The Effect of Production and Post-Harvest Processing Practices on Quality Attributes in Centella asiatica (L.) Urban—A Review
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Centella asiatica is well known for its miraculous therapeutic properties in various systems of traditional medicine across the world. However, significant variation in its pharmacological activities has been reported due to the unavailability of quality raw material and non-standardized formulations. A number of research papers have been published on the collection of C. asiatica plants from different regions for the identification of a suitable agroclimate with elite germplasms. Efforts have been made to standardize production and post-harvest practices for the availability of quality raw material with a high centelloside content. The ecological niche modeling approach revealed that the Indian subcontinent has high climatic suitability for the production of C. asiatica, and genotypes with a high content of centelloside were predominantly found in the Western Ghats, North East, Eastern Himalaya and Western Himalaya in India. Open cultivation of C. asiatica is more suitable in these agroclimatic zones in India. Cultivation under shade is also suitable in the plains of Central India. Hydroponic and tissue culture of C. asiatica has also been successfully established for the enhanced production of centelloside using supplements and elicitors such as sucrose, auxins, cytokinins, kinetin, methyl jasmonate, etc. Freeze drying has been identified as the most efficient post-harvest method for the high pharmacological activities of C. asiatica extracts.
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Accessions of Centella asiatica from Assam, India, contained up to 21.7 mg/g asiaticoside and 11.2 mg/g madecassoside.
“while accessions from Assam, India, contained up to 21.7 mg/g asiaticoside and 11.2 mg/g madecassoside (Singh et al. 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Singh et al. 2023
Quantitative analyses have shown considerable variability in Centella asiatica phytoconstituents, with asiatic acid reported in the range 0.02-3.2%, madecassic acid 0.02-3.06%, asiaticoside 0.018-4.3%, and madecassoside 0.01-4.8%.
“have shown considerable variability in these phytoconstituents, with asiatic acid reported in the range of 0.02–3.2%, madecassic acid 0.02–3.06%, asiaticoside 0.018–4.3%, and madecassoside 0.01–4.8%”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Singh et al. 2023
Cites
Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban
James, J. T., & Dubery, I. A. (2009) · Molecules · doi:10.3390/molecules14103922 · Cited by 399 · see citing works
Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism
Kimura, Y., Sumiyoshi, M., Samukawa, K.-I., Satake, N., & Sakanaka, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.036 · Cited by 126 · see citing works
Mohandas Rao, K. G., Muddanna Rao, S., & Gurumadhva Rao, S. (2006) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/nel024 · Cited by 103 · see citing works
Incandela, L., Cesarone, M. R., Cacchio, M., De Sanctis, M. T., Santavenere, C., D'Auro, M. G., Bucci, M., & Belcaro, G. (2001) · Angiology · doi:10.1177/000331970105202s03 · Cited by 62 · see citing works
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Handayani, R., Febriyanti, R. M., Muhaimin, M., & Chearunisaa, A. Y. (2025) · Pharmacia · doi:10.3897/pharmacia.72.e167217 · Cited by 5 · see citing works
- Authors
- Singh, R., Kharsyntiew, B., Sharma, P., Sahoo, U. K., Sarangi, P. K., Prus, P., & Imbrea, F.
- Affiliations
- Mizoram University (IN)
- Indira Gandhi National Tribal University (IN)
- Central Agricultural University (IN)
- Bydgoszcz University of Science and Technology (PL)
- Univesity of Life Science "King Mihai I" from Timisoara (RO)
- Corresponding author
- Singh, Rambir
- Sahoo, Uttam Kumar
- Imbrea, Florin
- ORCID
- Venue
- Agronomy
- Publisher
- MDPI AG
- Published
- 2023-07-28
- Volume
- 13
- Issue
- 8
- Pages
- 1999
- ISSN
- 2073-4395 (ISSN-L)
- OpenAlex
- W4385342056
- Cited by
- 7
- References
- 4
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Agronomy (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- scheme “Increasing the impact of excellence research on the capacity for innovation and technology transfer within USV Timișoara (6PFE)
- University of Life Sciences “King Mihai I”, Romania (6PFE)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Agricultural and Biological Sciences › Soil Science › Plant Growth and Agriculture Techniques
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Centella asiatica, centellosides, post-harvest processing, cultivation techniques, agroclimatic suitability, ecological niche modeling, germplasm, shade cultivation, hydroponics, tissue culture, elicitors, freeze-drying, raw material quality, pharmacological activity
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