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Cited by 18Neuroinflammation and Neurodegeneration MechanismsRedox biology and oxidative stressGlutathione Transferases and Polymorphisms

Interleukin-1β Protects Neurons against Oxidant-Induced Injury via the Promotion of Astrocyte Glutathione Production

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Chowdhury, Twinkle, Allen, Matthew F., Thorn, Trista L., He, Yan, Hewett, Sandra J.·2018·Antioxidants
DOI 10.3390/antiox7080100PMC PMC6115796
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Abstract

Interleukin-1β (IL-1β), a key cytokine that drives neuroinflammation in the Central Nervous System (CNS), is enhanced in many neurological diseases/disorders. Although IL-1β contributes to and/or sustains pathophysiological processes in the CNS, we recently demonstrated that IL-1β can protect cortical astrocytes from oxidant injury in a glutathione (GSH)-dependent manner. To test whether IL-1β could similarly protect neurons against oxidant stress, near pure neuronal cultures or mixed cortical cell cultures containing neurons and astrocytes were exposed to the organic peroxide, tert-butyl hydroperoxide (t-BOOH), following treatment with IL-1β or its vehicle. Neurons and astrocytes in mixed cultures, but not pure neurons, were significantly protected from the toxicity of t-BOOH following treatment with IL-1β in association with enhanced GSH production/release. IL-1β failed to increase the GSH levels or to provide protection against t-BOOH toxicity in chimeric mixed cultures consisting of IL-1R1+/+ neurons plated on top of IL-1R1−/− astrocytes. The attenuation of GSH release via block of multidrug resistance-associated protein 1 (MRP1) transport also abrogated the protective effect of IL-1β. These protective effects were not strictly an in vitro phenomenon as we found an increased striatal vulnerability to 3-nitropropionic acid-mediated oxidative stress in IL-1R1 null mice. Overall, our data indicate that IL-1β protects neurons against oxidant injury and that this likely occurs in a non-cell-autonomous manner that relies on an increase in astrocyte GSH production and release.

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  • Improved supply of GSH precursors from astrocytes to neurons and a thereby better resistance of neurons has been reported after β-adrenergic stimulation, by exposure to interleukin 1β, or after exposure to ethanol.

    “Interestingly, improved supply of GSH precursors from astrocytes to neurons and a thereby better resistance of neurons has been reported after β‐adrenergic stimulation (Yoshioka et al. 2021), by exposure to interleukin 1β (Chowdhury et al. 2018) or after exposure to ethanol (Rathinam et al. 2006).”

    From Glutathione Metabolism of the Brain—The Role of Astrocytes (2025) · cites this paper as Chowdhury et al. 2018

