Antimicrobial Resistance and Clonal Lineages of Escherichia coli from Food-Producing Animals
Open accessAbstract
Escherichia coli are one of the most important pathogenic bacteria readily found in the livestock and widely studied as an indicator that carries drug-resistant genes between humans, animals, and the environment. The use of antimicrobials in the food chain, particularly in food-producing animals, is recognized as a significant contributor to the development and spread of antimicrobial resistance (AMR) and resistance genes can be transferred from the farm through the food-chain. The objective of this review is to highlight the background of the antimicrobials use in food-producing animals, more specifically, to study clonal lineages and the resistance profiles observed in E. coli, as well as in extended spectrum beta-lactamases (ESBL) producing E. coli, in a set of food-production animals with greater relevance in food consumption, such as pigs, poultry, cattle, fish farming and rabbits. Regarding the prevalence of ESBL-producing E. coli among farm animals, high-to-moderate prevalence was observed, and the highest resistance rates to tetracycline and ampicillin was detected in different farms in all geographic regions. Worldwide pandemic clones and high-risk zoonotic E. coli clones have been identified in most food-producing animals, and some of these clones are already disseminated in different niches, such as the environment and humans. A better understanding of the epidemiology of E. coli and ESBL-producing E. coli in livestock is urgently needed. Animal production is one of the major causes of the antibiotic resistance problem worldwide and a One Health approach is needed.
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Animal husbandry practices mainly utilize tetracyclines, penicillin, streptomycin, and ciprofloxacin as prophylaxes.
“For instance, animal husbandry practices mainly utilize tetracyclines, penicillin, streptomycin, and ciprofloxacin as prophylaxes [82,83].”
From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [83]
Section 1 (page not provided) identifies tetracyclines and penicillins as commonly used in pigs, especially for therapeutic purposes, and discusses prophylaxis as a general practice. It does not identify the four named drugs as the main prophylactic antibiotics: its mentions of streptomycin and ciprofloxacin concern bacterial resistance, not prophylactic use. (LLM, conf=0.88)
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- Authors
- Silva, A., Silva, V., Pereira, J. E., Maltez, L., Igrejas, G., Valentão, P., Falco, V., & Poeta, P.
- Affiliations
- University of Trás-os-Montes and Alto Douro (PT)
- REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal
- Corresponding author
- Poeta, Patrícia
- ORCID
- Venue
- Antibiotics
- Publisher
- MDPI AG
- Published
- 2023-06-15
- Volume
- 12
- Issue
- 6
- Pages
- 1061
- ISSN
- 2079-6382 (ISSN-L)
- PMC
- PMC10295564
- OpenAlex
- W4380992922
- Cited by
- 73
- References
- 95
- Citations by year
- 2026: 21 · 2025: 26 · 2024: 20 · 2023: 6
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antibiotics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Portuguese Foundation for Science and Technology (FCT) (UIDP/00772/2020, LA/P/0059/2020, UIDB/50006/2020, UIDP/50006/2020, SFRH/BD/04576/2020)
- FCT/MCTES (UIDP/00772/2020, LA/P/0059/2020, UIDB/50006/2020, UIDP/50006/2020, SFRH/BD/04576/2020)
- FCT (Fundacāo para a Cie^ncia e a Tecnologia) (UIDP/00772/2020, LA/P/0059/2020, UIDB/50006/2020, UIDP/50006/2020, SFRH/BD/04576/2020)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Keywords
- Escherichia coli, antimicrobial resistance, clonal lineages, extended-spectrum beta-lactamase, food-producing animals, livestock, pigs, poultry, cattle, fish farming, rabbits, tetracycline resistance, ampicillin resistance, One Health, antimicrobial use in agriculture, resistance gene transfer
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