Cited by 183Medicinal Plant ResearchPhytochemistry and Biological ActivitiesPiperaceae Chemical and Biological Studies

Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits

Open access
Sharifi-Rad, Javad, Dey, Abhijit, Koirala, Niranjan, Shaheen, Shabnum, El Omari, Nasreddine, Salehi, Bahare, Goloshvili, Tamar, Cirone Silva, Nathália Cristina +11 more·2021·Frontiers in Pharmacology

Abstract

The genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for a long time. Different traditional healing systems have used these plants as herbal remedies to cure diverse ailments. The aim of this comprehensive and updated review is to summarize the biodiversity of the genus Cinnamomum , its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety. All the data in this review have been collected from databases and recent scientific literature including Web of Science, PubMed, ScienceDirect etc. The results showed that the bioactive compounds of Cinnamomum species possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer and neuroprotective effects. The preclinical ( in vitro / in vivo ) studies provided the possible molecular mechanisms of these action. As a novelty, recent clinical studies and toxicological data described in this paper support and confirm the pharmacological importance of the genus Cinnamomum. In conclusion, the obtained results from preclinical studies and clinical trials, as well as reduced side effects provide insights into future research of new drugs based on extracts and bioactive compounds from Cinnamomum plants.

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Research works printed but not linked: 4

  1. EUROPEAN SCIENTIFIC COOPERATIVE ON PHYTOTHERAPY (2003). ESCOP Monographs. 2nd ed. Amsterdam, Netherlands: World Press.
  2. Liao J. C. Deng J. S. Chiu C. S. Hou W. C. Huang S. S. Shie P. H. (2012b). Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo. Evid. Based Complement. Alternat Med. 2012, 429320. 10.1155/2012/429320 22536283 PMC3318905 · DOI
  3. ORGANIZATION (2001). Joint FAO/WHO Expert Committee on Food Additives. Safety evaluation of certain food additives and contaminants in food: Fumonisins. Proceedings of the 56th Meeting of the Joint FAO/WHO Expert Committee on Food Additives, 103– 279.
  4. Ravindran P. Nirmal-Babu K. Shylaja M. (2003). Cinnamon and cassia: The Genus Cinnamomum. CRC Press.

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Authors
Sharifi-Rad, J., Dey, A., Koirala, N., Shaheen, S., El Omari, N., Salehi, B., Goloshvili, T., Cirone Silva, N. C., Bouyahya, A., Vitalini, S., Varoni, E. M., Martorell, M., Abdolshahi, A., Docea, A. O., Iriti, M., Calina, D., Les, F., López, V., & Caruntu, C.
Affiliations
  • Presidency University (IN)
  • Lahore College for Women University (PK)
  • Shahid Beheshti University (IR)
  • Ilia State University (GE)
  • Mohammed V University (MA)
  • University of Milan (IT)
  • University of Concepción (CL)
  • Semnan University of Medical Sciences (IR)
  • University of Medicine and Pharmacy of Craiova (RO)
  • Universidad de Zaragoza (ES)
Corresponding author
  • Salehi, Bahare
  • Bouyahya, Abdelhakim
  • Martorell, Miquel
  • Les, Francisco
Venue
Frontiers in Pharmacology
Published
2021-05-11
Volume
12
Pages
600139-600139
ISSN
1663-9812 (ISSN-L)
OpenAlex
W3161674658
Cited by
183
References
236
Citations by year
2026: 25 · 2025: 37 · 2024: 30 · 2023: 45 · 2022: 36 · 2021: 10
FWCI
2.90
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Zaguan (University of Zaragoza Repository) (publishedVersion, other-oa)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Funders
  • Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
  • Comisión Nacional de Investigación Científica y Tecnológica (CCTE AFB170007, AFB170007)
  • Colegiul Consultativ pentru Cercetare-Dezvoltare şi Inovare
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Piperaceae Chemical and Biological Studies
Keywords
Cinnamomum, cinnamon, bioactive compounds, phytochemistry, pharmacological activity, toxicological safety, antimicrobial activity, antidiabetic activity, antioxidant activity, anti-inflammatory activity, anticancer activity, neuroprotection, molecular mechanisms, herbal medicine, spices, drug development

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