Cited by 73Antibiotic Resistance in BacteriaEscherichia coli research studiesAntibiotic Use and Resistance

Antimicrobial Resistance and Clonal Lineages of Escherichia coli from Food-Producing Animals

Open access
Silva, Adriana, Silva, Vanessa, Pereira, José Eduardo, Maltez, Luís, Igrejas, Gilberto, Valentão, Patrícia, Falco, Virgílio, Poeta, Patrícia·2023·Antibiotics

Abstract

Escherichia coli are one of the most important pathogenic bacteria readily found in the livestock and widely studied as an indicator that carries drug-resistant genes between humans, animals, and the environment. The use of antimicrobials in the food chain, particularly in food-producing animals, is recognized as a significant contributor to the development and spread of antimicrobial resistance (AMR) and resistance genes can be transferred from the farm through the food-chain. The objective of this review is to highlight the background of the antimicrobials use in food-producing animals, more specifically, to study clonal lineages and the resistance profiles observed in E. coli, as well as in extended spectrum beta-lactamases (ESBL) producing E. coli, in a set of food-production animals with greater relevance in food consumption, such as pigs, poultry, cattle, fish farming and rabbits. Regarding the prevalence of ESBL-producing E. coli among farm animals, high-to-moderate prevalence was observed, and the highest resistance rates to tetracycline and ampicillin was detected in different farms in all geographic regions. Worldwide pandemic clones and high-risk zoonotic E. coli clones have been identified in most food-producing animals, and some of these clones are already disseminated in different niches, such as the environment and humans. A better understanding of the epidemiology of E. coli and ESBL-producing E. coli in livestock is urgently needed. Animal production is one of the major causes of the antibiotic resistance problem worldwide and a One Health approach is needed.

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Crossref · 10.3390/antibiotics12061061

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  • Animal husbandry practices mainly utilize tetracyclines, penicillin, streptomycin, and ciprofloxacin as prophylaxes.

    “For instance, animal husbandry practices mainly utilize tetracyclines, penicillin, streptomycin, and ciprofloxacin as prophylaxes [82,83].”

    From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [83]

    Section 1 (page not provided) identifies tetracyclines and penicillins as commonly used in pigs, especially for therapeutic purposes, and discusses prophylaxis as a general practice. It does not identify the four named drugs as the main prophylactic antibiotics: its mentions of streptomycin and ciprofloxacin concern bacterial resistance, not prophylactic use. (LLM, conf=0.88)

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Authors
Silva, A., Silva, V., Pereira, J. E., Maltez, L., Igrejas, G., Valentão, P., Falco, V., & Poeta, P.
Affiliations
  • University of Trás-os-Montes and Alto Douro (PT)
  • REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal
Corresponding author
Poeta, Patrícia
Venue
Antibiotics
Publisher
MDPI AG
Published
2023-06-15
Volume
12
Issue
6
Pages
1061
ISSN
2079-6382 (ISSN-L)
OpenAlex
W4380992922
Cited by
73
References
95
Citations by year
2026: 21 · 2025: 26 · 2024: 20 · 2023: 6
FWCI
1.37
Type
journal article
Language
en
Open access
Locations
  • Antibiotics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Portuguese Foundation for Science and Technology (FCT) (UIDP/00772/2020, LA/P/0059/2020, UIDB/50006/2020, UIDP/50006/2020, SFRH/BD/04576/2020)
  • FCT/MCTES (UIDP/00772/2020, LA/P/0059/2020, UIDB/50006/2020, UIDP/50006/2020, SFRH/BD/04576/2020)
  • FCT (Fundacāo para a Cie^ncia e a Tecnologia) (UIDP/00772/2020, LA/P/0059/2020, UIDB/50006/2020, UIDP/50006/2020, SFRH/BD/04576/2020)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Keywords
Escherichia coli, antimicrobial resistance, clonal lineages, extended-spectrum beta-lactamase, food-producing animals, livestock, pigs, poultry, cattle, fish farming, rabbits, tetracycline resistance, ampicillin resistance, One Health, antimicrobial use in agriculture, resistance gene transfer

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