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  1. [1]Ross F.M. Allan S.M. Rothwell N.J. Verkhratsky A. A dual role for interleukin-1 in LTP in mouse hippocampal slices J. Neuroimmunol. 2003 144 61 67 10.1016/j.jneuroim.2003.08.030 14597099 · DOI
  2. [2]Schneider H. Pitossi F. Balschun D. Wagner A. del Rey A. Besedovsky H.O. A neuromodulatory role of interleukin-1β in the hippocampus Proc. Natl. Acad. Sci. USA 1998 95 7778 7783 10.1073/pnas.95.13.7778 9636227 PMC22755 · DOI · Paper page
  3. [3]Avital A. Goshen I. Kamsler A. Segal M. Iverfeldt K. Richter-Levin G. Yirmiya R. Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity Hippocampus 2003 13 826 834 10.1002/hipo.10135 14620878 · DOI
  4. [4]Fang J. Wang Y. Krueger J.M. Effects of interleukin-1 beta on sleep are mediated by the type I receptor Am. J. Physiol. 1998 274 R655 R660 9530230
  5. [5]Krueger J.M. Fang J. Taishi P. Chen Z. Kushikata T. Gardi J. Sleep. A physiologic role for IL-1 beta and TNF-alpha Ann. N. Y. Acad. Sci. 1998 856 148 159 10.1111/j.1749-6632.1998.tb08323.x 9917875 · DOI
  6. [7]Hewett S.J. Jackman N.A. Claycomb R.J. Interleukin-1β in central nervous system injury and repair Eur. J. Neurodegener. Dis. 2012 1 195 211 26082912 PMC4465544
  7. [8]Jackman N.A. Uliasz T.F. Hewett J.A. Hewett S.J. Regulation of system xc− activity and expression in astrocytes by interleukin-1beta: Implications for hypoxic neuronal injury Glia 2010 58 1806 1815 10.1002/glia.21050 20645408 PMC4451603 · DOI
  8. [9]Fogal B. Li J. Lobner D. McCullough L.D. Hewett S.J. System xc− activity and astrocytes are necessary for interleukin-1beta-mediated hypoxic neuronal injury J. Neurosci. 2007 27 10094 10105 10.1523/JNEUROSCI.2459-07.2007 17881516 PMC6672668 · DOI
  9. [10]Fogal B. Hewett J.A. Hewett S.J. Interleukin-1beta potentiates neuronal injury in a variety of injury models involving energy deprivation J. Neuroimmunol. 2005 161 93 100 10.1016/j.jneuroim.2004.12.007 15748948 · DOI
  10. [11]Jackman N.A. Melchior S.E. Hewett J.A. Hewett S.J. Non-cell autonomous influence of the astrocyte system xc− on hypoglycaemic neuronal cell death ASN Neuro 2012 4 e00074 10.1042/AN20110030 22220511 PMC3275339 · DOI
  11. [12]He Y. Jackman N.A. Thorn T.L. Vought V.E. Hewett S.J. Interleukin-1beta protects astrocytes against oxidant-induced injury via an nf-kappab-dependent upregulation of glutathione synthesis Glia 2015 63 1568 1580 10.1002/glia.22828 25880604 PMC4506211 · DOI
  12. [13]Glaccum M.B. Stocking K.L. Charrier K. Smith J.L. Willis C.R. Maliszewski C. Livingston D.J. Peschon J.J. Morrissey P.J. Phenotypic and functional characterization of mice that lack the type I receptor for IL-1 J. Immunol. 1997 159 3364 3371 9317135
  13. [14]Hamby M.E. Uliasz T.F. Hewett S.J. Hewett J.A. Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytes J. Neurosci. Methods 2006 150 128 137 10.1016/j.jneumeth.2005.06.016 16105687 · DOI
  14. [15]Trackey J.L. Uliasz T.F. Hewett S.J. Sin-1-induced cytotoxicity in mixed cortical cell culture: Peroxynitrite-dependent and -independent induction of excitotoxic cell death J. Neurochem. 2001 79 445 455 10.1046/j.1471-4159.2001.00584.x 11677273 · DOI
  15. [16]Dringen R. Kussmaul L. Hamprecht B. Rapid clearance of tertiary butyl hydroperoxide by cultured astroglial cells via oxidation of glutathione Glia 1998 23 139 145 10.1002/(SICI)1098-1136(199806)23:2<139::AID-GLIA5>3.0.CO;2-1 9600382 · DOI
  16. [17]Hirrlinger J. Schulz J.B. Dringen R. Glutathione release from cultured brain cells: Multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells J. Neurosci. Res. 2002 69 318 326 10.1002/jnr.10308 12125073 · DOI
