Determining the Antimicrobial Actions of Tea Tree Oil
Open accessAbstract
Research into the mode of action of the essential oil of Melaleuca alternifolia (Tea tree oil) is briefly reviewed. Its mode of action is interpreted in terms of the membrane-toxicity of its monoterpenoid components and different approaches for determining cell membrane damage are discussed.
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Propidium iodide is a fluorescent nucleic acid stain that is unable to penetrate cell membrane structures of healthy cells.
“Propidium iodide is a fluorescent nucleic acid stain that is unable to penetrate the cell membrane structures of healthy cells.”
From In vitro antifungal activity of hydroxychavicol isolated from Piper betle L (2010) · cites this paper as [28]
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Research works printed but not linked: 11
- [1]Janssen A.M. Scheffer J.J.C. Baerheim Svendsen A. Antimicrobial activity of essential oils. A 1976-1986 literature review. Aspects of test methods Planta Medica 1986 53 395 398 10.1055/s-2006-962755 3324126 · DOI
- [3]Andrews R.E. Parks L.W. Spence K.D. Some effects of Douglas fir terpenes on certain microorganisms Appl. Environ. Microbiol. 1980 40 301 304 16345609 PMC291570
- [4]Uribe S. Ramirez J. Peña A. Effects of β-pinene on yeast membrane functions J. Bacteriol. 1985 161 1195 1200 3156123 PMC215026
- [5]Sikkema J. de Bont J.A.M. Poolman B. Mechanisms of membrane toxicity of hydrocarbons Microbiol. Rev. 1995 59 201 222 7603409 PMC239360
- [6]Cox S.D. Gustafson J.E. Mann C.M. Markham J.L. Liew Y.C. Hartland R.P. Bell H.C. Warmington J.R. Wyllie S.G. Tea tree oil causes K+ leakage and inhibits respiration in Escherichia coli Lett. Appl. Microbiol. 1998 26 355 358 10.1046/j.1472-765X.1998.00348.x 9674165 · DOI
- [7]Southwell I.A. Hayes A.J. Markham J.L. Leach D.N. The search for optimally bioactive Australian tea tree oil Acta Hort. 1993 334 265 275 10.17660/ActaHortic.1993.344.30 · DOI
- [8]Mason D.J. Dybowski R. Larrick J.W. Gant V.A. Antimicrobial action of rabbit leukocyte CAP18106-137 Antimicrob. Agents Chemother. 1997 41 624 629 9056004 PMC163762
- [9]Trumpower B.L. Gennis R.B. Energy transduction by cytochrome complexes in mitochondrial and bacterial respiration: the enzymology of coupling electron transfer reactions to transmembrane proton translocation Annu. Rev. Biochem. 1994 63 675 716 10.1146/annurev.bi.63.070194.003331 7979252 · DOI
- [10]Booth I.R. Regulation of cytoplasmic pH in bacteria Microbiol. Rev. 1985 49 359 378 3912654 PMC373043
- [11]Poolman B. Driessen A.J.M. Konings W.N. Regulation of solute transport in Streptococci by external and internal pH values Microbiol. Rev. 1987 51 498 508 3325795 PMC373129
- [13]Cox S.D. Mann C.M. Markham Bell H.C. Gustafson J.E. Warmington J.R. Wyllie S.G. The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil) J. Appl. Microbiol. 2000 88 170 175 10.1046/j.1365-2672.2000.00943.x 10735256 · DOI · Paper page
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In vitro antifungal activity of hydroxychavicol isolated from Piper betle L
Ali, I., Khan, F. G., Suri, K. A., Gupta, B. D., Satti, N. K., Dutt, P., Afrin, F., Qazi, G. N., & Khan, I. A. (2010) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/1476-0711-9-7 · Cited by 176 · see citing works
Bajpai, V. K., Han, J.-H., Rather, I. A., Park, C., Lim, J., Paek, W. K., Lee, J. S., Yoon, J.-I., & Park, Y.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02037 · Cited by 76 · see citing works
- Authors
- Cox, S. D., Mann, C. M., Markham, J. L., Gustafson, J. E., Warmington, J. R., & Wyllie, S. G.
- Affiliations
- Western Sydney University (AU)
- Genetica Biotechnologies, Bentley, Western Australia
- Corresponding author
- Cox, Sean D.
- ORCID
- Gustafson, John E.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2001-01-16
- Volume
- 6
- Issue
- 2
- Pages
- 87-91
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6236410
- OpenAlex
- W2104249814
- Cited by
- 311
- References
- 0
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 13 · 2023: 32 · 2022: 30 · 2021: 20 · 2020: 28 · 2019: 21 · 2018: 14 · 2017: 17 · 2016: 15 · 2015: 10 · 2014: 18 · 2013: 17 · 2012: 12
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- tea tree oil, Melaleuca alternifolia, essential oils, antimicrobial activity, mechanism of action, monoterpenoids, membrane toxicity, cell membrane damage
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