Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
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It is well-established that green tea supplementation has antioxidant properties. However, whether green tea supplementation leads to oxidative stress reduction remains unclear, as clinical investigations on this subject have yielded inconsistent outcomes. Consequently, we aimed to determine the effects of green tea supplementation on oxidative stress in adults. A systematic search of English language publications up to 21 August 2021 was carried out in PubMed, Scopus, Embase, and ISI Web of Science, utilizing pertinent keywords. These searches included randomized controlled trials (RCTs) evaluating the relationship between green tea supplementation, malondialdehyde (MDA), and total antioxidant capacity (TAC) in adults. A random-effects model was used to estimate the weighted mean difference (WMD) and 95% confidence intervals (95% CI). Meta-regression and non-linear dose-response analyses were performed to investigate the association between the dosage of green tea (mg/day) and the duration of the intervention (weeks) with pooled effect size. Sixteen RCTs with seventeen arms including 760 participants met the inclusion criteria. Our results indicated that green tea supplementation had significant effects on TAC (weighted mean difference [WMD]: 0.20 mmol/L; 95% CI: 0.09, 0.30, p < 0.001) and significant heterogeneity between studies (I2 = 98.6%, p < 0.001), which was largely related to gender and body mass index (BMI). Subgroup analysis in TAC identified a significant relationship except with low dose supplementation and obese individuals. No relationship between MDA and green tea supplementation was observed in any subgroups; however, meta-regression analysis revealed a linear inverse association between the dosage and significant change in MDA (r = −2117.18, p = 0.017). Our outcomes suggest that green tea supplementation improves TAC and affects MDA based on the dose of the intervention in adults. Future RCTs with longer durations are needed to expand our findings.
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While EGCG is a good antioxidant in various radical scavenging assays, in plasma its antioxidant activity is limited.
“While EGCG is a good antioxidant in various radical scavenging assays, in plasma is its antioxidant activity limited (Rasaei et al. 2021).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Rasaei et al. 2021
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Sumac ( Rhus coriaria L. ) and Human Metabolic Health: A Systematic Review and Meta‐Analysis
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- Authors
- Rasaei, N., Asbaghi, O., Samadi, M., Setayesh, L., Bagheri, R., Gholami, F., Soveid, N., Casazza, K., Wong, A., Suzuki, K., & Mirzaei, K.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- University of Isfahan (IR)
- Florida Gulf Coast University (US)
- Marymount University (US)
- Waseda University (JP)
- Corresponding author
- Suzuki, Katsuhiko
- Mirzaei, Khadijeh
- ORCID
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2021-10-29
- Volume
- 10
- Issue
- 11
- Pages
- 1731
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC8614888
- OpenAlex
- W3208283519
- Cited by
- 34
- References
- 75
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 8 · 2022: 6
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- green tea supplementation, antioxidant status, oxidative stress, malondialdehyde, total antioxidant capacity, dose-response relationship, obesity, sex differences, adults
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