  17. [18]Borlongan C.V. Koutouzis T.K. Freeman T.B. Cahill D.W. Sanberg P.R. Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of huntington’s disease Brain Res. 1995 697 254 257 10.1016/0006-8993(95)00901-2 8593585 · DOI
  18. [19]Schulz J.B. Henshaw D.R. MacGarvey U. Beal M.F. Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity Neurochem. Int. 1996 29 167 171 10.1016/0197-0186(95)00122-0 8837046 · DOI
  19. [20]Uliasz T.F. Hewett S.J. A microtiter trypan blue absorbance assay for the quantitative determination of excitotoxic neuronal injury in cell culture J. Neurosci. Methods 2000 100 157 163 10.1016/S0165-0270(00)00248-X 11040379 · DOI
  20. [21]Lobner D. Comparison of the LDH and mtt assays for quantifying cell death: Validity for neuronal apoptosis? J. Neurosci. Methods 2000 96 147 152 10.1016/S0165-0270(99)00193-4 10720679 · DOI
  21. [22]He Y. Akumuo R.C. Yang Y. Hewett S.J. Mice deficient in l-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity Neurosci. Lett. 2017 643 65 69 10.1016/j.neulet.2017.02.031 28229935 PMC5383203 · DOI
  22. [24]Wang J. Bankiewicz K.S. Plunkett R.J. Oldfield E.H. Intrastriatal implantation of interleukin-1. Reduction of parkinsonism in rats by enhancing neuronal sprouting from residual dopaminergic neurons in the ventral tegmental area of the midbrain J. Neurosurg. 1994 80 484 490 10.3171/jns.1994.80.3.0484 7906726 · DOI
  23. [25]Fagan A.M. Gage F.H. Cholinergic sprouting in the hippocampus: A proposed role for IL-1 Exp. Neurol. 1990 110 105 120 10.1016/0014-4886(90)90055-W 1698653 · DOI
  24. [26]Temporin K. Tanaka H. Kuroda Y. Okada K. Yachi K. Moritomo H. Murase T. Yoshikawa H. IL-1beta promotes neurite outgrowth by deactivating RhoA via p38 mapk pathway Biochem. Biophys. Res. Commun. 2008 365 375 380 10.1016/j.bbrc.2007.10.198 17996195 · DOI
  25. [27]Ohtsuki T. Ruetzler C.A. Tasaki K. Hallenbeck J.M. Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neurons J. Cereb. Blood Flow Metab. 1996 16 1137 1142 10.1097/00004647-199611000-00007 8898685 · DOI
  26. [28]Pringle A.K. Niyadurupola N. Johns P. Anthony D.C. Iannotti F. Interleukin-1beta exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures Neurosci. Lett. 2001 305 29 32 10.1016/S0304-3940(01)01795-5 11356300 · DOI
  27. [30]Strijbos P.J. Rothwell N.J. Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: Involvement of nerve growth factor J. Neurosci. 1995 15 3468 3474 10.1523/JNEUROSCI.15-05-03468.1995 7538561 PMC6578191 · DOI
  28. [32]Moore A.H. Wu M. Shaftel S.S. Graham K.A. O’Banion M.K. Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory Neuroscience 2009 164 1484 1495 10.1016/j.neuroscience.2009.08.073 19744544 PMC2783232 · DOI
  29. [33]Matousek S.B. Hein A.M. Shaftel S.S. Olschowka J.A. Kyrkanides S. O’Banion M.K. Cyclooxygenase-1 mediates prostaglandin E2 elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression J. Neurochem. 2010 114 247 258 20412387 PMC2897946
  30. [34]Hassel B. Sonnewald U. Selective inhibition of the tricarboxylic acid cycle of gabaergic neurons with 3-nitropropionic acid in vivo J. Neurochem. 1995 65 1184 1191 10.1046/j.1471-4159.1995.65031184.x 7643096 · DOI
  31. [35]Brouillet E. Conde F. Beal M.F. Hantraye P. Replicating huntington’s disease phenotype in experimental animals Prog. Neurobiol. 1999 59 427 468 10.1016/S0301-0082(99)00005-2 10515664 · DOI
  32. [36]Beal M.F. Brouillet E. Jenkins B.G. Ferrante R.J. Kowall N.W. Miller J.M. Storey E. Srivastava R. Rosen B.R. Hyman B.T. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid J. Neurosci. 1993 13 4181 4192 10.1523/JNEUROSCI.13-10-04181.1993 7692009 PMC6576392 · DOI
