Cited by 34Tea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesExercise and Physiological Responses

Effect of Green Tea Supplementation on Antioxidant Status in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

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Rasaei, Niloufar, Asbaghi, Omid, Samadi, Mahsa, Setayesh, Leila, Bagheri, Reza, Gholami, Fatemeh, Soveid, Neda, Casazza, Krista +3 more·2021·Antioxidants

Abstract

It is well-established that green tea supplementation has antioxidant properties. However, whether green tea supplementation leads to oxidative stress reduction remains unclear, as clinical investigations on this subject have yielded inconsistent outcomes. Consequently, we aimed to determine the effects of green tea supplementation on oxidative stress in adults. A systematic search of English language publications up to 21 August 2021 was carried out in PubMed, Scopus, Embase, and ISI Web of Science, utilizing pertinent keywords. These searches included randomized controlled trials (RCTs) evaluating the relationship between green tea supplementation, malondialdehyde (MDA), and total antioxidant capacity (TAC) in adults. A random-effects model was used to estimate the weighted mean difference (WMD) and 95% confidence intervals (95% CI). Meta-regression and non-linear dose-response analyses were performed to investigate the association between the dosage of green tea (mg/day) and the duration of the intervention (weeks) with pooled effect size. Sixteen RCTs with seventeen arms including 760 participants met the inclusion criteria. Our results indicated that green tea supplementation had significant effects on TAC (weighted mean difference [WMD]: 0.20 mmol/L; 95% CI: 0.09, 0.30, p < 0.001) and significant heterogeneity between studies (I2 = 98.6%, p < 0.001), which was largely related to gender and body mass index (BMI). Subgroup analysis in TAC identified a significant relationship except with low dose supplementation and obese individuals. No relationship between MDA and green tea supplementation was observed in any subgroups; however, meta-regression analysis revealed a linear inverse association between the dosage and significant change in MDA (r = −2117.18, p = 0.017). Our outcomes suggest that green tea supplementation improves TAC and affects MDA based on the dose of the intervention in adults. Future RCTs with longer durations are needed to expand our findings.

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Authors
Rasaei, N., Asbaghi, O., Samadi, M., Setayesh, L., Bagheri, R., Gholami, F., Soveid, N., Casazza, K., Wong, A., Suzuki, K., & Mirzaei, K.
Affiliations
  • Tehran University of Medical Sciences (IR)
  • Shahid Beheshti University of Medical Sciences (IR)
  • University of Isfahan (IR)
  • Florida Gulf Coast University (US)
  • Marymount University (US)
  • Waseda University (JP)
Corresponding author
  • Suzuki, Katsuhiko
  • Mirzaei, Khadijeh
Venue
Antioxidants
Publisher
MDPI AG
Published
2021-10-29
Volume
10
Issue
11
Pages
1731
ISSN
2076-3921 (ISSN-L)
OpenAlex
W3208283519
Cited by
34
References
75
Citations by year
2026: 5 · 2025: 10 · 2024: 5 · 2023: 8 · 2022: 6
FWCI
0.83
Type
journal article
Language
en
Open access
Locations
  • Antioxidants (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
green tea supplementation, antioxidant status, oxidative stress, malondialdehyde, total antioxidant capacity, dose-response relationship, obesity, sex differences, adults

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