The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Integrity of the Intestinal Barrier: The Involvement of Epithelial Cells and Microbiota—A Mutual Relationship
Open accessAbstract
The gastrointestinal tract, which is constantly exposed to a multitude of stimuli, is considered responsible for maintaining the homeostasis of the host. It is inhabited by billions of microorganisms, the gut microbiota, which form a mutualistic relationship with the host. Although the microbiota is generally recognized as beneficial, at the same time, together with pathogens, they are a permanent threat to the host. Various populations of epithelial cells provide the first line of chemical and physical defense against external factors acting as the interface between luminal microorganisms and immunocompetent cells in lamina propria. In this review, we focus on some essential, innate mechanisms protecting mucosal integrity, thus responsible for maintaining intestine homeostasis. The characteristics of decisive cell populations involved in maintaining the barrier arrangement, based on mucus secretion, formation of intercellular junctions as well as production of antimicrobial peptides, responsible for shaping the gut microbiota, are presented. We emphasize the importance of cross-talk between gut microbiota and epithelial cells as a factor vital for the maintenance of the homeostasis of the GI tract. Finally, we discuss how the imbalance of these regulations leads to the compromised barrier integrity and dysbiosis considered to contribute to inflammatory disorders and metabolic diseases.
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Cites
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Cited by
Li, S., Oliva, P., Zhang, L., Goodrich, J. A., McConnell, R., Conti, D. V., Chatzi, L., & Aung, M. (2025) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-024-00742-2 · Cited by 101
Metadata
- Authors
- Gieryńska, M., Szulc-Dąbrowska, L., Struzik, J., Mielcarska, M. B., & Gregorczyk-Zboroch, K. P.
- Venue
- Animals
- Publisher
- MDPI AG
- Published
- 2022-01-08
- Volume
- 12
- Issue
- 2
- Pages
- 145
- ISSN
- 2076-2615 (ISSN-L)
- OpenAlex
- W4206188694
- Cited by
- 299
- References
- 170
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gieryńska, M., Szulc-Dąbrowska, L., Struzik, J., Mielcarska, M. B., & Gregorczyk-Zboroch, K. P. (2022). Integrity of the Intestinal Barrier: The Involvement of Epithelial Cells and Microbiota—A Mutual Relationship. Animals. https://doi.org/10.3390/ani12020145
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