  33. [37]Brouillet E. Jacquard C. Bizat N. Blum D. 3-nitropropionic acid: A mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in huntington’s disease J. Neurochem. 2005 95 1521 1540 10.1111/j.1471-4159.2005.03515.x 16300642 · DOI
  34. [38]Palfi S. Ferrante R.J. Brouillet E. Beal M.F. Dolan R. Guyot M.C. Peschanski M. Hantraye P. Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of huntington’s disease J. Neurosci. 1996 16 3019 3025 10.1523/JNEUROSCI.16-09-03019.1996 8622131 PMC6579050 · DOI
  35. [39]Reynolds D.S. Carter R.J. Morton A.J. Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of huntington’s disease J. Neurosci. 1998 18 10116 10127 10.1523/JNEUROSCI.18-23-10116.1998 9822765 PMC6793275 · DOI
  36. [40]Beal M.F. Aging, energy, and oxidative stress in neurodegenerative diseases Ann. Neurol. 1995 38 357 366 10.1002/ana.410380304 7668820 · DOI
  37. [41]Ban E.M. Interleukin-1 receptors in the brain: Characterization by quantitative in situ autoradiography Immunomethods 1994 5 31 40 10.1006/immu.1994.1035 7842248 · DOI
  38. [42]Ban E.M. Sarlieve L.L. Haour F.G. Interleukin-1 binding sites on astrocytes Neuroscience 1993 52 725 733 10.1016/0306-4522(93)90421-B 8450969 · DOI
  39. [43]Choi S. Friedman W.J. Inflammatory cytokines IL-1beta and TNF-alpha regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms ASN Neuro 2009 1 e00010 10.1042/AN20090009 19570027 PMC2695582 · DOI
  40. [44]Friedman W.J. Cytokines regulate expression of the type 1 interleukin-1 receptor in rat hippocampal neurons and glia Exp. Neurol. 2001 168 23 31 10.1006/exnr.2000.7595 11170718 · DOI
  41. [45]Tomozawa Y. Inoue T. Satoh M. Expression of type I interleukin-1 receptor mrna and its regulation in cultured astrocytes Neurosci. Lett. 1995 195 57 60 10.1016/0304-3940(95)11781-Q 7478255 · DOI
  42. [46]Srinivasan D. Yen J.H. Joseph D.J. Friedman W. Cell type-specific interleukin-1beta signaling in the CNS J. Neurosci. 2004 24 6482 6488 10.1523/JNEUROSCI.5712-03.2004 15269258 PMC6729878 · DOI
  43. [47]Sagara J.I. Miura K. Bannai S. Maintenance of neuronal glutathione by glial cells J. Neurochem. 1993 61 1672 1676 10.1111/j.1471-4159.1993.tb09802.x 8228986 · DOI
  44. [48]Sun X. Shih A.Y. Johannssen H.C. Erb H. Li P. Murphy T.H. Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface J. Biol. Chem. 2006 281 17420 17431 10.1074/jbc.M601567200 16624809 · DOI
  45. [49]Shih A.Y. Johnson D.A. Wong G. Kraft A.D. Jiang L. Erb H. Johnson J.A. Murphy T.H. Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress J. Neurosci. 2003 23 3394 3406 10.1523/JNEUROSCI.23-08-03394.2003 12716947 PMC6742304 · DOI
  46. [50]Keelan J. Allen N.J. Antcliffe D. Pal S. Duchen M.R. Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane J. Neurosci. Res. 2001 66 873 884 10.1002/jnr.10085 11746414 · DOI
  47. [51]Raps S.P. Lai J.C. Hertz L. Cooper A.J. Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons Brain Res. 1989 493 398 401 10.1016/0006-8993(89)91178-5 2765907 · DOI
  48. [52]Jakel R.J. Townsend J.A. Kraft A.D. Johnson J.A. Nrf2-mediated protection against 6-hydroxydopamine Brain Res. 2007 1144 192 201 10.1016/j.brainres.2007.01.131 17336276 PMC2062573 · DOI
  49. [53]Tanaka J. Toku K. Zhang B. Ishihara K. Sakanaka M. Maeda N. Astrocytes protect neuronal death induced by reactive oxygen and nitrogen species Glia 1999 28 85 96 10.1002/(SICI)1098-1136(199911)28:2<85::AID-GLIA1>3.0.CO;2-Y 10533053 · DOI
  50. [54]Desagher S. Glowinski J. Premont J. Astrocytes protect neurons from hydrogen peroxide toxicity J. Neurosci. 1996 16 2553 2562 10.1523/JNEUROSCI.16-08-02553.1996 8786431 PMC6578753 · DOI
