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Cited by 106Redox biology and oxidative stressPlant Stress Responses and ToleranceNitrogen and Sulfur Effects on Brassica

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Physiological Roles of Plant Methionine Sulfoxide Reductases in Redox Homeostasis and Signaling

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Rey, Pascal, Tarrago, Lionel·2018·Antioxidants
DOI 10.3390/antiox7090114PMC PMC6162775
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Abstract

Oxidation of methionine (Met) leads to the formation of two S- and R-diastereoisomers of Met sulfoxide (MetO) that are reduced back to Met by methionine sulfoxide reductases (MSRs), A and B, respectively. Here, we review the current knowledge about the physiological functions of plant MSRs in relation with subcellular and tissue distribution, expression patterns, mutant phenotypes, and possible targets. The data gained from modified lines of plant models and crop species indicate that MSRs play protective roles upon abiotic and biotic environmental constraints. They also participate in the control of the ageing process, as shown in seeds subjected to adverse conditions. Significant advances were achieved towards understanding how MSRs could fulfil these functions via the identification of partners among Met-rich or MetO-containing proteins, notably by using redox proteomic approaches. In addition to a global protective role against oxidative damage in proteins, plant MSRs could specifically preserve the activity of stress responsive effectors such as glutathione-S-transferases and chaperones. Moreover, several lines of evidence indicate that MSRs fulfil key signaling roles via interplays with Ca2+- and phosphorylation-dependent cascades, thus transmitting ROS-related information in transduction pathways.

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Crossref · 10.3390/antiox7090114

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Figure 1 Reducing pathways of plant methionine sulfoxide reductases (MSRs). Methionine (Met) can be oxidized into Met sulfoxide and met sulfone, the latter modification being irreversible. Two main paths supply electrons to MSRs that allow Met regeneration from Met sulfoxide (MetO): on one hand, the path from photosynthetic electron chain to thioredoxins that takes place in chloroplast, and on the other hand, the one from reduced nicotinamide adenine dinucleotide phosphate (NADPH) to thioredoxin that is localized in cytosol. Other routes, involving notably glutaredoxins, participate in the reduction of atypical MSRs harboring for example one unique catalytic cysteine, in chloroplast. ROS: reactive oxygen species.
Figure 1 Reducing pathways of plant methionine sulfoxide reductases (MSRs). Methionine (Met) can be oxidized into Met sulfoxide and met sulfone, the latter modification being irreversible. Two main paths supply electrons to MSRs that allow Met regeneration from Met sulfoxide (MetO): on one hand, the path from photosynthetic electron chain to thioredoxins that takes place in chloroplast, and on the other hand, the one from reduced nicotinamide adenine dinucleotide phosphate (NADPH) to thioredoxin that is localized in cytosol. Other routes, involving notably glutaredoxins, participate in the reduction of atypical MSRs harboring for example one unique catalytic cysteine, in chloroplast. ROS: reactive oxygen species.CC BY · PubMed Central
Figure 2 Subcellular localization of MSRs in Arabidopsis thaliana. Localization of MSRA4, MSRB1, and MSRB2 in plastid, of MSRB3 in endoplasmic reticulum and of MSRB7 and MSRB8 was proven experimentally [49,50,51,52]. These isoforms appear in black. For other isoforms (in white), the localization is based on predictions from sequence analysis or on proteomic analyses [63,64,65].
Figure 2 Subcellular localization of MSRs in Arabidopsis thaliana. Localization of MSRA4, MSRB1, and MSRB2 in plastid, of MSRB3 in endoplasmic reticulum and of MSRB7 and MSRB8 was proven experimentally [49,50,51,52]. These isoforms appear in black. For other isoforms (in white), the localization is based on predictions from sequence analysis or on proteomic analyses [63,64,65].CC BY · PubMed Central
Figure 3 Physiological functions of plant MSRs. The functions of MSRs in the responses to high light, high salt, high carbonate, water deficit, low temperature, cadmium and in photoperiod adaptation was shown in Arabidopsis [50,52,76,105,107,112,113] rice, [55,57,114] or Glycine soja [60]. The participation in responses to biotic constraints was reported in Arabidopsis [86], pepper, or tomato [56] the involvement in seed ageing in Arabidopsis and Medicago truncatula [68]. The presumed role in organ senescence and fruit maturation is based on expression patterns and identification of possible partners in Aarabidopsis, strawberry, litchi, and banana [50,61,62,71].
Figure 3 Physiological functions of plant MSRs. The functions of MSRs in the responses to high light, high salt, high carbonate, water deficit, low temperature, cadmium and in photoperiod adaptation was shown in Arabidopsis [50,52,76,105,107,112,113] rice, [55,57,114] or Glycine soja [60]. The participation in responses to biotic constraints was reported in Arabidopsis [86], pepper, or tomato [56] the involvement in seed ageing in Arabidopsis and Medicago truncatula [68]. The presumed role in organ senescence and fruit maturation is based on expression patterns and identification of possible partners in Aarabidopsis, strawberry, litchi, and banana [50,61,62,71].CC BY · PubMed Central
Figure 4 Presumed modes of action of plant MSRs. The proposed functions of MSRs in repair and preservation of antioxidant, protein processing, and photosynthetic systems and in signaling transduction pathways are based on the phenotype of plants modified for MSR expression and on the identity of their possible targets.
Figure 4 Presumed modes of action of plant MSRs. The proposed functions of MSRs in repair and preservation of antioxidant, protein processing, and photosynthetic systems and in signaling transduction pathways are based on the phenotype of plants modified for MSR expression and on the identity of their possible targets.CC BY · PubMed Central

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Metadata

Authors
Rey, P., & Tarrago, L.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Rey, Pascal
ORCID
Venue
Antioxidants
Publisher
MDPI AG
Published
2018-08-29
Volume
7
Issue
9
Pages
114
ISSN
2076-3921 (ISSN-L)
DOI
10.3390/antiox7090114
PMC
PMC6162775
OpenAlex
W2889182229
Cited by
102
References
142
Citations by year
2026: 13 · 2025: 8 · 2024: 16 · 2023: 9 · 2022: 14 · 2021: 18 · 2020: 14 · 2019: 8 · 2018: 1
FWCI
1.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Antioxidants (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • HAL Portal Artxiker (Hindustan Aeronautics Limited (India)) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Nitrogen and Sulfur Effects on Brassica
Keywords
methionine sulfoxide reductase, methionine sulfoxide, redox homeostasis, redox signaling, plant stress response, protein oxidation, seed deterioration, glutathione S-transferase, molecular chaperones, calcium signaling, phosphorylation, reactive oxygen species, redox proteomics, abiotic stress, biotic stress, plant mutants

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