibromyalgia, physical activity, therapeutic education, supervised exercise, community-based exercise, multidisciplinary care, accelerometry, sedentary behavior, physical activity adherence, budget impact
MeSH terms
Exercise Therapy, Fibromyalgia, Humans, Quality of Life, Exercise, Randomized Controlled Trials as Topic, Intention

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review