The DOI matches its Crossref record; 146 of the 156 references it cites were found in a registry or an index.
Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview
Open accessAbstract
Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing effects on many human common diseases, such as cancer, cardiovascular and metabolic disorders, blood pressure, and diabetes, through its antioxidant, anti-inflammatory, and lipid-lowering properties, as demonstrated in several in vitro, in vivo, and clinical studies. The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases. Among the 83 human interventional trials considered, the consumption of garlic has been reported to modulate multiple biomarkers of different diseases; in addition, its combination with drugs or other food matrices has been shown to be safe and to prolong their therapeutic effects. The rapid metabolism and poor bioavailability that have limited the therapeutic use of garlic in the last years are also discussed.
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“Mainly contained in onion and garlic, they have shown to exert beneficial effects against cardiovascular diseases, cancer, aging, inflammation, OS, and infection, among the others [202,203].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [202]
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“Alliin, allicin, allyl sulphides, allylcysteines and other sulphur-containing compounds have long been known for their antioxidant properties [202].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [202]
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1 retracted
Aalami-Harandi, R., Karamali, M., & Asemi, Z. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.977248 · Cited by 49
RetractedGlobal aetiology and epidemiology of type 2 diabetes mellitus and its complications
Zheng, Y., Ley, S. H., & Hu, F. B. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.151 · Cited by 5,697
Cancer treatment and survivorship statistics, 2019
Miller, K. D., Nogueira, L., Mariotto, A. B., Rowland, J. H., Yabroff, K. R., Alfano, C. M., Jemal, A., Kramer, J. L., & Siegel, R. L. (2019) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21565 · Cited by 4,366
Siti, H. N., Kamisah, Y., & Jaarin, K. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.03.005 · Cited by 925
Samson, S. L., & Garber, A. J. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.009 · Cited by 828
Ma, J.-L., Zhang, L., Brown, L. M., Li, W., Shen, L., Pan, K., Liu, W., Hu, Y., Han, Z.-X., Crystal-Mansour, S., et al. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs003 · Cited by 460
You, W., Brown, L. M., Zhang, L., Li, J., Jin, M., Chang, Y.-S., Ma, J., Pan, K., Liu, W., Hu, Y., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj264 · Cited by 443
Effect of Garlic on Total Serum Cholesterol
Warshafsky, S., Kamer, R. S., & Sivak, S. L. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-7_part_1-199310010-00009 · Cited by 372
Health Benefits of Culinary Herbs and Spices
Jiang, T. A. (2019) · Journal of AOAC International · doi:10.5740/jaoacint.18-0418 · Cited by 353
A meta-analysis of the effect of garlic on blood pressure
Silagy, C., & Neil, H. A. W. (1994) · Journal of Hypertension · doi:10.1097/00004872-199404000-00017 · Cited by 340
Flagged first, then by citations
10 of the 156 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Londhe, 2011, Role of garlic (Allium sativum) in various diseases: An overview, Angiogenesis, 12, 13
- Varma, 2011, Potential clinical benefits of garlic (Allium sativum), J. Environ. Res. Dev., 5, 652
Cited by
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Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials
Parham, S., Kharazi, A. Z., Bakhsheshi‐Rad, H. R., Nur, H., Ismail, A. F., Sharif, S., Ramakrishna, S., & Berto, F. (2020) · Antioxidants · doi:10.3390/antiox9121309 · Cited by 535
Anticancer potential of garlic and its bioactive constituents: A systematic and comprehensive review
Greef, D. D., Barton, E. M., Sandberg, E. N., Croley, C. R., Pumarol, J., Wong, T. L., Das, N., & Bishayee, A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.020 · Cited by 170
Association between Oral Cancer and Diet: An Update
Rodríguez-Molinero, J., Migueláñez-Medrán, B. D. C., Puente-Gutiérrez, C., Delgado-Somolinos, E., Carreras‐Presas, C. M., Fernández-Farhall, J., & López‐Sánchez, A. F. (2021) · Nutrients · doi:10.3390/nu13041299 · Cited by 171
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145
The role of natural antioxidants in cisplatin-induced hepatotoxicity
Rashid, N. A., Halim, S. A. S. A., Teoh, S. L., Budin, S. B., Hussan, F., Ridzuan, N. R. A., & Jalil, N. A. A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112328 · Cited by 147
Metadata
- Authors
- Ansary, J., Forbes-Hernández, T. Y., Gil, E., Cianciosi, D., Zhang, J., Elexpuru-Zabaleta, M., Simal-Gandara, J., Giampieri, F., & Battino, M.
- Affiliations
- Marche Polytechnic University (IT)
- Universidade de Vigo (ES)
- Nutrition and Food Science Group, Department of Biochemistry, Genetics and Immunology, Faculty of Biology, University of Vigo, 36310 Vigo, Spain
- Dipartimento di Scienze Cliniche e Molecolari, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy
- Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Science, University of Vigo, Ourense Campus, E-32004 Ourense, Spain
- Jiangsu University (CN)
- Corresponding author
- Giampieri, Francesca
- Battino, Maurizio
- ORCID
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2020-07-15
- Volume
- 9
- Issue
- 7
- Pages
- 619
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC7402177
- OpenAlex
- W3042652083
- Cited by
- 217
- References
- 156
- Citations by year
- 2026: 30 · 2025: 32 · 2024: 45 · 2023: 47 · 2022: 29 · 2021: 28 · 2020: 4
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Investigo repository of University of Vigo (University of Vigo) (submittedVersion, other-oa)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, other-oa)
- Investigo Institutional repository of UVigo (Universidade de Vigo) (submittedVersion, cc-by)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
- Keywords
- garlic, organosulfur compounds, polyphenols, nutraceuticals, garlic extract, oxidative stress, inflammation, cancer prevention, cardiovascular disease, metabolic disorders, diabetes mellitus, blood pressure, skin health, bone health, bioavailability, drug interactions, human intervention studies
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