  51. [55]Makar T.K. Nedergaard M. Preuss A. Gelbard A.S. Perumal A.S. Cooper A.J. Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: Evidence that astrocytes play an important role in antioxidative processes in the brain J. Neurochem. 1994 62 45 53 10.1046/j.1471-4159.1994.62010045.x 7903354 · DOI
  52. [56]Gegg M.E. Clark J.B. Heales S.J.R. Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligase activity Brain Res. 2005 1036 1 6 10.1016/j.brainres.2004.11.064 15725395 · DOI
  53. [57]Drukarch B. Schepens E. Jongenelen C.A.M. Stoof J.C. Langeveld C.H. Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiency Brain Res. 1997 770 123 130 10.1016/S0006-8993(97)00790-7 9372211 · DOI
  54. [58]Abramov A.Y. Canevari L. Duchen M.R. Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity J. Neurosci. 2003 23 5088 5095 10.1523/JNEUROSCI.23-12-05088.2003 12832532 PMC6741151 · DOI · Paper page
  55. [59]Shi J. He Y. Hewett S.J. Hewett J.A. Interleukin 1beta regulation of the system xc− substrate-specific subunit, xCT, in primary mouse astrocytes involves the RNA-binding protein HuR J. Biol. Chem. 2016 291 1643 1651 10.1074/jbc.M115.697821 26601945 PMC4722447 · DOI
  56. [60]Dringen R. Gutterer J.M. Hirrlinger J. Glutathione metabolism in brain. Metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species Eur. J. Biochem. 2000 267 4912 4916 10.1046/j.1432-1327.2000.01597.x 10931173 · DOI
  57. [61]Dringen R. Pfeiffer B. Hamprecht B. Synthesis of the antioxidant glutathione in neurons: Supply by astrocytes of CysGly as precursor for neuronal glutathione J. Neurosci. 1999 19 562 569 10.1523/JNEUROSCI.19-02-00562.1999 9880576 PMC6782200 · DOI · Paper page
  58. [62]Schulz J.B. Lindenau J. Seyfried J. Dichgans J. Glutathione, oxidative stress and neurodegeneration Eur. J. Biochem. 2000 267 4904 4911 10.1046/j.1432-1327.2000.01595.x 10931172 · DOI
  59. [63]Kranich O. Hamprecht B. Dringen R. Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain Neurosci. Lett. 1996 219 211 214 10.1016/S0304-3940(96)13217-1 8971817 · DOI · Paper page
  60. [64]Stridh M.H. Tranberg M. Weber S.G. Blomstrand F. Sandberg M. Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: Likely involvement of connexin hemichannels J. Biol. Chem. 2008 283 10347 10356 10.1074/jbc.M704153200 18272524 PMC2447665 · DOI
  61. [65]Rana S. Dringen R. Gap junction hemichannel-mediated release of glutathione from cultured rat astrocytes Neurosci. Lett. 2007 415 45 48 10.1016/j.neulet.2006.12.043 17222973 · DOI
  62. [66]Hanigan M.H. Ricketts W.A. Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase Biochemistry 1993 32 6302 6306 10.1021/bi00075a026 8099811 · DOI
  63. [67]Olson C.K. Binkley F. Metabolism of glutathione. III. Enzymatic hydrolysis of cysteinylglycine J. Biol. Chem. 1950 186 731 735 14794668
  64. [68]Dringen R. Gutterer J.M. Gros C. Hirrlinger J. Aminopeptidase n mediates the utilization of the GSH precursor CysGly by cultured neurons J. Neurosci. Res. 2001 66 1003 1008 10.1002/jnr.10042 11746430 · DOI · Paper page
  65. [69]Babior B.M. Oxygen-dependent microbial killing by phagocytes (second of two parts) N. Engl. J. Med. 1978 298 721 725 10.1056/NEJM197803302981305 203852 · DOI
  66. [70]Babior B.M. Oxygen-dependent microbial killing by phagocytes (first of two parts) N. Engl. J. Med. 1978 298 659 668 10.1056/NEJM197803232981205 24176 · DOI
  67. [71]Carreras M.C. Pargament G.A. Catz S.D. Poderoso J.J. Boveris A. Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils FEBS Lett. 1994 341 65 68 10.1016/0014-5793(94)80241-6 8137924 · DOI
