Omics for Bioprospecting and Drug Discovery from Bacteria and Microalgae
Open accessAbstract
“Omics” represent a combinatorial approach to high-throughput analysis of biological entities for various purposes. It broadly encompasses genomics, transcriptomics, proteomics, lipidomics, and metabolomics. Bacteria and microalgae exhibit a wide range of genetic, biochemical and concomitantly, physiological variations owing to their exposure to biotic and abiotic dynamics in their ecosystem conditions. Consequently, optimal conditions for adequate growth and production of useful bacterial or microalgal metabolites are critically unpredictable. Traditional methods employ microbe isolation and ‘blind’-culture optimization with numerous chemical analyses making the bioprospecting process laborious, strenuous, and costly. Advances in the next generation sequencing (NGS) technologies have offered a platform for the pan-genomic analysis of microbes from community and strain downstream to the gene level. Changing conditions in nature or laboratory accompany epigenetic modulation, variation in gene expression, and subsequent biochemical profiles defining an organism’s inherent metabolic repertoire. Proteome and metabolome analysis could further our understanding of the molecular and biochemical attributes of the microbes under research. This review provides an overview of recent studies that have employed omics as a robust, broad-spectrum approach for screening bacteria and microalgae to exploit their potential as sources of drug leads by focusing on their genomes, secondary metabolite biosynthetic pathway genes, transcriptomes, and metabolomes. We also highlight how recent studies have combined molecular biology with analytical chemistry methods, which further underscore the need for advances in bioinformatics and chemoinformatics as vital instruments in the discovery of novel bacterial and microalgal strains as well as new drug leads.
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Multi-omics approaches allow an integrated and systems-level understanding of microalgal metabolism and stress responses.
“Multi-omics approaches, including genomics, transcriptomics, proteomics, metabolomics, and lipidomics, allow for an integrated and systems-level understanding of microalgal metabolism and stress responses [42].”
From Microalgae Bioactives for Functional Food Innovation and Health Promotion (2025) · cites this paper as [42]
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Research works printed but not linked: 1
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Microalgae Bioactives for Functional Food Innovation and Health Promotion
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“Multi-omics approaches, including genomics, transcriptomics, proteomics, metabolomics, and lipidomics, allow for an integrated and systems-level understanding of microalgal metabolism and stress responses [42].”
- Authors
- Maghembe, R., Damian, D., Makaranga, A., Nyandoro, S. S., Lyantagaye, S. L., Kusari, S., & Hatti-Kaul, R.
- Affiliations
- University of Dar es Salaam (TZ)
- International Centre for Genetic Engineering and Biotechnology (IN)
- TU Dortmund University (DE)
- Division of Biotechnology, Department of Chemistry, Center for Chemistry and Chemical Engineering, Lund University, Box 124, 22100 Lund, Sweden
- Corresponding author
- Kusari, Souvik
- ORCID
- Venue
- Antibiotics
- Publisher
- MDPI AG
- Published
- 2020-05-04
- Volume
- 9
- Issue
- 5
- Pages
- 229
- ISSN
- 2079-6382 (ISSN-L)
- PMC
- PMC7277505
- OpenAlex
- W3021586468
- Cited by
- 66
- References
- 167
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 13 · 2023: 8 · 2022: 14 · 2021: 8 · 2020: 2
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antibiotics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Styrelsen för Internationellt Utvecklingssamarbete (IMB-2015/2020)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- omics, bioprospecting, drug discovery, bacteria, microalgae, secondary metabolites, transcriptomics, proteomics, metabolomics, lipidomics, pangenomics, epigenetic modulation, gene expression, cheminformatics, bioinformatics, natural product screening
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