  68. [72]Zhang P. Hatter A. Liu B. Manganese chloride stimulates rat microglia to release hydrogen peroxide Toxicol. Lett. 2007 173 88 100 10.1016/j.toxlet.2007.06.013 17669604 PMC2100035 · DOI
  69. [73]Banati R.B. Gehrmann J. Schubert P. Kreutzberg G.W. Cytotoxicity of microglia Glia 1993 7 111 118 10.1002/glia.440070117 8423058 · DOI
  70. [74]Henzler T. Steudle E. Transport and metabolic degradation of hydrogen peroxide in chara corallina: Model calculations and measurements with the pressure probe suggest transport of H2O2 across water channels J. Exp. Bot. 2000 51 2053 2066 10.1093/jexbot/51.353.2053 11141179 · DOI
  71. [75]Badaut J. Lasbennes F. Magistretti P.J. Regli L. Aquaporins in brain: Distribution, physiology, and pathophysiology J. Cereb. Blood Flow Metab. 2002 22 367 378 10.1097/00004647-200204000-00001 11919508 · DOI
  72. [76]Badaut J. Fukuda A.M. Jullienne A. Petry K.G. Aquaporin and brain diseases Biochim. Biophys. Acta 2014 1840 1554 1565 10.1016/j.bbagen.2013.10.032 24513456 PMC3960327 · DOI
  73. [77]Sato H. Tamba M. Ishii T. Bannai S. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins J. Biol. Chem. 1999 274 11455 11458 10.1074/jbc.274.17.11455 10206947 · DOI
  74. [78]Bassi M.T. Gasol E. Manzoni M. Pineda M. Riboni M. Martin R. Zorzano A. Borsani G. Palacin M. Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc Pflugers Archiv Eur. J. Physiol. 2001 442 286 296 10.1007/s004240100537 11417227 · DOI
  75. [79]Bridges C.C. Kekuda R. Wang H. Prasad P.D. Mehta P. Huang W. Smith S.B. Ganapathy V. Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells Investig. Ophthalmol. Vis. Sci. 2001 42 47 54 11133847
  76. [80]Deneke S.M. Fanburg B.L. Regulation of cellular glutathione Am. J. Physiol. 1989 257 L163 L173 10.1152/ajplung.1989.257.4.L163 2572174 · DOI
  77. [81]Gennuso F. Fernetti C. Tirolo C. Testa N. L’Episcopo F. Caniglia S. Morale M.C. Ostrow J.D. Pascolo L. Tiribelli C. Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1) Proc. Natl. Acad. Sci. USA 2004 101 2470 2475 10.1073/pnas.0308452100 14983033 PMC356974 · DOI
  78. [82]Ye B. Shen H. Zhang J. Zhu Y.G. Ransom B.R. Chen X.C. Ye Z.C. Dual pathways mediate beta-amyloid stimulated glutathione release from astrocytes Glia 2015 63 2208 2219 10.1002/glia.22886 26200696 · DOI
  79. [83]Ballatori N. Hammond C.L. Cunningham J.B. Krance S.M. Marchan R. Molecular mechanisms of reduced glutathione transport: Role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins Toxicol. Appl. Pharmacol. 2005 204 238 255 10.1016/j.taap.2004.09.008 15845416 · DOI
  80. [84]Becher B. Spath S. Goverman J. Cytokine networks in neuroinflammation Nat. Rev. Immunol. 2017 17 49 59 10.1038/nri.2016.123 27916979 · DOI

Cited by

Sorted by citations

Authors
Chowdhury, T., Allen, M. F., Thorn, T. L., He, Y., & Hewett, S. J.
Affiliations
Syracuse University (US)
Corresponding author
Hewett, Sandra J.
ORCID
Venue
Antioxidants
Publisher
MDPI AG
Published
2018-07-25
Volume
7
Issue
8
Pages
100
ISSN
2076-3921 (ISSN-L)
DOI
10.3390/antiox7080100
PMC
PMC6115796
OpenAlex
W2883429937
Cited by
18
References
4
Citations by year
2026: 2 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 1
FWCI
1.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Antioxidants (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (5R01NS051445- 08)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
Keywords
IL-1β, glutathione, astrocytes, neurons, oxidant injury, tert-butyl hydroperoxide, oxidative stress, neuroprotection, IL-1 receptor 1, MRP1, astrocyte-neuron interaction, 3-nitropropionic acid, striatum, neuroinflammation

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